Abstract:
:We examined the optimal duration of whole body hyperthermia (WBH, 41.5 degrees C) when administered simultaneously with cis-diamminedichloroplatinum(II) (CDDP) using F344 rat fibrosarcoma model. The antitumor efficacy was measured by tumor growth delay (TGD) and nephrotoxicity was evaluated by the day 5 blood urea nitrogen (BUN) associated with different duration of WBH (0.5, 1, 1.5, 2 or 3 h) with a constant dose of CDDP (2 mg/kg i.v. bolus). There was significant increase in TGD from 2.8 days to 5.4 days when the WBH duration was increased from 0.5 to 1 h (p<0.001). CDDP-induced nephrotoxicity was also enhanced by WBH. We estimated specific therapeutic efficacy (STE) for each treatment using the ratio of antitumor effect measured by TGD to nephrotoxicity calculated from the degree of increment of BUN. CDDP combined with 1 h WBH produced the best STE of 2.2. We conclude, that to maximize the therapeutic gain, a 1 h duration is optimal in the present setting of thermochemotherapy.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Makino M,Ohno S,Sakaguchi Y,Kaneko T,Strebel F,Jenkins G,Bull Jdoi
10.3892/ijo.10.2.329subject
Has Abstractpub_date
1997-02-01 00:00:00pages
329-32issue
2eissn
1019-6439issn
1791-2423journal_volume
10pub_type
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