Abstract:
:Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against breast cancer cells. In particular, we have become interested in the ethanolic extract from Senecio graveolens (synonym of S. nutans), a plant commonly called Chachacoma, in an effort to isolate compounds that could demonstrate cytotoxic effects on breast cancer cells. Senecio (Asteraceae) is the largest gender in Chile comprising approximatly 200 species. These herbs inhabit areas over 3,500 meters above the sea level in the Andes Mountains. S. graveolens is commonly used by local communities for its medicinal properties, particularly its capacity to ameliorate high-altitude-associated sickness. The cytotoxic effect of the alcoholic extract from S. graveolens, as well as its most abundant compound 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone, were tested in the breast cancer cell lines ZR-75-1, MCF-7 and MDA-MB‑231, and non-tumorigenic MCF-10F cells. We show that the phytochemical extract was able to induce cytotoxicity in cancer cells but not in MCF-10F. Importantly, this effect was enhanced under hypoxic conditions. However, 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone, the main compound, did not by itself show an effective anticarcinogenic activity in comparison to the whole extract. Interestingly, the cytotoxic effect of the phytochemical extract was dependent on the basal MnSOD protein expression. Thus, cytotoxicity was increased when MnSOD levels were low, but resistance was evident when protein levels were high. Additionally, the crude extract seems to trigger cell death by a variety of processes, including autophagy, apoptosis and necrosis, in MCF-7 cells. In summary, S. graveolens extract possess anticancer activity displaying a specific cytotoxic effect on cancer cells, thus serving as a potential source of phytochemical compounds for cancer treatment.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Echiburú-Chau C,Alfaro-Lira S,Brown N,Salas CO,Cuellar M,Santander J,Ogalde JP,Rothhammer Fdoi
10.3892/ijo.2014.2302subject
Has Abstractpub_date
2014-04-01 00:00:00pages
1357-64issue
4eissn
1019-6439issn
1791-2423journal_volume
44pub_type
杂志文章abstract::Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3606
更新日期:2016-09-01 00:00:00
abstract::Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome. We have previously reported that inhibitors of histone deacetylas...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000749
更新日期:2010-10-01 00:00:00
abstract::Pancreatic cancer (PanC) is one of the most lethal malignancies, and resistance towards gemcitabine, the front-line chemotherapy, is the main cause for dismal rate of survival in PanC patients; overcoming this resistance remains a major challenge to treat this deadly malignancy. Whereas several molecular mechanisms ar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2885
更新日期:2015-04-01 00:00:00
abstract::Sixty-four colorectal carcinomas were evaluated for allelic loss of chromosomes 17p and 5q, as well as point mutation of the p53 tumor suppressor gene. Allelic loss of chromosomes 5q and 17p were found to be weakly associated, whereas point mutation of the p53 gene was found to be more strongly associated with chromos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.3.539
更新日期:1994-09-01 00:00:00
abstract::Recent studies show an increased incidence of head and neck cancers worldwide. The present study evaluated the trend in the incidence of head and neck cancers in England during 2002-2011. Data were extracted from the database of Office for National Statistics. The study population was categorised according to age, res...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2990
更新日期:2015-07-01 00:00:00
abstract::While the effects of single growth factors on endothelial cells (ECs) have been extensively studied, the importance of induction of growth factors such as PDGF-BB (platelet derived growth factor) in ECs and its impact on tumor cell functions are only partly understood. Human umbilical vein endothelial cells (HUVECs) w...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract::Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3006
更新日期:2015-07-01 00:00:00
abstract::Conventional cancer treatments are not adequate for the majority of most patients stricken with squamous cell carcinomas of the head and neck (SCCHN). Conditionally replicating adenoviruses (CRAds) represent a promising new modality for treating of neoplastic diseases, including SCCHN. Specifically, CRAd agents infect...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4682
更新日期:2019-03-01 00:00:00
abstract::Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000729
更新日期:2010-10-01 00:00:00
abstract::Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (C...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4692
更新日期:2019-03-01 00:00:00
abstract::Cytokine expression in a tumor microenvironment can impact both host defense against the tumor and tumor cell survival. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical associations with ovarian cancer. We analyzed the expression of 16 cytokine genes (IL-1α, IL-1β, I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1533
更新日期:2012-09-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3665
更新日期:2016-10-01 00:00:00
abstract::Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.6.1311
更新日期:1997-12-01 00:00:00
abstract::Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide that selectively induces apoptosis in several different types of human cancer cells. However, the potential use of LfcinB as an anticancer agent is presently limited by the need for relatively high concentrations of the peptide to trigger apoptosis. Cer...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.2.231
更新日期:1994-08-01 00:00:00
abstract::BALB/c 3T3 cells transformed by 1,1,2,2-tetrachloroethane, the most toxic chloroethane, acquired a fully malignant phenotype. They were capable of growing in soft agar, were tumorigenic when injected in athymic mice and produced pulmonary nodules after i.v. injection. Untreated BALB/c 3T3 cells were weakly tumorigenic...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.6.937
更新日期:1993-06-01 00:00:00
abstract::TGF-β-induced epithelial-mesenchymal transition (EMT) plays an important role in tumor progression. We assessed whether the TGF-β-induced EMT contributed to vasculogenic mimicry (VM) formation in glioma, we established an SHG44 cell line stably transfected with TGF-β cDNA loaded lentivirus. SB203580 was employed to in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3724
更新日期:2016-12-01 00:00:00
abstract::MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3161
更新日期:2015-11-01 00:00:00
abstract::The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract::Thirty-four children with newly diagnosed acute nonlymphoblastic leukemia were analysed for the expression of P-glycoprotein (P-170), glutathione S-transferase-pi, (GST-pi) topoisomerase II (Topo II) and the proliferation antigen Ki-67 by the streptavidin-biotin-peroxidase method. Overexpression of P-170 was present i...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.4.841
更新日期:1994-10-01 00:00:00
abstract::In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4554
更新日期:2018-11-01 00:00:00
abstract::Models of animal melanoma are still indispensable tools in oncological research because they can be studied in syngeneic hosts while human melanomas cannot. One such model is a family of melanomas which originated in 1959 from a spontaneous melanotic melanoma of the skin in Syrian hamster, the Bomirski melanomas. Curr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.2.221
更新日期:1993-02-01 00:00:00
abstract::Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2006-03-01 00:00:00
abstract::MicroRNAs (miRNAs) represent a class of small non-coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been described for several human malignancies. Herein, we show that miR-145 is down-regulated in human cancer cell line MCF-7 when compared...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract::Lipomas are the most common soft tissue tumors in adults. They often carry chromosome aberrations involving 12q13~15 leading to rearrangements of the HMGA2 gene in 12q14.3, with breakpoints occurring within or outside of the gene. Here, we present eleven lipomas and one osteochondrolipoma with a novel recurrent chromo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3099
更新日期:2015-09-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most malignant types of cancer, and is associated with high recurrence rates and a poor response to chemotherapy. Immune signatures in the microenvironment of HCC have not been well explored systematically. The aim of the present study was to identify prognostic immune sign...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.4998
更新日期:2020-05-01 00:00:00
abstract::Fanconi anemia complementation group D2 (FANCD2) is involved in the key steps of the Fanconi anemia (FA) pathway, which plays a role in the repair of DNA crosslink damage. However, the role of FANCD2 during radiotherapy for head and neck squamous cell carcinoma (HNSCC) is unclear. In this study, the HNSCC cell line HS...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.3902
更新日期:2017-03-07 00:00:00
abstract::Although Bmi1 is well established as one of the most commonly activated oncogenes, the precise role of Bmi1 during hepatocarcinogenesis remains unclear. In addition, Bmi1 provides a potential therapeutic target for the future treatment of hepatocellular carcinoma (HCC). In this stud...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1693
更新日期:2013-01-01 00:00:00
abstract::In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. 5-CQA abrogated ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3436
更新日期:2016-05-01 00:00:00