Abstract:
:Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an outpatient basis. Complete control of emetic episodes was achieved in 79% of the courses (n=113/143), major control in 9.1% (n=13/143), minor control in 7.7% (n=11/143) and treatment failure in 4.2% of the courses (n=6/143). Nausea was less well controlled than emetic episodes. 53.1% (n=76/143) of the patients had no nausea, 24.5% (n=35/143) presented with grade 1 nausea, 16.8% (n=24/143) had grade 2, and 5.6% (n=8/143) had grade 3 nausea. The analysis of different groups of chemotherapy regimens according to the most emetogenic substance of a given regimen revealed, that 5-fluorouracil containing regimens were less well controlled then regimens with supposedly higher emetogenic substances. Delayed nausea but not emetic episodes were observed after 16.8% (n=24/143) of the courses indicating that this phenomenon may be a problem not only after cisplatin treatment. Side-effects following ondansetron treatment were obstipation (21%; n=30/143), sedation (11.9%, n=17/143) and headache (9.8%; n=14/143). Other side effects were less frequent and none of the side effects required treatment or discontinuation of the ondansetron administration. Outpatient treatment with ondansetron was effective, safe and well tolerated not ony in the first hemotherapy cycles but also in subsequent cycles.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Casper J,Casper S,Kohnewompner C,Bokemeyer C,Hecker H,Schmoll Hdoi
10.3892/ijo.4.6.1283subject
Has Abstractpub_date
1994-06-01 00:00:00pages
1283-9issue
6eissn
1019-6439issn
1791-2423journal_volume
4pub_type
杂志文章abstract::Ganoderma lucidum (Reishi), an oriental medical mushroom, has been widely used in Asian countries for centuries to prevent or treat different diseases, including cancer. However, the mechanism(s) responsible for the effects of Ganoderma lucidum on cancer cells remain to be elucidated. We have previously demonstrated t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::ETS variant 1 (ETV1) is an oncogenic transcription factor. However, its role in colorectal cancer has remained understudied. The present study demonstrated that ETV1 downregulation led to reduced HCT116 colorectal cancer cell growth and clonogenic activity. Furthermore, the ETV1 mRNA levels were enhanced in colorectal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5133
更新日期:2020-12-01 00:00:00
abstract::The prognostic significance of 20 putative markers has been assessed in a consecutive series of 1,198 patients with malignant lymphoma seen by the Sheffield Lymphoma Group over three decades. Univariate analysis disclosed that ten factors for both Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) Grade I, and tw...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.6.1203
更新日期:2001-12-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000545
更新日期:2010-03-01 00:00:00
abstract::Combination therapy is a promising and prevalent strategy for osteosarcoma treatment. Curcumin (CUR), as a chemosensitizer, improves the antitumor effect of first‑line chemotherapy drugs. However, due to its poor solubility and instability in physiological conditions, the bioavailability of CUR is limited. In order to...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5067
更新日期:2020-08-01 00:00:00
abstract::Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000282
更新日期:2009-06-01 00:00:00
abstract::Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
abstract::Autocrine fibroblast growth factor (FGF) signaling was genetically manipulated in human gliomas by an adenovirus-mediated strategy. Antisense inhibition of endogenous basic FGF (bFGF) expression showed inhibition of the proliferation of human glioma cells (U251MG, NMC-G1) without promoting apoptosis. The reduction in ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::Transforming growth factor beta1 (TGF-beta1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for human breast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, is a well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.16.2.277
更新日期:2000-02-01 00:00:00
abstract::Although it is well established that ras genes contribute to tumourigenesis either through the accumulation of mutations or by aberrant expression in a wide range of human cancers, little is known regarding their involvement in human nasal polyps (NPs). In the present study, the occurrence of mutations in codons 11 an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::The enzyme poly(ADP-ribose)polymerase (PARP) has been implicated in several cellular processes by the demonstration of ADP-ribosylation of proteins which play a role in cellular repair of DNA damage, response to ionizing radiation and apoptosis. In addition, ADP-ribosylation has been shown to play a role in cell cycle...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.4.803
更新日期:1996-04-01 00:00:00
abstract::Benzyl isothiocyanate (BITC) is known for its pharmacological properties against malignant neoplasm, including bladder cancer (BC). The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR‑99a‑5p in BITC‑treated BC cells. A quantitative polymerase chain reaction (...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4763
更新日期:2019-06-01 00:00:00
abstract::The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d‑ or l‑forms of 2‑hydroxyglutarate (2HG) from α‑ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4649
更新日期:2019-02-01 00:00:00
abstract::The relationship between mucin markers and several clinical and pathological characteristics was investigated in breast cancer tissue. CA549, CA15.3 and MCA were measured using commercially available assay methods in 82 primary breast carcinomas and 47 normal glandular breast tissue samples. Similarly to CA15.3 and MC...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.695
更新日期:1993-10-01 00:00:00
abstract::The perineural invasion (PNI) of malignant tumors is a form of tumor progression in which cancer cells encroach along nerves. PNI hinders curative resection. Residual tumor cells in or around nerves can bring about local recurrence, infiltration and metastasis. This behavior is usually associated with a poor clinical ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4311
更新日期:2018-05-01 00:00:00
abstract::RSK2 (90 kDa ribosomal S6 kinase) is a downstream effector of the Ras/ERK (extracellular signal-regulated kinase) signaling pathway that has major functions in cell biological activities, including regulating nuclear signaling, cell cycle progression, cell proliferation, cell growth, protein synthesis, cell migration ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3481
更新日期:2016-06-01 00:00:00
abstract::'Rare sugars' are defined as monosaccharides that exist in nature but are only present in limited quantities. The development of mass production method of rare sugars revealed some interesting physiological effects of these on animal cells, but the mechanisms have not been well studied. We examined the effect of D-all...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::An altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease. Malignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues. In this study, we investigated the expression profiles of 340 mammalian ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1420
更新日期:2012-07-01 00:00:00
abstract::Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2890
更新日期:2015-05-01 00:00:00
abstract::Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1983
更新日期:2013-08-01 00:00:00
abstract::We have previously shown that the genotoxin-induced apoptosis in mouse embryo fibroblasts was enhanced by the extracellular matrix protein fibronectin (FN). In the present study, we tested the hypothesis that FN regulates the DNA damage response (DDR) signaling pathways in HCT116 (p53-wt) and HT29 (p53-mut) human colo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1034
更新日期:2011-08-01 00:00:00
abstract::The expression of microRNA-375 (miR-375) is significantly reduced in cancer tissues of maxillary sinus squamous cell carcinoma (MSSCC). The aim of this study was to investigate the functional significance of miR-375 and a possible regulatory role in the MSSCC networks. Restoration o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1196
更新日期:2012-01-01 00:00:00
abstract::MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.3851
更新日期:2017-03-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is cytotoxic to the majority of cancer cells while sparing most normal cells. However, different prostate carcinoma cell lines respond with different sensitivities to TRAIL, urging us to disclose the mechanisms that determine TRAIL sensitivity in prostate...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-10-01 00:00:00
abstract::The identification of cell surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene expression analysis. The data indicate that there a...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2007-02-01 00:00:00
abstract::The ability of lonidamine (LND), an energolytic derivative of indazol-carboxylic acid, to modulate the cytotoxic activity of idarubicin (IDA) and doxorubicin (DX) was investigated in two human lymphoma cell lines (H9 and U937). A different pattern of interaction between the drugs was observed as a function of treatmen...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.4.675
更新日期:1997-10-01 00:00:00
abstract::We report a retrospective study of all patients with localised non-Hodgkin's lymphoma referred to the Sheffield Lymphoma Group (1970-1995). A total of 1,979 patients with non-Hodgkin's lymphoma were seen: 553 (28%) presented with stage I or II disease, 411 (21%) extranodal, 142 (7%) nodal. The commonest extranodal sit...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.6.1313
更新日期:1998-12-01 00:00:00
abstract::Sodium metaarsenite (NaAs2O3: code name KML001) is an orally bioavailable arsenic compound with potential anti-cancer activity. However, the effect of KML001 has not been studied in acute myeloid leukemia (AML). We investigated the anti-leukemic effect of KML001 in AML, and determined the mode of action of KML001. KML...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2899
更新日期:2015-05-01 00:00:00
abstract::In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. 5-CQA abrogated ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3436
更新日期:2016-05-01 00:00:00