Abstract:
:Dickkopf-1 (Dkk1), a negative regulator of the Wnt signaling pathway, is implicated in tumorigenesis in several types of cancer. The purpose of this study was to determine the involvement of Dkk1 in oral squamous cell carcinoma (OSCC). We found that Dkk1 is frequently upregulated in OSCC-derived cell lines and primary OSCCs compared with normal counterparts. Unexpectedly, Dkk1-positive cases were correlated significantly (P<0.05) with a low risk of regional lymph node metastasis. We also found that cellular migration and invasiveness increased in Dkk1 knockdown cells and decreased in Dkk1 overexpressed cells. Furthermore, we investigated the relationship between the expression of Dkk1 and distribution of β-catenin in OSCC cells, since the Wnt signaling pathway is related closely to β-catenin. Whereas alteration of the β-catenin levels was not observed in each subcellular fractionation, the phosphorylated β-catenin levels in nuclei increased in Dkk1 knockdown cells and decreased in Dkk1 overexpressed cells. These data indicated that the high phosphorylation level of β-catenin in nuclei was correlated with a high risk of tumor invasiveness. The current study suggested that Dkk1 plays an important role in regulating cellular migration and invasiveness, making Dkk1 a potential biomarker for early detection of lymph node metastasis in OSCCs.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Ogoshi K,Kasamatsu A,Iyoda M,Sakuma K,Yamatoji M,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa Kdoi
10.3892/ijo.2011.1046subject
Has Abstractpub_date
2011-08-01 00:00:00pages
329-36issue
2eissn
1019-6439issn
1791-2423journal_volume
39pub_type
杂志文章abstract::SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta‑analysis based on multiple...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5048
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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journal_title:International journal of oncology
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