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A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.

Abstract：

:To investigate the usefulness of oral doxifluridine (5'-DFUR), an active intermediate metabolite of capecitabine (XELODA), in gastric cancer patients after curative resection, we conducted a phase III randomized controlled study to compare oral 5'-DFUR and oral 5-fluorouracil (5-FU). 485 gastric cancer patients with Stage II or III operative findings at curative resection were registered and administered 5'-DFUR (460 mg/m2/day, daily, for two years) or 5-FU (115 mg/m2/day, daily, for the same period). Although no differences in overall survival or disease-free survival were detected, subset analysis showed 5'-DFUR was more effective in reducing peritoneal recurrence than 5-FU (p = 0.047), and in patients with Stage III or stage IIIb (histologic findings) in the 5'-DFUR group had more favorable disease-free survival curves and survival curves than the 5-FU group with similar stages.

journal_name

Int J Oncol

journal_title

International journal of oncology

authors

Takiguchi N,Nakajima N,Saitoh N,Fujimoto S,Nakazato H

doi

10.3892/ijo.16.5.1021

keywords:

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

1021-7

issue

5

eissn

1019-6439

issn

1791-2423

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验

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