Ciprofloxacin inhibits cell growth and synergises the effect of etoposide in hormone resistant prostate cancer cells.

abstract：:Seaweeds are commonly used as functional foods and drugs. A glycoprotein (GP) from the green alga Capsosiphon fulvescens (Cf) has been reported to have antitumor activity toward various cancer cells. We previously observed that Cf-GP induced different pathways of apoptosis in AGS human gastric cancer cells. Transformi...

journal_title：International journal of oncology

authors： Kim YM,Kim IH,Nam TJ

更新日期：2013-10-01 00:00:00

abstract：:Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...

journal_title：International journal of oncology

authors： Huang Z,McWilliams A,Lam S,English J,McLean DI,Lui H,Zeng H

更新日期：2003-09-01 00:00:00

abstract：:Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous ad...

journal_title：International journal of oncology

authors： Tsukagoshi S,Saga Y,Suzuki N,Fujioka A,Nakagawa F,Fukushima M,Suzuki M

更新日期：2003-05-01 00:00:00

abstract：:MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate...

journal_title：International journal of oncology

authors： Xu X,Xia Y,Ma J,Li W,Niu N,Li X,Tao H,Xu J,He X

更新日期：2020-08-01 00:00:00

abstract：:Lumican is a member of the small leucine-rich proteoglycan (SLRP) family and participates in the maintenance of tissue structures and tumor growth. Neuroendocrine cell tumors (NETs) including carcinoid tumors and NE cell carcinomas (NECs) possess numerous neuroendocrine (NE) granules, and differences between these tum...

journal_title：International journal of oncology

authors： Shinji S,Tajiri T,Ishiwata T,Seya T,Tanaka N,Naito Z

更新日期：2005-04-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is resistant to chemo-therapy partly due to the overexpression of the P-glycoprotein. Several tumor suppressor genes have been reported to be silenced by hypermethylation of the promoter region in RCC. We recently reported that the in vitro cytotoxicity of vinblastine (VBL) was enhanced by p...

journal_title：International journal of oncology

authors： Iwata H,Sato H,Suzuki R,Yamada R,Ichinomiya S,Yanagihara M,Okabe H,Sekine Y,Yano T,Ueno K

更新日期：2011-06-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...

journal_title：International journal of oncology

authors： Tillotson J,Darzynkiewicz Z,Cohen L,Ronai Z

更新日期：1993-07-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

journal_title：International journal of oncology

authors： Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

更新日期：2016-08-01 00:00:00

abstract：:Dickkopf-1 (Dkk1), a negative regulator of the Wnt signaling pathway, is implicated in tumorigenesis in several types of cancer. The purpose of this study was to determine the involvement of Dkk1 in oral squamous cell carcinoma (OSCC). We found that Dkk1 is frequently upregulated in OSCC-derived cell lines and primary...

journal_title：International journal of oncology

authors： Ogoshi K,Kasamatsu A,Iyoda M,Sakuma K,Yamatoji M,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K

更新日期：2011-08-01 00:00:00

abstract：:The prognosis of non-small cell lung cancer (NSCLC) patients who failed two or more treatment regimens remains very poor. We conducted a phase II study to explore the feasibility of personalized peptide vaccination (PPV), in which peptides are selected and administered based on the pre-existing host immunity before va...

journal_title：International journal of oncology

authors： Yamada T,Terazaki Y,Sakamoto S,Yoshiyama K,Matsueda S,Komatsu N,Waki K,Yamada A,Kawahara A,Kage M,Sugawara S,Yamashita Y,Sasada T,Takamori S,Itoh K

更新日期：2015-01-01 00:00:00

abstract：:Fcγ receptors (FcγRs) on effector cells are of importance for mediating antibody-dependent cellular cytotoxicity (ADCC). FcγRIIIa158valine (V)/phenylalanine (F) and FcγRIIa131histidine (H)/arginine(R) polymorphisms have been shown to relate to prognosis in antibody-treated patients. The aim of the present study was to...

journal_title：International journal of oncology

authors： Wang B,Kokhaei P,Mellstedt H,Liljefors M

更新日期：2010-12-01 00:00:00

abstract：:Protein kinase C (PKC) designates a family of kinases that regulate many essential functions including cell growth and differentiation. The tight regulation of PKC activity is crucial for maintaining normal cellular proliferation and excessive activity leads to abnormal or uncontrolled cell growth. Recent reports indi...

journal_title：International journal of oncology

authors： Sharif TR,Sharif M

更新日期：1999-02-01 00:00:00

abstract：:The cell-adhesion properties of cancer cells can be targeted to block cancer metastasis. Although cytosolic lysyl-tRNA synthetase (KRS) functions in protein synthesis, KRS on the plasma membrane is involved in cancer metastasis. We hypothesized that KRS is involved in cell adhesion-related signal transduction for cell...

journal_title：International journal of oncology

authors： Nam SH,Kang M,Ryu J,Kim HJ,Kim D,Kim DG,Kwon NH,Kim S,Lee JW

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) plays critical roles in cancer aggressiveness. We investigated the clinical and biological significance of neuropilin (NP)-1, a member of the VEGF receptor family, in colon carcinoma. We transfected NP-1-specific small interfering RNA (siRNA) into a human colon adenocarcinoma ...

journal_title：International journal of oncology

authors： Ochiumi T,Kitadai Y,Tanaka S,Akagi M,Yoshihara M,Chayama K

更新日期：2006-07-01 00:00:00

abstract：:Benzyl isothiocyanate (BITC) is known for its pharmacological properties against malignant neoplasm, including bladder cancer (BC). The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR‑99a‑5p in BITC‑treated BC cells. A quantitative polymerase chain reaction (...

journal_title：International journal of oncology

authors： Lin JF,Tsai TF,Lin YC,Chen HE,Chou KY,Hwang TI

更新日期：2019-06-01 00:00:00

abstract：:We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration o...

journal_title：International journal of oncology

authors： Yatsunami J,Aoki S,Fukuno Y,Kikuchi Y,Kawashima M,Hayashi SI

更新日期：2000-12-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making ...

journal_title：International journal of oncology

authors： Park JG,Yuan Y

更新日期：1998-04-01 00:00:00

abstract：:Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...

journal_title：International journal of oncology

authors： Nestal De Moraes G,Pereira Castro C,Salustiano EJ,Dumas ML,Costas F,Wing-Fai Lam E,Ribeiro Costa PR,Maia RC

更新日期：2019-12-01 00:00:00

abstract：:Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...

journal_title：International journal of oncology

authors： Yang YX,Li XL,Wang L,Han SY,Zhang YR,Pratheeshkumar P,Wang X,Lu J,Yin YQ,Sun LJ,Budhraja A,Hitron AJ,Ding SZ

更新日期：2013-09-01 00:00:00

abstract：:Primary liver cancer is globally the sixth most frequent cancer, and the second leading cause of cancer death and its incidence is increasing in many countries, thus, becoming serious threat to human health. Substantial research has focused on the treatment and prevention of liver cancer. However, the underlying molec...

journal_title：International journal of oncology

authors： Hu B,Sun M,Liu J,Hong G,Lin Q

更新日期：2016-04-01 00:00:00

abstract：:The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 was clearly demonstrated in two independent PLAG1 transgenic mouse founders, in which PLAG1 expression could be targeted to different tissues usin...

journal_title：International journal of oncology

authors： Declercq J,Van Dyck F,Van Damme B,Van de Ven WJ

更新日期：2008-05-01 00:00:00

abstract：:Postoperative adjuvant chemotherapy reportedly improves advanced colorectal cancer patients' survival, however, it is necessary to assess what regimens are useful. Doxifluridine (5'-DFUR) is an intermediate of capecitabine approved in Europe and USA to treat metastatic colorectal cancer. 5'-DFUR is metabolized to 5-fl...

journal_title：International journal of oncology

authors： Koda K,Miyazaki M,Sarashina H,Suwa T,Saito N,Suzuki M,Ogawa K,Watanabe S,Kodaira S,Nakazato H

更新日期：2003-07-01 00:00:00

abstract：:Low concentrations of monoclonal antibodies (mAb) specific for the CD3 component of the T cell receptor complex (TcR) may be both immunosuppressive or potent activators of T cell function in vitro depending upon the experimental situation. The anti-CD3 mAb OKT3 is imnmunosuppressive at high doses (5 mg/day for 10 to 1...

journal_title：International journal of oncology

authors： Hollingworth J,Catterick R,Horsburgh T,Veitch P,Bell P

更新日期：1994-09-01 00:00:00

abstract：:The identification of cell surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene expression analysis. The data indicate that there a...

journal_title：International journal of oncology

authors： Teicher BA

更新日期：2007-02-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade is a critical component in the regulation of cell survival and proliferation decisions. In breast carcinoma cells, activation of the p38-MAPK member of this family occurs in response to pro-inflammatory cytokines and cellular stress. The involvement of p38-MAPK in th...

journal_title：International journal of oncology

authors： Weldon CB,Parker AP,Patten D,Elliott S,Tang Y,Frigo DE,Dugan CM,Coakley EL,Butler NN,Clayton JL,Alam J,Curiel TJ,Beckman BS,Jaffe BM,Burow ME

更新日期：2004-06-01 00:00:00

abstract：:Tanshinone IIA (TSIIA), a natural diterpene quinone in the traditional Chinese medicinal herb Dan-Shen (Salvia miltiorrhiza), has extensively exerted antitumor activity in cellular and animal models. However, the molecular mechanisms underlying the antitumor effects of TSIIA remain largely unknown. The in vitro effect...

journal_title：International journal of oncology

authors： Zhang J,Wang J,Jiang JY,Liu SD,Fu K,Liu HY

更新日期：2014-08-01 00:00:00

abstract：:It is well established that the tumor microenvironment plays a major role in the aggressive behavior of malignant solid tumors. Among cell types associated with tumor microenvironment, tumor-associated macrophages (TAMs) are the most influential for tumor progression. Breast cancer is characterized by having a large p...

journal_title：International journal of oncology

authors： Obeid E,Nanda R,Fu YX,Olopade OI

更新日期：2013-07-01 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-...

journal_title：International journal of oncology

authors： Ouelaa-Benslama R,De Wever O,Hendrix A,Sabbah M,Lambein K,Land D,Prévost G,Bracke M,Hung MC,Larsen AK,Emami S,Gespach C

更新日期：2012-07-01 00:00:00

abstract：:Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...

journal_title：International journal of oncology

authors： Weber R,Meister M,Muley T,Thomas M,Sültmann H,Warth A,Winter H,Herth FJF,Schneider MA

更新日期：2019-02-01 00:00:00