Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer.

abstract：:Ionizing radiation (IR) is frequently unsuccessful in the treatment of cancer because of local failure or distant metastases. The efficacy of systemically administered cytokines for cancer therapy is often limited by toxicity. We report that intratumoral injection of an adenoviral vector with interleukin-12 (IL-12) en...

journal_title：International journal of oncology

authors： Seetharam S,Staba MJ,Schumm LP,Schreiber K,Schreiber H,Kufe DW,Weichselbaum RR

更新日期：1999-10-01 00:00:00

abstract：:This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...

journal_title：International journal of oncology

authors： Van den Neste E,Cardoen S,Offner F,Bontemps F

更新日期：2005-10-01 00:00:00

abstract：:A 60 year old man had two tumours resected from his liver which were shown histologically to be a well differentiated hepatocellular carcinoma and the fibrolamellar variant. Both are considered clinically distinct and of different pathogenesis and have not been previously reported occurring synchronously. DNA analysis...

journal_title：International journal of oncology

authors： Ding S,Wong K,Davidson B,Dooley J,Dhillon A,Wood C,Habib N

更新日期：1992-07-01 00:00:00

abstract：:SOX2, a SRY-related HMG box protein, is thought to be an important transcription factor during organogenesis, including the stomach although the expression and function are unclear. We investigated SOX2 protein expression to clarify its roles in differentiation and carcinogenesis of the stomach. Using polyclonal SOX2 ...

journal_title：International journal of oncology

authors： Li XL,Eishi Y,Bai YQ,Sakai H,Akiyama Y,Tani M,Takizawa T,Koike M,Yuasa Y

更新日期：2004-02-01 00:00:00

abstract：:The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing. The reasons for the failure of the mechanisms of resistance of these inhibitors are unclear, but may involve factors of the tumor microenvironment ...

journal_title：International journal of oncology

authors： Hartel I,Ronellenfitsch M,Wanka C,Wolking S,Steinbach JP,Rieger J

更新日期：2016-07-01 00:00:00

abstract：:Numerous dietary phytochemicals have shown anti-breast carcinogenic activities when tested in vitro; however, in most cases, the demonstrated efficacy of individual phytochemicals requires doses not readily achievable in vivo. Therefore, whether diets might exert translational promises and benefits in clinical setting...

journal_title：International journal of oncology

authors： Hsieh TC,Wu JM

更新日期：2008-10-01 00:00:00

abstract：:The development of resistance to anticancer agents during treatment is a major obstacle in the chemotherapy of cancer. Cells expressing high levels of the P-glycoprotein exhibit a multidrug resistance phenotype. The P-glycoprotein is a membrane phosphoprotein which serves as a drug efflux pump to reduce intracellular ...

journal_title：International journal of oncology

authors： Srivastava R,Srivastava A,Chochung Y

更新日期：1996-11-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, is very closely associated with telomerase activity. Telomerase has been implicated in cellular immortalization and carcinogenesis. In situ detection of hTERT will aid in determining the localization of telomerase-positive cells. The ...

journal_title：International journal of oncology

authors： Kammori M,Izumiyama N,Hashimoto M,Nakamura K,Okano T,Kurabayashi R,Naoki H,Honma N,Ogawa T,Kaminishi M,Takubo K

更新日期：2005-11-01 00:00:00

abstract：:Tetramethypyrazine (TMP), one of the active compounds extracted from the traditional Chinese medicinal herb (Chuanxiong), has been verified as an anticancer compound against several types of cancer. However, understanding of the molecular mechanisms have not been fully elucidated. In the present study, the anticancer ...

journal_title：International journal of oncology

authors： Luan Y,Liu J,Liu X,Xue X,Kong F,Sun C,Wang J,Liu L,Jia H

更新日期：2016-10-01 00:00:00

abstract：:In the present study, a series of seven synthetic croma-kalim analogues were prepared and evaluated for cytotoxic effect on human cervical carcinoma HeLa cells using WST-8 assay. A preliminary screening of these cromakalim analogues showed that 1-[(3S,4R)-4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy- 2,2-dimethylchr...

journal_title：International journal of oncology

authors： Zhang X,Zhao J,Kang S,Yi M,You S,Shin DS,Kim DK

更新日期：2011-12-01 00:00:00

abstract：:The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC a...

journal_title：International journal of oncology

authors： Nowak A,Dziegiel P

更新日期：2018-08-01 00:00:00

abstract：:A camptothecin (CPT) formulation that can be easily administered, is less toxic, and has greater antitumor effect is needed. In this study, a water-soluble CPT derivative was obtained by direct coupling of CPT to poly(L-glutamic acid) (PG) through the C20(S)-hydroxyl group. CPT was released from the resulting conjugat...

journal_title：International journal of oncology

authors： Zou Y,Wu QP,Tansey W,Chow D,Hung MC,Charnsangavej C,Wallace S,Li C

更新日期：2001-02-01 00:00:00

abstract：:Human pancreatic ductal adenocarcinomas overexpress the epidermal growth factor (EGF) receptor. Betacellulin is a mitogenic polypeptide that binds and activates this receptor. To determine whether betacellulin has a role in human pancreatic cancer, we studied its expression in cultured human pancreatic cancer cell lin...

journal_title：International journal of oncology

authors： Yokoyama M,Funatomi H,Kobrin M,Ebert M,Friess H,Buchler M,Korc M

更新日期：1995-10-01 00:00:00

abstract：:On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRR...

journal_title：International journal of oncology

authors： Fujitomo T,Daigo Y,Matsuda K,Ueda K,Nakamura Y

更新日期：2014-07-01 00:00:00

abstract：:Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with liver metastases are candidates for potentially curative surgical resection. The treatment of patients with unresectable liver tumors is a major clinical probl...

journal_title：International journal of oncology

authors： Cai SR,Garbow JR,Culverhouse R,Church RD,Zhang W,Shannon WD,McLeod HL

更新日期：2005-07-01 00:00:00

abstract：:To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...

journal_title：International journal of oncology

authors： Frankfurt O,Seckinger D,Sugarbaker E

更新日期：1994-02-01 00:00:00

abstract：:The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...

journal_title：International journal of oncology

authors： Chen WJ,Xiong ZA,Zhang M,Yao CG,Zhao ZY,Hua YY,Zhou W

更新日期：2013-03-01 00:00:00

abstract：:Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...

journal_title：International journal of oncology

authors： Ahmad SS,Glatzle J,Bajaeifer K,Bühler S,Lehmann T,Königsrainer I,Vollmer JP,Sipos B,Ahmad SS,Northoff H,Königsrainer A,Zieker D

更新日期：2013-08-01 00:00:00

abstract：:The suppressors of cytokine signaling (SOCS) family inhibits not only Janus kinase (JAK)/signal transducers and activators of transcription (STAT) but also focal adhesion kinase (FAK) signaling pathways, and has tumor suppressor activity. Aberrant methylation in the promoter region of the SOCS3 gene frequently occurs ...

journal_title：International journal of oncology

authors： Tokita T,Maesawa C,Kimura T,Kotani K,Takahashi K,Akasaka T,Masuda T

更新日期：2007-03-01 00:00:00

abstract：:In normal human somatic cells, gradual shortening of telomeres may activate the complex cascade of molecular events known as cellular senescence. Experimental evidence from our laboratory suggests that cellular mortality is regulated by two separate mechanisms that we have termed mortality stage 1 (M1) and mortality s...

journal_title：International journal of oncology

authors： Shay J,Wright W,Werbin H

更新日期：1993-10-01 00:00:00

abstract：:Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFkappaB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFkappaB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly in...

journal_title：International journal of oncology

authors： Huang C,Chen N,Ma WY,Dong Z

更新日期：1998-10-01 00:00:00

abstract：:Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...

journal_title：International journal of oncology

authors： Sartippour MR,Heber D,Zhang L,Beatty P,Elashoff D,Elashoff R,Go VL,Brooks MN

更新日期：2002-09-01 00:00:00

abstract：:Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most impor...

journal_title：International journal of oncology

authors： Kawamoto S,Moriwaki K,Nakagawa T,Terao M,Shinzaki S,Yamane-Ohnuki N,Satoh M,Mehta AS,Block TM,Miyoshi E

更新日期：2011-07-01 00:00:00

abstract：:Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

journal_title：International journal of oncology

authors： Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

更新日期：2007-02-01 00:00:00

abstract：:Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...

journal_title：International journal of oncology

authors： Kijima H,Yamazaki H,Nakamura M,Scanlon KJ,Osamura RY,Ueyama Y

更新日期：2004-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found int...

journal_title：International journal of oncology

authors： Allegra A,Alonci A,Campo S,Penna G,Petrungaro A,Gerace D,Musolino C

更新日期：2012-12-01 00:00:00

abstract：:Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic reprogramming to adapt to the tumor microenvironment and survive host defense or therapeutic insults. Intra-tumor heterogeneity and cancer...

journal_title：International journal of oncology

authors： Katoh M

更新日期：2017-11-01 00:00:00

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:Orlistat is an orally administered anti-obesity drug that has shown significant antitumor activity in a variety of tumor cells. To identify the proteins involved in its antitumor activity, we employed a proteomic approach to reveal protein expression changes in the human ovarian can...

journal_title：International journal of oncology

authors： Huang HQ,Tang J,Zhou ST,Yi T,Peng HL,Shen GB,Xie N,Huang K,Yang T,Wu JH,Huang CH,Wei YQ,Zhao X

更新日期：2012-08-01 00:00:00

abstract：:Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...

journal_title：International journal of oncology

authors： Yang JY,Xia W,Hu MC

更新日期：2006-09-01 00:00:00