CYP1A1 is a target of miR-892a-mediated post-transcriptional repression.

abstract：:Radioiodinated meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used in management of neuroendocrine tumors. Recent studies reveal that distribution of radioiodinated MIBG in animals depends on the specific activity of this radiopharmaceutical. In order to clarify the effect of specific activit...

journal_title：International journal of oncology

authors： Farahati J,Lassmann M,Scheubeck M,Bier D,Hanscheid H,Schelper L,Grelle I,Biko J,Werner E,Graefe K,Reiners C

更新日期：1997-04-01 00:00:00

abstract：:VSELs are a population of rare Oct-4+CXCR4+ CD133+lin-CD45- cells that are deposited during early embryogenesis in developing organs/tissues as a reserve population of pluripotent stem cells for regeneration. We reported recently that they are mobilized into peripheral blood during acute myocardial infarction (AMI) in...

journal_title：International journal of oncology

authors： Wojakowski W,Tendera M,Kucia M,Zuba-Surma E,Milewski K,Wallace-Bradley D,Kazmierski M,Buszman P,Hrycek E,Cybulski W,Kaluza G,Wieczorek P,Ratajczak J,Ratajczak MZ

更新日期：2010-08-01 00:00:00

abstract：:An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in...

journal_title：International journal of oncology

authors： Hwang KA,Kang NH,Yi BR,Lee HR,Park MA,Choi KC

更新日期：2013-02-01 00:00:00

abstract：:We investigated the effect of stabilized Fab oligomerization by disuccinimidyl suberate on tumor uptake in a pancreatic carcinoma xenograft model in nude mice. Recombinant mouse/human chimeric Fab of the anti-carcinoembryonic antigen (CEA) monoclonal antibody A10, which was previously shown to react specifically with ...

journal_title：International journal of oncology

authors： Kamigaki T,Ajiki T,Yamamoto M,Kuroda Y

更新日期：1999-01-01 00:00:00

abstract：:Angiogenesis is increased in various human cancers, including head and neck squamous cell carcinoma (HNSCC), and correlates with tumor progression and metastasis. Vascular endothelial growth factor (VEGF) has been shown to be a key regulator of angiogenesis. We determined whether VEGF antisense oligonucleotide treatme...

journal_title：International journal of oncology

authors： Riedel F,Götte K,Li M,Hörmann K,Grandis JR

更新日期：2003-09-01 00:00:00

abstract：:Gene expression of dihydropyrimidine dehydrogenase (DPD) and newly multidrug resistance-associated protein (MRP) was found to correlate well with primary 5-FU resistance in 7 human gastrointestinal cancer cell lines. Although mRNA and protein levels of thymidylate synthase (TS) did not relate to the resistance, 5-FU t...

journal_title：International journal of oncology

authors： Kirihara Y,Yamamoto W,Toge T,Nishiyama M

更新日期：1999-03-01 00:00:00

abstract：:We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two other non-small cell lung cancer (NSCLC) cell lines: NCI-H1299 and A549 cells (IC50 values = 7.6 and 16.1 nM, respectively). Our experiments further showed tha...

journal_title：International journal of oncology

authors： Choi JY,Hong WG,Cho JH,Kim EM,Kim J,Jung CH,Hwang SG,Um HD,Park JK

更新日期：2015-10-01 00:00:00

abstract：:CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baical...

journal_title：International journal of oncology

authors： Ohkoshi E,Umemura N

更新日期：2017-02-01 00:00:00

abstract：:Spindle cell tumors are clinically heterogeneous but morphologically similar neoplasms that can occur anywhere, mostly in adult patients. They are treated primarily with surgery to which is often added adjuvant or neoadjuvant radiation. Sub-classification of spindle cell sarcomas requires integration of histology, cli...

journal_title：International journal of oncology

authors： Panagopoulos I,Bjerkehagen B,Gorunova L,Berner JM,Boye K,Heim S

更新日期：2014-11-01 00:00:00

abstract：:Autocrine fibroblast growth factor (FGF) signaling was genetically manipulated in human gliomas by an adenovirus-mediated strategy. Antisense inhibition of endogenous basic FGF (bFGF) expression showed inhibition of the proliferation of human glioma cells (U251MG, NMC-G1) without promoting apoptosis. The reduction in ...

journal_title：International journal of oncology

authors： Aoki T,Kato S,Fox JC,Okamoto K,Sakata K,Morimatsu M,Shigemori M

更新日期：2002-09-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that transmits signals through G-protein-coupled receptors to control cellular differentiation, survival, and several functions of immune cells. S1P is a chemoattractant for NK cells, which are critical members of the immunological tumor surveillance machinery....

journal_title：International journal of oncology

authors： Lagadari M,Lehmann K,Ziemer M,Truta-Feles K,Berod L,Idzko M,Barz D,Kamradt T,Maghazachi AA,Norgauer J

更新日期：2009-01-01 00:00:00

abstract：:We purified and identified eight xanthones from mangosteen (Garcinia mangostana L.) and investigated whether these compounds inhibited the activities of mammalian DNA polymerases (Pols) and human DNA topoisomerases (Topos). β-Mangostin was the strongest inhibitor of both mammalian Pols and human Topos among the isolat...

journal_title：International journal of oncology

authors： Onodera T,Takenaka Y,Kozaki S,Tanahashi T,Mizushina Y

更新日期：2016-03-01 00:00:00

abstract：:Multi-drug resistance (MDR) limits the effectiveness of chemotherapy. P-glycoprotein encoded by the MDR1 gene, is known to be implicated in MDR phenotype, but other factors could be determinant in MDR. The aim of this study was to investigate new molecular factors potentially associated with the MDR phenotype using a ...

journal_title：International journal of oncology

authors： Visentin M,Simula MP,Sartor F,Petrucco A,De Re V,Toffoli G

更新日期：2009-05-01 00:00:00

abstract：:We examined the relationships among nuclear DNA content, tumor origin, nuclear size, and prognosis in squamous cell lung cancer. Central tumors had significantly higher DNA aneuploidy (83%, p<0.01) and DNA indices (1.65+/-0.40, p<0.01) than did peripheral tumors (40%, 1.29+/-0.37, respectively). All six women in the s...

journal_title：International journal of oncology

authors： Miyamoto H,Isobe H,Akita H,Ishiguro A,Endo T,Inoue S,Kawakami Y

更新日期：1992-08-01 00:00:00

abstract：:Dendritic cells play a major role in cellular immunity. The crucial steps of antigen presentation and processing by DCs may be limiting factors for adoptive cellular immunotherapy. Here, we investigated whether hyperthermia of human hepatocellular carcinoma (HCC) cells induces enhanced cytotoxic cellular immune respon...

journal_title：International journal of oncology

authors： Schueller G,Stift A,Friedl J,Dubsky P,Bachleitner-Hofmann T,Benkoe T,Jakesz R,Gnant M

更新日期：2003-06-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a member of the sirtuin deacetylases (sirtuins), which are derivatives of the yeast Silent information regulator 2 (Sir2) protein. SIR2 and its mammalian derivatives play a central role in epigenetic gene silencing, recombination, metabolism, cell differentiation and in the regulation of aging. In...

journal_title：International journal of oncology

authors： Mahlknecht U,Ho AD,Voelter-Mahlknecht S

更新日期：2006-02-01 00:00:00

abstract：:Extrahepatic cholangiocarcinoma (CC) is an aggressive malignancy with dismal prognosis and characterized by early invasion, metastasis and postoperative recurrence. Therefore, understanding the main molecular mechanisms of this malignancy is the key for the development of novel and effective therapeutic strategies for...

journal_title：International journal of oncology

authors： Qiang Y,Wang F,Yan S,Zhang H,Zhu L,Chen Z,Tu F,Wang D,Wang G,Wang W,Chen Z

更新日期：2015-01-01 00:00:00

abstract：:A slowly proliferating cell fraction in tumors shows reduced sensitivity to cell cycle-dependent anticancer agents. To understand the molecular basis of drug resistance observed in brain tumors, we examined the relationship between alteration of p16, a cyclin dependent kinase inhibitor whose functions are frequently l...

journal_title：International journal of oncology

authors： Iwadate Y,Mochizuki S,Fujimoto S,Namba H,Sakiyama S,Tagawa M,Yamaura A

更新日期：2000-09-01 00:00:00

abstract：:Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and is highly resistant to conventional cancer therapy. A better understanding of the regulatory mechanisms which control the growth of this deadly malignancy are urgently needed to develop more effective cancer intervention strategies. Recent studies h...

journal_title：International journal of oncology

authors： Schuller HM,Plummer HK 3rd,Bochsler PN,Dudric P,Bell JL,Harris RE

更新日期：2001-09-01 00:00:00

abstract：:Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...

journal_title：International journal of oncology

authors： Naujocks G,Schmitz A,Schramm J,Wiestler O,Schirrmacher V

更新日期：1995-04-01 00:00:00

abstract：:Gene amplification is a frequent event in lung cancer, specifically in squamous cell lung carcinoma. Recently, we reported amplifications on chromosomal bands 3q26.1-q26.3 with the genes BCHE and SLC2A2 amplified in 40% of squamous cell lung carcinomas. Here, we identified an amplified domain within chromosomal bands ...

journal_title：International journal of oncology

authors： Rácz A,Brass N,Höfer M,Sybrecht GW,Remberger K,Meese EU

更新日期：2000-07-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...

journal_title：International journal of oncology

authors： Fan X,Wei J,Xiong H,Liu X,Benichou S,Gao X,Liu L

更新日期：2015-10-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:Voltage-gated potassium (Kv) channels play important roles in differentiation and growth of non-excitable cells. Inhibition of these channels is also known to suppress proliferation of various cancer cells. Here we examine expression of K+ channel subunit genes in various uterine cancer cells and their roles in cell p...

journal_title：International journal of oncology

authors： Suzuki T,Takimoto K

更新日期：2004-07-01 00:00:00

abstract：:There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the risk of breast cancer with respect to circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding...

journal_title：International journal of oncology

authors： Kahán Z,Gardi J,Nyári T,Földesi I,Hajnal-Papp R,Ormándi K,Lázár G,Thurzó L,Schally AV

更新日期：2006-07-01 00:00:00

abstract：:Chemotherapy is an important treatment option for gastric cancer (GC); however, chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR). In our previous studies, microRNA (miR)‑874 was demonstrated to serve an important role in tumour growth, apoptosis and angiogenesis. In the presen...

journal_title：International journal of oncology

authors： Huang H,Tang J,Zhang L,Bu Y,Zhang X

更新日期：2018-12-01 00:00:00

abstract：:Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...

journal_title：International journal of oncology

authors： Shaughnessy M,Lamuraglia G,Klebanov N,Ji Z,Rajadurai A,Kumar R,Flaherty K,Tsao H

更新日期：2019-11-01 00:00:00

abstract：:Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...

journal_title：International journal of oncology

authors： Tennstedt P,Köster P,Brüchmann A,Mirlacher M,Haese A,Steuber T,Sauter G,Huland H,Graefen M,Schlomm T,Minner S,Simon R

更新日期：2012-01-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00