Differences in the tumor DNA analysis of a hepatocellular-carcinoma and a synchronous fibrolamellar variant.

abstract：:After the publication of the article, the authors have realized that the affiliation presented for the joint co‑author listed on the paper (Jian‑Ren Tu) was incorrect. The correct author list (and affiliations) should therefore have been published as follows: Yu‑Hua Xu1*, Jian‑Ren Tu2*, Tian‑Tian Zhao3, Shi‑Guang Xie3...

journal_title：International journal of oncology

authors： Xu YH,Tu JR,Zhao TT,Xie SG,Tang SB

更新日期：2019-07-01 00:00:00

abstract：:The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstrated that recombinant REIC/Dkk-3 protein induced the differentiation of h...

journal_title：International journal of oncology

authors： Watanabe M,Kashiwakura Y,Huang P,Ochiai K,Futami J,Li SA,Takaoka M,Nasu Y,Sakaguchi M,Huh NH,Kumon H

更新日期：2009-03-01 00:00:00

abstract：:Dose is a critical determinant of the efficacy of chemotherapy. The dose response curve for virtually all anticancer agents is steep in both in vitro and in vivo experimental studies. However the application of the steep dose-response curve in the clinic has been troublesome for many years because of dose limiting bon...

journal_title：International journal of oncology

authors： Honkoop A,Pinedo H

更新日期：1995-04-01 00:00:00

abstract：:Highly aggressive murine B16 melanoma was engineered to secrete IFN-alpha constitutively. Cells expressing IFN-alpha were injected into syngeneic C57BL/6 mice and the mice were monitored for tumor development. Secretion of IFN-alpha by B16 melanoma cells completely abrogated their tumorigenicity in syngeneic mice. LFN...

journal_title：International journal of oncology

authors： Sarkar S,Flores I,Ron Y,Derosa C,Ozzello L,Pestka S

更新日期：1995-07-01 00:00:00

abstract：:The support mechanisms that are involved in lymph-node metastasis of oral squamous cell carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. In this study, we examined...

journal_title：International journal of oncology

authors： Ishikawa T,Nakashiro K,Hara S,Klosek SK,Li C,Shintani S,Hamakawa H

更新日期：2006-01-01 00:00:00

abstract：:A major limitation of cancer chemotherapy is development of resistance. In this study, we analyzed KB-3-1 cells and adriamycin-selected multidrug resistant sublines KB-A1 and KB-A10 cells for mechanisms of resistance. KB-A10 cells are 10-fold more resistant than KB-A1 cells but have lower P-glycoprotein. Of the known ...

journal_title：International journal of oncology

authors： Villagra L,Darling A,Yassa D,Scheper R,Tritton T,Bhushan A

更新日期：1997-11-01 00:00:00

abstract：:The purpose of this study was to determine, using fluorescence in situ hybridization (FISH), whether treatment of cancer cells with 3'-azido-2'-3'-dideoxythymidine (AZT) has any effect on telomere length as determined by the telomeric signal intensity. To do so, we treated a metastatic murine melanoma cell line (K-173...

journal_title：International journal of oncology

authors： Multani AS,Furlong C,Pathak S

更新日期：1998-11-01 00:00:00

abstract：:Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/...

journal_title：International journal of oncology

authors： Mizutani Y,Katsuoka Y,Bonavida B

更新日期：2012-04-01 00:00:00

abstract：:We have carried out three rounds of screening tests using 239 synthetic tripeptides for the growth-inhibitory activity toward tumor cells and found that those having amino acid sequences of Pro-Thr-Trp or Glu-Arg-Pro effectively inhibit proliferation of transformed cells. These peptides could be the fundamental struct...

journal_title：International journal of oncology

authors： Hiwasa T,Soeda C,Takanohashi S,Kobayashi H,Suzuki A,Ueyama T,Ike Y

更新日期：1996-01-01 00:00:00

abstract：:Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymi...

journal_title：International journal of oncology

authors： Nishioka K,Fujimori Y,Hashimoto-Tamaoki T,Kai S,Qiu H,Kobayashi N,Tanaka N,Westerman KA,Leboulch P,Hara H

更新日期：2003-10-01 00:00:00

abstract：:CD34 is commonly used as an endothelial cell marker of tumor vessels. However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed endothelial cells. In this study,...

journal_title：International journal of oncology

authors： Teranishi N,Naito Z,Ishiwata T,Tanaka N,Furukawa K,Seya T,Shinji S,Tajiri T

更新日期：2007-03-01 00:00:00

abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

journal_title：International journal of oncology

authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

更新日期：1993-04-01 00:00:00

abstract：:Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. ...

journal_title：International journal of oncology

authors： Kubo T,Sugita T,Shimose S,Nitta Y,Ikuta Y,Murakami T

更新日期：2000-08-01 00:00:00

abstract：:Oncogenic, moderately immunogenic MK16/1/IIIABC (MK16) cells were previously established by co-transfection of HPV 16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of the MK16 cells produced progressively growing neoplasms which metastasized spontaneously to lungs. In t...

journal_title：International journal of oncology

authors： Mendoza L,Bubeník J,Símová J,Jandlová T,Vonka V,Mikysková R

更新日期：2003-07-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:We examined the effects of suppressing multidrug resistance-associated protein (MRP) and multidrug resistance 1 (MDR1) gene expression in HCT-8DDP human colon cancer cell lines, which showed both cisplatin and multidrug resistance. Hammerhead ribozymes, designed to cleave MRP mRNA (anti-MRP Rz) and MDR1 mRNA (anti-MDR...

journal_title：International journal of oncology

authors： Nagata J,Kijima H,Hatanaka H,Asai S,Miyachi H,Abe Y,Yamazaki H,Nakamura M,Watanabe N,Mine T,Kondo T,Scanlon KJ,Ueyama Y

更新日期：2002-11-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted therapies due to lack of related receptors. These patients overexpress the epidermal growth factor receptor (EGFR), but are resistant to tyrosine kinase inhibitors (TKIs) and anti-EGFR therapies. Mechanisms suggested for...

journal_title：International journal of oncology

authors： Bellizzi A,Greco MR,Rubino R,Paradiso A,Forciniti S,Zeeberg K,Cardone RA,Reshkin SJ

更新日期：2015-03-01 00:00:00

abstract：:Endoscopic examination with iodine staining has led to the easy detection of multiple superficial esophageal carcinoma (MSEC). The purpose of this study was to better understand the characteristics of MSEC. Of 49 patients with multiple esophageal carcinomas, 19 had superficial carcinoma. Multiple esophageal carcinomas...

journal_title：International journal of oncology

authors： Fujii T,Yamana H,Fujita H,Sueyoshi S,Nakashima A,Hayashi I,Nishi M,Kato S,Shirouzu K,Morimatsu M

更新日期：1998-02-01 00:00:00

abstract：:The prognostic significance of Ki 67/MIB1 immunohistochemical assays (ICAs) was investigated in optimal technical conditions in 139 breast carcinomas. Automated ICAs (immunoperoxidase/Ventana device) was performed on frozen sections. Immunoprecipitates were quantified by computerized analysis (SAMBA) of digitized micr...

journal_title：International journal of oncology

authors： Charpin C,Garcia S,Bouvier C,Devictor B,Andra L,Lavaut M,Allasia C,Bonnier P

更新日期：1996-08-01 00:00:00

abstract：:Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon alpha (IFN-alpha) as a single agent or combined with standard chemo-therapy has been shown to inhibit various tumors, but the effect of combination anti-angiog...

journal_title：International journal of oncology

authors： Son MJ,Song HS,Kim MH,Kim JT,Kang CM,Jeon JW,Park SY,Kim YJ,Groves MD,Park K,Kim JH,Nam DH

更新日期：2006-06-01 00:00:00

abstract：:One of the genes that the authors have isolated by a differential display of hepatocellular carcinoma compared to adjacent liver is the alpha6 integrin. alpha6 integrin is the major adhesion receptor for laminin and is suggested to be involved in tumor cell invasion and metastasis. To our knowledge, however, there are...

journal_title：International journal of oncology

authors： Tanaka Y,Mimori K,Shiraishi T,Ohkura Y,Takubo K,Mafune K,Barnard GF,Mori M

更新日期：2000-04-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:Metal-containing compounds have been extensively studied for many years as potent proteasome inhibitors. The 20S proteasome, the main component of the ubiquitin proteasome pathway, is one of the excellent targets in anticancer drug development. We recently reported that several copper complexes were able to inhibit ca...

journal_title：International journal of oncology

authors： Zhang Z,Wang H,Wang Q,Yan M,Wang H,Bi C,Sun S,Fan Y

更新日期：2016-08-01 00:00:00

abstract：:The relation between the consumption of cruciferous vegetables and reduced prostate cancer occurrence has been documented, although the responsible phytochemicals are unknown. The effects of sulforaphane (SFN) which occurs as the precursor glucosinolate in broccoli and other cruciferous vegetables, and its metabolite ...

journal_title：International journal of oncology

authors： Chiao JW,Chung FL,Kancherla R,Ahmed T,Mittelman A,Conaway CC

更新日期：2002-03-01 00:00:00

abstract：:Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...

journal_title：International journal of oncology

authors： Kondo R,Ishino K,Wada R,Takata H,Peng WX,Kudo M,Kure S,Kaneya Y,Taniai N,Yoshida H,Naito Z

更新日期：2019-04-01 00:00:00

abstract：:Obesity is considered a risk factor for many cancers, including breast cancer. Our laboratory has previously shown that leptin is mitogenic in many cancer cell lines, including breast. Information regarding the effects of high leptin levels on leptin receptor expression and signaling is lacking. The purpose of this st...

journal_title：International journal of oncology

authors： Frankenberry KA,Skinner H,Somasundar P,McFadden DW,Vona-Davis LC

更新日期：2006-04-01 00:00:00

abstract：:Sialic acid-containing glycosphingolipids, gangliosides, are expressed at high levels in the nerve tissues and various tumor cells. Although a number of studies on the roles of gangliosides in the regulation of cell proliferation have been performed, the mechanisms for the regulation are not well understood. We establ...

journal_title：International journal of oncology

authors： Nishio M,Tajima O,Furukawa K,Urano T,Furukawa K

更新日期：2005-01-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00