miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.

abstract：:Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major rol...

journal_title：International journal of oncology

authors： Kawaguchi M,Banno K,Yanokura M,Kobayashi Y,Kishimi A,Ogawa S,Kisu I,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2009-11-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00

abstract：:Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG i...

journal_title：International journal of oncology

authors： Park JS,Khoi PN,Joo YE,Lee YH,Lang SA,Stoeltzing O,Jung YD

更新日期：2013-03-01 00:00:00

abstract：:There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the risk of breast cancer with respect to circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding...

journal_title：International journal of oncology

authors： Kahán Z,Gardi J,Nyári T,Földesi I,Hajnal-Papp R,Ormándi K,Lázár G,Thurzó L,Schally AV

更新日期：2006-07-01 00:00:00

abstract：:Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulation of hTERT. All-trans retinoic acid (ATRA) induces differentiation in...

journal_title：International journal of oncology

authors： Love WK,Berletch JB,Andrews LG,Tollefsbol TO

更新日期：2008-03-01 00:00:00

abstract：:It has been reported that MUC-1 molecules devoid of the tandem repeat region (MUC-1/Y) are detected preferentially in carcinoma cells and are associated with their progression. However, its clinical significance is still unknown. We constructed a mouse colon adenocarcinoma cell line (MC-38) transduced with either MUC-...

journal_title：International journal of oncology

authors： Akagi J,Takai E,Tamori Y,Nakagawa K,Ogawa M

更新日期：2001-05-01 00:00:00

abstract：:This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...

journal_title：International journal of oncology

authors： Van den Neste E,Cardoen S,Offner F,Bontemps F

更新日期：2005-10-01 00:00:00

abstract：:Primary liver cancer is globally the sixth most frequent cancer, and the second leading cause of cancer death and its incidence is increasing in many countries, thus, becoming serious threat to human health. Substantial research has focused on the treatment and prevention of liver cancer. However, the underlying molec...

journal_title：International journal of oncology

authors： Hu B,Sun M,Liu J,Hong G,Lin Q

更新日期：2016-04-01 00:00:00

abstract：:The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

journal_title：International journal of oncology

authors： Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

更新日期：1997-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) represent a class of small non-coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been described for several human malignancies. Herein, we show that miR-145 is down-regulated in human cancer cell line MCF-7 when compared...

journal_title：International journal of oncology

authors： Wang S,Bian C,Yang Z,Bo Y,Li J,Zeng L,Zhou H,Zhao RC

更新日期：2009-05-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that transmits signals through G-protein-coupled receptors to control cellular differentiation, survival, and several functions of immune cells. S1P is a chemoattractant for NK cells, which are critical members of the immunological tumor surveillance machinery....

journal_title：International journal of oncology

authors： Lagadari M,Lehmann K,Ziemer M,Truta-Feles K,Berod L,Idzko M,Barz D,Kamradt T,Maghazachi AA,Norgauer J

更新日期：2009-01-01 00:00:00

abstract：:Liposarcoma (LPS) is one of the most frequently reported type of soft‑tissue sarcoma (STS). Well‑differentiated (WD) LPS and dedifferentiated (DD) LPS are the two most common subtypes. Chemotherapy has been considered to be ineffective in LPS, and novel treatment agents are thus necessary. In this study, we reanalyzed...

journal_title：International journal of oncology

authors： Yen CC,Chen SC,Hung GY,Wu PK,Chua WY,Lin YC,Yen CH,Chen YC,Wang JY,Yang MH,Chao Y,Chang MC,Chen WM

更新日期：2019-10-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is resistant to chemo-therapy partly due to the overexpression of the P-glycoprotein. Several tumor suppressor genes have been reported to be silenced by hypermethylation of the promoter region in RCC. We recently reported that the in vitro cytotoxicity of vinblastine (VBL) was enhanced by p...

journal_title：International journal of oncology

authors： Iwata H,Sato H,Suzuki R,Yamada R,Ichinomiya S,Yanagihara M,Okabe H,Sekine Y,Yano T,Ueno K

更新日期：2011-06-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00

abstract：:Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...

journal_title：International journal of oncology

authors： Dittmer A,Lange T,Leyh B,Dittmer J

更新日期：2020-01-01 00:00:00

abstract：:Many traditional healing plants successfully passed several hundred years of empirical testing against specific diseases and thereby demonstrating that they are well tolerated in humans. Although quite a few ethno-pharmacological plants are applied against a variety of conditions there are still numerous plants that h...

journal_title：International journal of oncology

authors： Gridling M,Stark N,Madlener S,Lackner A,Popescu R,Benedek B,Diaz R,Tut FM,Nha Vo TP,Huber D,Gollinger M,Saiko P,Ozmen A,Mosgoeller W,De Martin R,Eytner R,Wagner KH,Grusch M,Fritzer-Szekeres M,Szekeres T,Kopp B,F

更新日期：2009-04-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) and acute myeloid leukemia are the major causes of mortality and morbidity in Fanconi anemia (FA) patients. The objective of this study was to investigate the antineoplastic activity of PB, an antineoplastic nutrient mixture (containing quercetin, curcumin, green tea, cruc...

journal_title：International journal of oncology

authors： Roomi MW,Kalinovsky T,Roomi NW,Niedzwiecki A,Rath M

更新日期：2015-05-01 00:00:00

abstract：:We examined the gene expression profiles of esophageal squamous cell carcinomas (ESCCs) with respect to degree of invasive depth and lymph node (LN) involvement in a large cohort. We used high-density oligonucleotide microarrays to examine the expression of 22,115 genes in 54 ESCCs and 11 non-cancerous esophageal tiss...

journal_title：International journal of oncology

authors： Sato T,Iizuka N,Hamamoto Y,Yoshino S,Abe T,Takeda S,Uchimura S,Miyamoto T,Sei F,Hamada K,Yamada-Okabe H,Oka M

更新日期：2006-05-01 00:00:00

abstract：:The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated. The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR ex...

journal_title：International journal of oncology

authors： Murati A,Arnoulet C,Lafage-Pochitaloff M,Adélaide J,Derré M,Slama B,Delaval B,Popovici C,Vey N,Xerri L,Mozziconacci MJ,Boulat O,Sainty D,Birnbaum D,Chaffanet M

更新日期：2005-06-01 00:00:00

abstract：:Selenium is considered to be one of the most promising micronutrients for cancer prevention and therapy, based on evidence from epidemiological studies, laboratory-based research and clinical trial intervention. There are ample reports of selenium methionine and sodium selenite's ability to induce apoptosis in various...

journal_title：International journal of oncology

authors： Rooprai HK,Kyriazis I,Nuttall RK,Edwards DR,Zicha D,Aubyn D,Davies D,Gullan R,Pilkington GJ

更新日期：2007-05-01 00:00:00

abstract：:Intracellular antigens are presented to CD8+ T cells through major histocompatibility complex (MHC) class I molecule. For stable MHC class I expression, several molecules as well as the MHC molecule itself have to express simultaneously and function well. To determine a gene associated with MHC class I surface express...

journal_title：International journal of oncology

authors： Kang JK,Yoon SJ,Kim NK,Heo DS

更新日期：2000-06-01 00:00:00

abstract：:Metastatic disease commonly occurs in the spine and incidence is likely to increase secondary to improved survival rates in many cancer patients. Despite published research on instability in patients with metastatic disease of the thoracolumbar spine, controversy exists regarding risk factors for instability and indic...

journal_title：International journal of oncology

authors： Weber MH,Burch S,Buckley J,Schmidt MH,Fehlings MG,Vrionis FD,Fisher CG

更新日期：2011-01-01 00:00:00

abstract：:Tumour cell surfaces possess a cell surface protease (GB), which can be recognised by a cytoplasmic inhibitor protein prepared from cultured tumour cells. This enzyme inhibitor complex has been shown to be reversibly dissociated by 10-(4)M sodium dodecyl sulphate. Sections of frozen tumour tissue were used to provide ...

journal_title：International journal of oncology

authors： Steven F,Griffin M,Blakey D

更新日期：1992-06-01 00:00:00

abstract：:This retrospective study looks at the differences between adolescents (15-19 years) and young adults (20-25 years), diagnosed with Hodgkin lymphoma and treated at the same adult institution. Outcome according to risk category was evaluated, and although there were no significant differences in the whole cohort, or low...

journal_title：International journal of oncology

authors： Herbertson RA,Evans LS,Hutchinson J,Horsman J,Hancock BW

更新日期：2008-07-01 00:00:00

abstract：:Transforming growth factor-β receptor II (TGFBR2) is implicated in various types of cancer. Most molecules involved in the TGF-β pathway can be degraded by one or more microRNAs (miRNAs). In the present study, we show that miRNA plays an important role in downregulating TGFBR2 expression in Ewing's sarcoma (ES) cells....

journal_title：International journal of oncology

authors： Kawano M,Tanaka K,Itonaga I,Iwasaki T,Tsumura H

更新日期：2017-12-01 00:00:00

abstract：:Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the contribution of endogenous CCK to tumor growth is unknown. The purpose of this study was to evaluate the role of endogenous CCK on autocrine growth of pancreatic cancer...

journal_title：International journal of oncology

authors： Matters GL,McGovern C,Harms JF,Markovic K,Anson K,Jayakumar C,Martenis M,Awad C,Smith JP

更新日期：2011-03-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of lysyl oxidase‑like 2 (LOXL2) on the invasion, migration and epithelial‑to‑mesenchymal transition (EMT) of renal cell carcinoma (RCC) cells through the steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway. RCC tissues and adjacen...

journal_title：International journal of oncology

authors： Hong X,Yu JJ

更新日期：2019-05-01 00:00:00

abstract：:Lipomas are the most common soft tissue tumors in adults. They often carry chromosome aberrations involving 12q13~15 leading to rearrangements of the HMGA2 gene in 12q14.3, with breakpoints occurring within or outside of the gene. Here, we present eleven lipomas and one osteochondrolipoma with a novel recurrent chromo...

journal_title：International journal of oncology

authors： Panagopoulos I,Gorunova L,Bjerkehagen B,Lobmaier I,Heim S

更新日期：2015-09-01 00:00:00