Abstract:
:Thirty patients who underwent hepatectomy for the treatment of hepatocellular carcinoma (HCC) were examined for expression of HLA class I antigens on HCC cells by flow cytometry. The expression was found significantly lower in cases of stage IV compared with those of stage I or stage II (p<0.05), and in cases of intrahepatic metastases compared with those without metastases (p<0.001). In cases of non-curative hepatectomy, the expression of HLA class I antigens was lower compared with those treated by curative resection. Postoperative cumulative disease-free survival rates were well correlated with the expression rate of HLA class I antigens (p<0.05). Expression of HLA class I antigens on HCC may indicate low malignancy and better prognosis.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Nishibe M,Une Y,Kobayashi M,Kuramitsu Y,Hosokawa M,Uchino Jdoi
10.3892/ijo.8.6.1243subject
Has Abstractpub_date
1996-06-01 00:00:00pages
1243-7issue
6eissn
1019-6439issn
1791-2423journal_volume
8pub_type
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