Induction of a malignant phenotype in BALB/c 3t3 cells by 1,1,2,2-tetrachloroethane.

abstract：:Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...

journal_title：International journal of oncology

authors： Huang Z,McWilliams A,Lam S,English J,McLean DI,Lui H,Zeng H

更新日期：2003-09-01 00:00:00

abstract：:Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnost...

journal_title：International journal of oncology

authors： Lee BK,Diebel E,Neukam FW,Wiltfang J,Ries J

更新日期：2001-11-01 00:00:00

abstract：:Radioiodinated meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used in management of neuroendocrine tumors. Recent studies reveal that distribution of radioiodinated MIBG in animals depends on the specific activity of this radiopharmaceutical. In order to clarify the effect of specific activit...

journal_title：International journal of oncology

authors： Farahati J,Lassmann M,Scheubeck M,Bier D,Hanscheid H,Schelper L,Grelle I,Biko J,Werner E,Graefe K,Reiners C

更新日期：1997-04-01 00:00:00

abstract：:Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety of substrates; thus a...

journal_title：International journal of oncology

authors： Vafa A,Zhang Y,Sikes RA,Marengo SR

更新日期：1998-12-01 00:00:00

abstract：:Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non‑synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterat...

journal_title：International journal of oncology

authors： Kishibuchi R,Kondo K,Soejima S,Tsuboi M,Kajiura K,Kawakami Y,Kawakita N,Sawada T,Toba H,Yoshida M,Takizawa H,Tangoku A

更新日期：2020-01-01 00:00:00

abstract：:The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection...

journal_title：International journal of oncology

authors： Ido E,Furihata M,Ohtsuki Y,Iwata J,Sonobe H

更新日期：1994-08-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:We have isolated a new -ene, named BAC, which is the human equivalent of the murine H19 gene and is highly expressed in most fetal tissues and in a variety of fresh tumors. BAC was analyzed in 130 untreated invasive carcinomas of different types. The frequency of BAC-expressing cancers as well as the level of expressi...

journal_title：International journal of oncology

authors： Doucrasy S,Coll J,Barrois M,Joubel A,Prost S,Dozier C,Stehelin D,Riou G

更新日期：1993-05-01 00:00:00

abstract：:This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, which was originally gefitinib...

journal_title：International journal of oncology

authors： Terai H,Soejima K,Yasuda H,Sato T,Naoki K,Ikemura S,Arai D,Ohgino K,Ishioka K,Hamamoto J,Kanai Y,Betsuyaku T

更新日期：2015-01-01 00:00:00

abstract：:We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tum...

journal_title：International journal of oncology

authors： Shimose S,Sugita T,Nitta Y,Kubo T,Ikuta Y,Murakami T

更新日期：2001-09-01 00:00:00

abstract：:Many traditional healing plants successfully passed several hundred years of empirical testing against specific diseases and thereby demonstrating that they are well tolerated in humans. Although quite a few ethno-pharmacological plants are applied against a variety of conditions there are still numerous plants that h...

journal_title：International journal of oncology

authors： Gridling M,Stark N,Madlener S,Lackner A,Popescu R,Benedek B,Diaz R,Tut FM,Nha Vo TP,Huber D,Gollinger M,Saiko P,Ozmen A,Mosgoeller W,De Martin R,Eytner R,Wagner KH,Grusch M,Fritzer-Szekeres M,Szekeres T,Kopp B,F

更新日期：2009-04-01 00:00:00

abstract：:The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carc...

journal_title：International journal of oncology

authors： Zhou X,Zimonjic DB,Park SW,Yang XY,Durkin ME,Popescu NC

更新日期：2008-06-01 00:00:00

abstract：:Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an ou...

journal_title：International journal of oncology

authors： Casper J,Casper S,Kohnewompner C,Bokemeyer C,Hecker H,Schmoll H

更新日期：1994-06-01 00:00:00

abstract：:The effects of pretreatment with the multidrug resistance (MDR) modulators verapamil (VPM), tamoxifen (TMX), cyclosporin A (CsA), and SDZ PSC833 (PSC) on drug sensitivity of the P-glycoprotein (Pgp) expressing human ileocecal carcinoma cell line HCT-8 is described. Following pretreatment of 2, 16 and 48 h with the ind...

journal_title：International journal of oncology

authors： Haberl I,Swatonek H,Schaufler K,Ulsperger E,Wenzl E,Theyer G,Hamilton G,Thalhammer T

更新日期：1998-05-01 00:00:00

abstract：:We assessed Stanniocalcin-1 (STC-1) mRNA expression in human normal tissues, various types of human cancer cell lines, and cancer tissues obtained during surgery. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay developed to detect STC-1 mRNA, the transcripts were detected in 20 out of 21 cancer ...

journal_title：International journal of oncology

authors： Fujiwara Y,Sugita Y,Nakamori S,Miyamoto A,Shiozaki K,Nagano H,Sakon M,Monden M

更新日期：2000-04-01 00:00:00

abstract：:Reduced expression of a cyclin-dependent kinase inhibitor, p27, has been reported to be associated with poor prognosis in several human cancers. The aim of this study was to investigate the potential role of p27 in ovarian cancer development and progression. Immunohistochemical expression of p27 was determined using 1...

journal_title：International journal of oncology

authors： Shigemasa K,Shiroyama Y,Sawasaki T,Fujii T,Nagai N,Parmley TH,O'Brien TJ,Ohama K

更新日期：2001-05-01 00:00:00

abstract：:Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7...

journal_title：International journal of oncology

authors： Kirikoshi H,Sekihara H,Katoh M

更新日期：2001-07-01 00:00:00

abstract：:Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...

journal_title：International journal of oncology

authors： Xiao S,Zhou Y,Yi W,Luo G,Jiang B,Tian Q,Li Y,Xue M

更新日期：2015-04-01 00:00:00

abstract：:Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ...

journal_title：International journal of oncology

authors： Li Z,Sun L,Lu Z,Su X,Yang Q,Qu X,Li L,Song K,Kong B

更新日期：2015-09-01 00:00:00

abstract：:The effect of reduced glutathione (GSH) and ethanol on aflatoxin B1 (AFB1)-induced DNA single strand breaks was studied in primary cultured hepatocytes. Buthionine sulfoximine (BSO) which decreased intracellular GSH to 13% of those of the control levels increased DNA fragmentation of AFB1-treated hepatocytes by over 1...

journal_title：International journal of oncology

authors： Tsutsumi N,Miyazaki K

更新日期：1994-01-01 00:00:00

abstract：:TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) preferentially induces apoptosis of cancer cells without toxicity in normal cells. TRAIL plays an important role in host immune surveillance against tumor metastasis. Cathepsin B (CB) is a mediator of apoptosis whose activity is regulated by its inhibitor...

journal_title：International journal of oncology

authors： Vigneswaran N,Wu J,Nagaraj N,Adler-Storthz K,Zacharias W

更新日期：2005-01-01 00:00:00

abstract：:In this study we investigated the relationship between the development of either HSILs (high-grade squamous intraepithelial lesions) or invasive cancers of the uterine cervix and the p53 codon 72 polymorphisms consisting of arginine (Arg)- or proline (Pro)-encoded allele in Japanese populations. Furthermore, we determ...

journal_title：International journal of oncology

authors： Kawamata Y,Mitsuhashi A,Unno Y,Kado S,Shino Y,Uesugi K,Eguchi O,Ishii J,Seki K,Sekiya S,Shirasawa H

更新日期：2002-09-01 00:00:00

abstract：:Established human breast cancer cell lines are widely used as experimental models in breast cancer research. While these cell lines and their variants share many phenotypic characteristics with human breast tumors, the extent to which they reflect the underlying molecular biology of breast cancer remains controversial...

journal_title：International journal of oncology

authors： Zhu Y,Wang A,Liu MC,Zwart A,Lee RY,Gallagher A,Wang Y,Miller WR,Dixon JM,Clarke R

更新日期：2006-12-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:Tanshinone IIA (TSIIA), a natural diterpene quinone in the traditional Chinese medicinal herb Dan-Shen (Salvia miltiorrhiza), has extensively exerted antitumor activity in cellular and animal models. However, the molecular mechanisms underlying the antitumor effects of TSIIA remain largely unknown. The in vitro effect...

journal_title：International journal of oncology

authors： Zhang J,Wang J,Jiang JY,Liu SD,Fu K,Liu HY

更新日期：2014-08-01 00:00:00

abstract：:Although the incidence of brain metastasis in gastric cancer is relatively low, its prevalence may increase with improved therapy and longer survival tumors. The molecular mechanisms underlying brain metastases are not well understood. To gain insight into the mechanism of brain metastasis, we studied differences in m...

journal_title：International journal of oncology

authors： Minn YK,Lee DH,Hyung WJ,Kim JE,Choi J,Yang SH,Song H,Lim BJ,Kim SH

更新日期：2014-12-01 00:00:00

abstract：:High consumption of soy products in some Asian countries has been linked to the low incidence of breast cancer in women. The chemopreventive effect of the soy isoflavone, genistein, has been observed through the suppression of cell proliferation, inhibition of angiogenesis and stimulation of apoptosis in breast carcin...

journal_title：International journal of oncology

authors： Valachovicova T,Slivova V,Bergman H,Shuherk J,Sliva D

更新日期：2004-11-01 00:00:00

abstract：:Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...

journal_title：International journal of oncology

authors： Ortega MA,Fraile-Martínez O,García-Honduvilla N,Coca S,Álvarez-Mon M,Buján J,Teus MA

更新日期：2020-12-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine...

journal_title：International journal of oncology

authors： Garcia-Areas R,Libreros S,Simoes M,Castro-Silva C,Gazaniga N,Amat S,Jaczewska J,Keating P,Schilling K,Brito M,Wojcikiewicz EP,Iragavarpu-Charyulu V

更新日期：2017-11-01 00:00:00