Differential forms of p53 in medulloblastoma primary tumors, cell lines and xenografts.

abstract：:It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...

journal_title：International journal of oncology

authors： Katiyar SK

更新日期：2002-12-01 00:00:00

abstract：:Hepatitis B virus (HBV)‑related hepatocellular carcinoma (HCC) is a global health problem that accounts for more than half of total liver cancer cases in developing countries. Despite the growing number of researches conducted, the molecular mechanism underlying the development of HCC remains elusive. Long non‑coding ...

journal_title：International journal of oncology

authors： Zhang H,Chen X,Zhang J,Wang X,Chen H,Liu L,Liu S

更新日期：2020-01-01 00:00:00

abstract：:MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...

journal_title：International journal of oncology

authors： Kim EA,Kim TG,Sung EG,Song IH,Kim JY,Doh KO,Lee TJ

更新日期：2017-03-01 00:00:00

abstract：:The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...

journal_title：International journal of oncology

authors： Ebert M,Yokoyama M,Kobrin M,Friess H,Buchler M,Korc M

更新日期：1994-12-01 00:00:00

abstract：:The proteins of the rho gene family have been isolated from cytosolic as well as particulate fractions. The rho proteins have values of about 22KDa and have consensus amino acid sequences for GTP/GDP-binding and GTPase activities. We have localized the rho proteins in mammalian cells by using affinity-purified anti-pe...

journal_title：International journal of oncology

authors： Hauser C,Avraham S,Avraham H

更新日期：1993-12-01 00:00:00

abstract：:We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two other non-small cell lung cancer (NSCLC) cell lines: NCI-H1299 and A549 cells (IC50 values = 7.6 and 16.1 nM, respectively). Our experiments further showed tha...

journal_title：International journal of oncology

authors： Choi JY,Hong WG,Cho JH,Kim EM,Kim J,Jung CH,Hwang SG,Um HD,Park JK

更新日期：2015-10-01 00:00:00

abstract：:The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...

journal_title：International journal of oncology

authors： Wang Q,Hao J,Pu J,Zhao L,Lü Z,Hu J,Yu Q,Wang Y,Xie Y,Li G

更新日期：2011-10-01 00:00:00

abstract：:PDZ-domain protein GIPC1/GIPC interacts with GTPase-activating protein RGS-GAIP, TGFbeta type III receptor, and integrin alpha6A subunit. Kermit, a Xenopus orthologue of human GIPC1, interacts with some class of WNT receptor. In this study, we identified a novel GIPC1-related gene in human genome by using bioinformati...

journal_title：International journal of oncology

authors： Kirikoshi H,Katoh M

更新日期：2002-03-01 00:00:00

abstract：:The aim of this study was to assess pivotal factors determining the oxygenation status of malignant tumors, and, for comparison, of normal tissues. For this purpose, microvascular patterns, blood flow data, O2 consumption rates and O2 extractions were correlated to the median pO2 values of isografted rodent and xenogr...

journal_title：International journal of oncology

authors： Vaupel P,Thews O,Kelleher DK,Konerding MA

更新日期：2003-04-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerob...

journal_title：International journal of oncology

authors： Xu H,Zeng Y,Liu L,Gao Q,Jin S,Lan Q,Lai W,Luo X,Wu H,Huang Y,Chu Z

更新日期：2017-10-01 00:00:00

abstract：:Sentinel node (SN) mapping and biopsy is a procedure that accurately stages the regional lymph node (LN) basin. Defined patterns of lymphatic drainage allow intraoperative determination of the first (sentinel) lymph node in the regional basin, and the absence of metastatic disease in the SN accurately reflects the abs...

journal_title：International journal of oncology

authors： Gennari R,Stoldt HS,Bartolomei M,Zurrida S,Testori A,Mazzarol G,Paganelli G,Veronesi U

更新日期：1999-07-01 00:00:00

abstract：:Tetramethypyrazine (TMP), one of the active compounds extracted from the traditional Chinese medicinal herb (Chuanxiong), has been verified as an anticancer compound against several types of cancer. However, understanding of the molecular mechanisms have not been fully elucidated. In the present study, the anticancer ...

journal_title：International journal of oncology

authors： Luan Y,Liu J,Liu X,Xue X,Kong F,Sun C,Wang J,Liu L,Jia H

更新日期：2016-10-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:Overexpression of HIF-1α, a transcription factor responsive to hypoxia, is frequently observed in malignant tumors, which sometimes show resistance to chemotherapy and radiation therapy. Consequently, decrease of HIF-1α through virotherapy offers a logical strategy for the treatment of aggressive tumors. In this study...

journal_title：International journal of oncology

authors： Cho IR,Kaowinn S,Moon J,Soh J,Kang HY,Jung CR,Oh S,Song H,Koh SS,Chung YH

更新日期：2015-05-01 00:00:00

abstract：:The p53-induced wig-1 gene encodes an unusual nuclear zinc finger protein with high sequence similarity between human, rat and mouse. Wig-1 belongs to a group of proteins with widely spaced zinc fingers that bind double stranded (ds) RNA. We show here that wig-1 is present in Gallus gallus (chicken), Silurana tropical...

journal_title：International journal of oncology

authors： Hellborg F,Wiman KG

更新日期：2004-06-01 00:00:00

abstract：:Seaweeds are commonly used as functional foods and drugs. A glycoprotein (GP) from the green alga Capsosiphon fulvescens (Cf) has been reported to have antitumor activity toward various cancer cells. We previously observed that Cf-GP induced different pathways of apoptosis in AGS human gastric cancer cells. Transformi...

journal_title：International journal of oncology

authors： Kim YM,Kim IH,Nam TJ

更新日期：2013-10-01 00:00:00

abstract：:Neuroblastoma shows complex patterns of genetic aberrations including MYCN amplification, deletion of chromosome 1p or 11q, and gain of chromosome 17q. The 17q gain is frequently observed in high-risk neuroblastomas, however, the candidate genes still remain elusive. In the present study, we integrated the data of com...

journal_title：International journal of oncology

authors： Yu M,Ohira M,Li Y,Niizuma H,Oo ML,Zhu Y,Ozaki T,Isogai E,Nakamura Y,Koda T,Oba S,Yu B,Nakagawara A

更新日期：2009-04-01 00:00:00

abstract：:Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG i...

journal_title：International journal of oncology

authors： Park JS,Khoi PN,Joo YE,Lee YH,Lang SA,Stoeltzing O,Jung YD

更新日期：2013-03-01 00:00:00

abstract：:Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide that selectively induces apoptosis in several different types of human cancer cells. However, the potential use of LfcinB as an anticancer agent is presently limited by the need for relatively high concentrations of the peptide to trigger apoptosis. Cer...

journal_title：International journal of oncology

authors： Furlong SJ,Ridgway ND,Hoskin DW

更新日期：2008-03-01 00:00:00

abstract：:We have examined six patients with multiple low grade, low stage superficial multifocal bladder tumors with surrounding tissues for loss of heterozygosity (LOH) and microsatellite instability at chromosome 3, totaling 76 samples. The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FH...

journal_title：International journal of oncology

authors： Louhelainen J,Wijkström H,Hemminki K

更新日期：2001-01-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of p53. Increasing evidence shows that miR-34a dysregulation may contribute to tumor development and progression in numerous cancers, includ...

journal_title：International journal of oncology

authors： Yang L,Song X,Zhu J,Li M,Ji Y,Wu F,Chen Y,Cui X,Hu J,Wang L,Cao Y,Wei Y,Zhang W,Li F

更新日期：2017-07-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation. In addition, it has been observe...

journal_title：International journal of oncology

authors： Cao Q,Ruan H,Wang K,Song Z,Bao L,Xu T,Xiao H,Wang C,Cheng G,Tong J,Meng X,Liu D,Yang H,Chen K,Zhang X

更新日期：2018-07-01 00:00:00

abstract：:The in situ formation of cytotoxic metabolites by an enzyme-catalyzed reaction is a recent approach in cancer therapy. The present results show that multidrug-resistant human colon adenocarcinoma cells (LoVo) are significantly more sensitive than corresponding wild-type cells to hydrogen peroxide and aldehydes, the pr...

journal_title：International journal of oncology

authors： Agostinelli E,Vedova LD,Belli F,Condello M,Arancia G,Seiler N

更新日期：2006-10-01 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra-cranial solid tumor in children and despite aggressive therapy survival rates remain low. One of the contributing factors for low survival rates is aggressive tumor angiogenesis, which is known to increase due to radiation, one of the standard therapies for neuroblastoma. Th...

journal_title：International journal of oncology

authors： Boyineni J,Tanpure S,Gnanamony M,Antony R,Fernández KS,Lin J,Pinson D,Gondi CS

更新日期：2016-10-01 00:00:00

abstract：:Cancer stem cells (CSCs) are known to influence chemoresistance, survival, relapse and metastasis. Aldehyde dehydrogenase (ALDH) functions as an epithelial CSC marker. In the present study, we investigated the involvement of ALDH in gastric CSC maintenance, chemoresistance and survival. Following screening for eight c...

journal_title：International journal of oncology

authors： Nishikawa S,Konno M,Hamabe A,Hasegawa S,Kano Y,Ohta K,Fukusumi T,Sakai D,Kudo T,Haraguchi N,Satoh T,Takiguchi S,Mori M,Doki Y,Ishii H

更新日期：2013-04-01 00:00:00

abstract：:Although peritoneal lavage with distilled water performed after surgery prevents peritoneal seeding, cancer cells may avoid rupture under mild hypotonicity through regulatory volume decrease (RVD), which is the homeostatic regulation of ion and water transport. The aim of the present study was to investigate the effec...

journal_title：International journal of oncology

authors： Shiozaki A,Yamazato Y,Kosuga T,Kudou M,Shoda K,Arita T,Konishi H,Komatsu S,Kubota T,Fujiwara H,Okamoto K,Marunaka Y,Otsuji E

更新日期：2019-10-01 00:00:00

abstract：:We examined the gene expression profiles of esophageal squamous cell carcinomas (ESCCs) with respect to degree of invasive depth and lymph node (LN) involvement in a large cohort. We used high-density oligonucleotide microarrays to examine the expression of 22,115 genes in 54 ESCCs and 11 non-cancerous esophageal tiss...

journal_title：International journal of oncology

authors： Sato T,Iizuka N,Hamamoto Y,Yoshino S,Abe T,Takeda S,Uchimura S,Miyamoto T,Sei F,Hamada K,Yamada-Okabe H,Oka M

更新日期：2006-05-01 00:00:00

abstract：:Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...

journal_title：International journal of oncology

authors： Nozaki Y,Isobe K,Nakashima I,Shimokata K

更新日期：1993-06-01 00:00:00