Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:Thymidine kinase (TK) activity in rat hepatoma JB1 and AH136B was mainly due to cytosolic TK and was much higher than that in rat regenerating liver. Two forms of cytosolic TK, designated as TK-I and TK-II, were revealed in addition to mitochondrial TK in anion-exchange high performance liquid chromatography (HPLC) of...

journal_title：International journal of oncology

authors： Lin L,Islam MM,Du M,Ohmura Y,Hiwasa T,Fujimura S

更新日期：1999-08-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. However, the effects of SAL on metastatic capacity of HT1080 human fibrosarcoma cells have not been elucidated. We investigated the effect of SAL on migration an...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2016-06-01 00:00:00

abstract：:Although the incidence of brain metastasis in gastric cancer is relatively low, its prevalence may increase with improved therapy and longer survival tumors. The molecular mechanisms underlying brain metastases are not well understood. To gain insight into the mechanism of brain metastasis, we studied differences in m...

journal_title：International journal of oncology

authors： Minn YK,Lee DH,Hyung WJ,Kim JE,Choi J,Yang SH,Song H,Lim BJ,Kim SH

更新日期：2014-12-01 00:00:00

abstract：:The objective of this study was to assess the toxicity and immunological response induced by autologous dendritic cells (DCs) pulsed with allogeneic tumor lysate in a pancreatic cancer patient. The lack of available tumor peptides in pancreatic cancer strongly supports the idea to use allogeneic tumor cells as a sourc...

journal_title：International journal of oncology

authors： Stift A,Friedl J,Dubsky P,Bachleitner-Hofmann T,Benkoe T,Brostjan C,Jakesz R,Gnant M

更新日期：2003-03-01 00:00:00

abstract：:The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...

journal_title：International journal of oncology

authors： Goh HS,Elnatan J,Low CH,Smith DR

更新日期：1999-09-01 00:00:00

abstract：:Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...

journal_title：International journal of oncology

authors： Shaughnessy M,Lamuraglia G,Klebanov N,Ji Z,Rajadurai A,Kumar R,Flaherty K,Tsao H

更新日期：2019-11-01 00:00:00

abstract：:CDH13 (H-cadherin) is a member of the cadherin superfamily, which plays an important role in cell recognition and adhesion. We examined the expression and methylation status of the CDH13 gene in diffuse large B cell lymphomas (B-DLCLs). We found decreased expression of the CDH13 gene in all of 6 hematopoietic cell lin...

journal_title：International journal of oncology

authors： Ogama Y,Ouchida M,Yoshino T,Ito S,Takimoto H,Shiote Y,Ishimaru F,Harada M,Tanimoto M,Shimizu K

更新日期：2004-09-01 00:00:00

abstract：:To evaluate the distribution of cyclin protein expression, in relation to cell proliferation rate and clinical behavior, an immunohistochemical study was performed on 92 tumor samples of patients with high grade osteosarcoma (OS). A large cyclin A- and cyclin E-positive fraction was found respectively in 59% and 47% o...

journal_title：International journal of oncology

authors： Molendini L,Benassi MS,Magagnoli G,Merli M,Sollazzo MR,Ragazzini P,Gamberi G,Ferrari C,Balladelli A,Bacchini P,Picci P

更新日期：1998-05-01 00:00:00

abstract：:The hematogenous metastasis of cancer consists of a multistep process. It is surmised that a number of interactions between cancer and endothelial cells occur, with cell adhesion molecules playing certain roles in this process. The authors conducted an investigation on the interaction between human cancer cells and cu...

journal_title：International journal of oncology

authors： Sato M,Narita T,Kimura N,Nakashio T,Hashimoto T,Manabe T,Kannagi R

更新日期：1997-06-01 00:00:00

abstract：:Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon alpha (IFN-alpha) as a single agent or combined with standard chemo-therapy has been shown to inhibit various tumors, but the effect of combination anti-angiog...

journal_title：International journal of oncology

authors： Son MJ,Song HS,Kim MH,Kim JT,Kang CM,Jeon JW,Park SY,Kim YJ,Groves MD,Park K,Kim JH,Nam DH

更新日期：2006-06-01 00:00:00

abstract：:Thymidylate synthase (TS) is an essential enzyme for DNA biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-FU), which is frequently used against human colon adenocarcinomas. Because levels of TS in such tumors may be predictive of chemotherapeutic response to 5-FU...

journal_title：International journal of oncology

authors： Weitz S,Wildrick D,Boman B

更新日期：1993-02-01 00:00:00

abstract：:The relationship between mucin markers and several clinical and pathological characteristics was investigated in breast cancer tissue. CA549, CA15.3 and MCA were measured using commercially available assay methods in 82 primary breast carcinomas and 47 normal glandular breast tissue samples. Similarly to CA15.3 and MC...

journal_title：International journal of oncology

authors： Gion M,Plebani M,Mione R,Capitanio G,Penzo C,Meo S

更新日期：1993-10-01 00:00:00

abstract：:We included in a case-control study on brain tumours and mobile and cordless telephones 1,617 patients aged 20-80 years of both sexes diagnosed during January 1, 1997 to June 30, 2000. They were alive at the study time and had histopathology verified brain tumour. One matched control to each case was selected from the...

journal_title：International journal of oncology

authors： Hardell L,Mild KH,Carlberg M

更新日期：2003-02-01 00:00:00

abstract：:On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRR...

journal_title：International journal of oncology

authors： Fujitomo T,Daigo Y,Matsuda K,Ueda K,Nakamura Y

更新日期：2014-07-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumo...

journal_title：International journal of oncology

authors： Jögi A,Abel F,Sjöberg RM,Toftgård R,Zaphiropoulos PG,Påhlman S,Martinsson T,Axelson H

更新日期：2000-05-01 00:00:00

abstract：:Extrahepatic cholangiocarcinoma (CC) is an aggressive malignancy with dismal prognosis and characterized by early invasion, metastasis and postoperative recurrence. Therefore, understanding the main molecular mechanisms of this malignancy is the key for the development of novel and effective therapeutic strategies for...

journal_title：International journal of oncology

authors： Qiang Y,Wang F,Yan S,Zhang H,Zhu L,Chen Z,Tu F,Wang D,Wang G,Wang W,Chen Z

更新日期：2015-01-01 00:00:00

abstract：:Medulloblastoma is the most common malignant brain tumor in childhood. The most prevalent chromosomal abnormalities are isochromosome 17q and loss of 17p, the location of the tumor suppressor gene p53. Mutations in the p53 gene in medulloblastoma are relatively infrequent but have recently been correlated to poor prog...

journal_title：International journal of oncology

authors： Philipova T,Baryawno N,Hartmann W,Pietsch T,Druid H,Johnsen JI,Ekström TJ

更新日期：2011-03-01 00:00:00

abstract：:Previously, we found that the injection of zoledronic acid (ZOL) into mice bearing tumor induced changes of the vascular structure in the tumor. In this study, we examined whether ZOL treatment could decrease interstitial fluid pressure (IFP) via change of tumor vasculature, and enhance the antitumor efficacy of lipos...

journal_title：International journal of oncology

authors： Hattori Y,Shibuya K,Kojima K,Miatmoko A,Kawano K,Ozaki K,Yonemochi E

更新日期：2015-07-01 00:00:00

abstract：:A431 resistant variants to epoxomicin (EXM) were established, showing 4.0-6.7 times more resistance to EXM than parental A431P. Both variants demonstrated increased expression of the beta-subunit molecules of 26S proteasome with approximately 2.5 times increased activity. In variant cells, cyclin B and P34cdc2 were ov...

journal_title：International journal of oncology

authors： Ohkawa K,Asakura T,Aoki K,Shibata S,Minami J,Fujiwara C,Sai T,Marushima H,Kuzuu H

更新日期：2004-02-01 00:00:00

abstract：:Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. F...

journal_title：International journal of oncology

authors： Takeda K,Tomimori K,Kimura R,Ishikawa C,Nowling TK,Mori N

更新日期：2012-01-01 00:00:00

abstract：:We assessed Stanniocalcin-1 (STC-1) mRNA expression in human normal tissues, various types of human cancer cell lines, and cancer tissues obtained during surgery. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay developed to detect STC-1 mRNA, the transcripts were detected in 20 out of 21 cancer ...

journal_title：International journal of oncology

authors： Fujiwara Y,Sugita Y,Nakamori S,Miyamoto A,Shiozaki K,Nagano H,Sakon M,Monden M

更新日期：2000-04-01 00:00:00

abstract：:The inhibitor of oxidative phosphorylation, 2,4-dinitrophenol (DNP), abrogates etoposide cytotoxicity in murine leukemia L1210 cells without affecting the quantity of drug-induced DNA lesions. Cell cycle arrest and events associated with cell death were followed in etoposide treated L1210 cells under conditions in whi...

journal_title：International journal of oncology

authors： Lock R,Thompson B,Stribinskiene L

更新日期：1996-02-01 00:00:00

abstract：:Meningiomas are the most commonly occurring tumors of the central nervous system including the brain and spinal cord. Malignant meningiomas are highly aggressive and frequently recur after surgical resection of the tumor. Our previous studies have reported that urokinase plasminogen activator receptor (uPAR) and matri...

journal_title：International journal of oncology

authors： Tummalapalli P,Gondi CS,Dinh DH,Gujrati M,Rao JS

更新日期：2007-07-01 00:00:00

abstract：:Optimal conditions have been defined to grow primary cultures of malignant melanoma suitable for in vitro pharmacological studies. A feasibility of primary cultures was observed in 60% of 62 clinical melanoma lymph node metastases. The neoplastic nature of the cells grown in culture, as assessed by the highly specific...

journal_title：International journal of oncology

authors： Villa R,Zaffaroni N,Orlandi L,Costa A,Veronese S,Vaglini M,Silvestrini R

更新日期：1992-11-01 00:00:00

abstract：:To investigate the usefulness of oral doxifluridine (5'-DFUR), an active intermediate metabolite of capecitabine (XELODA), in gastric cancer patients after curative resection, we conducted a phase III randomized controlled study to compare oral 5'-DFUR and oral 5-fluorouracil (5-FU). 485 gastric cancer patients with S...

journal_title：International journal of oncology

authors： Takiguchi N,Nakajima N,Saitoh N,Fujimoto S,Nakazato H

更新日期：2000-05-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:Many clinical studies highlight the dichotomous role of PRDXs in human cancers, where they can exhibit strong tumor-suppressive or tumor-promoting functions. Recent evidence suggests that lower expression of PRDXs correlates with cancer progression in colorectal cancer (CRC) or in esophageal squamous carcinoma. In the...

journal_title：International journal of oncology

authors： Nicolussi A,D'Inzeo S,Mincione G,Buffone A,Di Marcantonio MC,Cotellese R,Cichella A,Capalbo C,Di Gioia C,Nardi F,Giannini G,Coppa A

更新日期：2014-02-01 00:00:00

abstract：:The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...

journal_title：International journal of oncology

authors： Wang Q,Hao J,Pu J,Zhao L,Lü Z,Hu J,Yu Q,Wang Y,Xie Y,Li G

更新日期：2011-10-01 00:00:00