Abstract:
:The proteins of the rho gene family have been isolated from cytosolic as well as particulate fractions. The rho proteins have values of about 22KDa and have consensus amino acid sequences for GTP/GDP-binding and GTPase activities. We have localized the rho proteins in mammalian cells by using affinity-purified anti-peptide antibodies in immunofluorescence and immunoelectron microscopy studies. The majority of rho appears to be concentrated in the mitochondrial membranes while a small fraction is seen in the cytoplasm and in the cytosolic lysosomal compartments, suggesting that rho protein(s) might be involved in the mitochondrial function or assembly.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Hauser C,Avraham S,Avraham Hdoi
10.3892/ijo.3.6.1103subject
Has Abstractpub_date
1993-12-01 00:00:00pages
1103-10issue
6eissn
1019-6439issn
1791-2423journal_volume
3pub_type
杂志文章abstract::The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers. However, the function and molecular mechanisms of CXCR7 in human colorectal cancer (CRC) are still undefined. In the present study, sixty-eight cases of CRC tissues and corresponding adjac...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2547
更新日期:2014-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Retroviral reverse transcriptase (RT) plays a definite role in retroviral life cycle and is essential for the process of retrotransposition. We investigated the RNA expression of endogenous reverse transcriptases (enRTs) in the NIH3T3 mouse genome using, as a probe, a mixture of RT-PCR generated reverse transcriptase ...
journal_title:International journal of oncology
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abstract::It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...
journal_title:International journal of oncology
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abstract::The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...
journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Ganoderma lucidum (Curt.:Fr.) P. Karst, a medicinal fungus, has been widely used in Asian countries for centuries to prevent or treat a variety of diseases, including cancer. However, the mechanisms responsible for the effects of G. lucidum on cancer cells remain to be elucidated. We have previously shown that ethyl a...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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abstract::Pancreatic cancer (PanC) is one of the most lethal malignancies, and resistance towards gemcitabine, the front-line chemotherapy, is the main cause for dismal rate of survival in PanC patients; overcoming this resistance remains a major challenge to treat this deadly malignancy. Whereas several molecular mechanisms ar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2885
更新日期:2015-04-01 00:00:00
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更新日期:1995-07-01 00:00:00
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abstract::MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2596
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abstract::Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide that selectively induces apoptosis in several different types of human cancer cells. However, the potential use of LfcinB as an anticancer agent is presently limited by the need for relatively high concentrations of the peptide to trigger apoptosis. Cer...
journal_title:International journal of oncology
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doi:
更新日期:2008-03-01 00:00:00
abstract::Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...
journal_title:International journal of oncology
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doi:10.3892/ijo.2016.3606
更新日期:2016-09-01 00:00:00
abstract::Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against brea...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2302
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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abstract::MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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