Abstract:
:We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tumor growth and lung metastasis were also inhibited more by TL-DOX and hyperthermia than by hyperthermia alone, DOX with or without hyperthermia, and TL-DOX without hyperthermia. In addition, gains in hamster body weight were not suppressed. These results suggest that the combination of TL-DOX and hyperthermia can control primary tumors and suppress lung metastasis in hamsters.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Shimose S,Sugita T,Nitta Y,Kubo T,Ikuta Y,Murakami Tdoi
10.3892/ijo.19.3.585keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
585-9issue
3eissn
1019-6439issn
1791-2423journal_volume
19pub_type
杂志文章abstract::Human squamous cell carcinomas frequently overexpress the epidermal growth factor receptor (EGFR) and this is often associated with poor prognosis in patients with these cancers. The high level of expression of the EGFR provides an important target for therapy and we and others have shown that monoclonal antibodies (m...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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pub_type: 杂志文章,已发布勘误
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journal_title:International journal of oncology
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abstract::Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...
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pub_type: 杂志文章,已发布勘误
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::TGF-beta1 stimulates proliferation of WI38 human embryo fibroblasts but inhibits that of their SV40-transformed counterparts, VA13 cells. Protein expression levels of cyclins A, D1, E and that of cdk2 and cdk4 were not affected by TGF-beta1 in either of these cells. However, TGF-beta1-treatment increases cdk2 kinase a...
journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:International journal of oncology
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pub_type: 杂志文章,评审
doi:
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doi:
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更新日期:2011-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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