Modulation of proliferation and cellular-changes of human prostatic-cancer cells by activated lymphocytes.

abstract：:The perineural invasion (PNI) of malignant tumors is a form of tumor progression in which cancer cells encroach along nerves. PNI hinders curative resection. Residual tumor cells in or around nerves can bring about local recurrence, infiltration and metastasis. This behavior is usually associated with a poor clinical ...

journal_title：International journal of oncology

authors： Zhang M,Zhu ZL,Gao XL,Wu JS,Liang XH,Tang YL

更新日期：2018-05-01 00:00:00

abstract：:Currently, it is not entirely clear whether hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of COX-2 expression and epithelial-to-mesenchymal transition (EMT), and whether these events affect the prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolizati...

journal_title：International journal of oncology

authors： Huang M,Wang L,Chen J,Bai M,Zhou C,Liu S,Lin Q

更新日期：2016-05-01 00:00:00

abstract：:The purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (IAPs), their inhibitor, Smac, and the focal adhesion kinase (FAK) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, NCCIT. We demonstrated that specifically in laminin-adheren...

journal_title：International journal of oncology

authors： Andjilani M,Droz JP,Benahmed M,Tabone E

更新日期：2006-02-01 00:00:00

abstract：:The DNA topoisomerase I inhibitor beta-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of beta-lapachone on the growth of human prostate epithelial cells. Upon treatment with beta-lapachon...

journal_title：International journal of oncology

authors： Choi YH,Kim MJ,Lee SY,Lee YN,Chi GY,Eom HS,Kim ND,Choi BT

更新日期：2002-12-01 00:00:00

abstract：:Neuroblastoma is a paediatric solid tumor characterized by recurrent genomic abnormalities of prognostic importance. One of the most commonly observed abnormalities is deletion of the short arm of chromosome 1 and reduced expression of cancer related genes in this chromosomal arm. The long isoform of the retinoblastom...

journal_title：International journal of oncology

authors： Geli J,Kiss N,Kogner P,Larsson C

更新日期：2010-11-01 00:00:00

abstract：:Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...

journal_title：International journal of oncology

authors： Wada H,Yamamoto H,Kim C,Uemura M,Akita H,Tomimaru Y,Hama N,Kawamoto K,Kobayashi S,Eguchi H,Umeshita K,Doki Y,Mori M,Nagano H

更新日期：2014-09-01 00:00:00

abstract：:Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this gene in a large series of primary tumors located outside the gastrointestinal tract which have been associated with loss ...

journal_title：International journal of oncology

authors： Verbeek W,Spirin K,Hatta Y,Miller C,Kawamata N,Takeuchi S,Koike M,Asou H,Simpson J,Koeffler H

更新日期：1997-02-01 00:00:00

abstract：:Hypericin is used as a powerful naturally occurring photosensitizer in photodynamic therapy (PDT). Activated by visible light, it kills tumour cells and tissues via generation of reactive oxygen species (ROS). Depending on the protocol, apoptotic cell death can be achieved very effectively by hypericin-PDT. To analyze...

journal_title：International journal of oncology

authors： Sanovic R,Krammer B,Grumboeck S,Verwanger T

更新日期：2009-10-01 00:00:00

abstract：:Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...

journal_title：International journal of oncology

authors： Kondo R,Ishino K,Wada R,Takata H,Peng WX,Kudo M,Kure S,Kaneya Y,Taniai N,Yoshida H,Naito Z

更新日期：2019-04-01 00:00:00

abstract：:Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...

journal_title：International journal of oncology

authors： Hardell L,Fredrikson M,Axelson O

更新日期：1996-03-01 00:00:00

abstract：:Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types of cancer. The purpose of this study was to evaluate whether autoantibodies to IGFBP-2 can be used as diagnostic markers in lung cancer. The re...

journal_title：International journal of oncology

authors： Zhang Y,Ying X,Han S,Wang J,Zhou X,Bai E,Zhang J,Zhu Q

更新日期：2013-01-01 00:00:00

abstract：:The treatment of glioblastoma is unsatisfactory. Improved understanding of the biological effects of treatment, together with development of new tools to predict outcome of the initiated treatment are therefore of great need. Vandetanib (ZD6474) is mainly a vascular endothelial growth factor (VEGF) and epidermal growt...

journal_title：International journal of oncology

authors： Wibom C,Sandström M,Henriksson R,Antti H,Johansson M,Bergenheim AT

更新日期：2010-10-01 00:00:00

abstract：:Gene amplifications occurring in the q13 band of chromosome 11 are frequently observed in head and neck squamous cell carcinomas. In order to determine the relative frequency of amplification in 5 distinct 11q13 loci and their relation with clinical data, tumor DNAs from 31 patients - including 26 who had undergone ne...

journal_title：International journal of oncology

authors： Parise O,Janot F,Guerry R,Fortin A,Luboinski B,Tursz T,Schwaab G,Busson P

更新日期：1994-08-01 00:00:00

abstract：:Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...

journal_title：International journal of oncology

authors： Tait L,Dawson P,Wolman S,Galea K,Miller F

更新日期：1996-08-01 00:00:00

abstract：:Neuroblastoma (NB) is one of the most common extracranial solid tumors in children, which has complex molecular mechanisms. Increasing evidence has suggested that long noncoding RNAs (lncRNAs) account for NB pathogenesis. However, the function of small nucleolar RNA host gene 16 (SNHG16) in NB is currently unclear. In...

journal_title：International journal of oncology

authors： Yu Y,Chen F,Yang Y,Jin Y,Shi J,Han S,Chu P,Lu J,Tai J,Wang S,Yang W,Wang H,Guo Y,Ni X

更新日期：2019-07-01 00:00:00

abstract：:We investigated the relationship between cell growth and differentiation and COX-2 expression in oral squamous cell carcinoma (SCC) in vitro and in vivo. Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and in...

journal_title：International journal of oncology

authors： Kuroda J,Urade M,Kishimoto H,Noguchi K,Hashitani S,Sakurai K,Nishimura N,Hashimoto-Tamaoki T

更新日期：2005-02-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00

abstract：:The peptide hormone, GnRH has been hypothesized to play a direct antitumoral role in certain kinds of breast cancer. This direct effect is considered to function via high affinity membrane receptors to GnRH that have been demonstrated in tumors. However, no routine assay for GnRH receptors exist limiting further resea...

journal_title：International journal of oncology

authors： Reshkin S,Pezzetta A,Albarani V,Schittulli F,Paradiso A

更新日期：1995-08-01 00:00:00

abstract：:Although peritoneal lavage with distilled water performed after surgery prevents peritoneal seeding, cancer cells may avoid rupture under mild hypotonicity through regulatory volume decrease (RVD), which is the homeostatic regulation of ion and water transport. The aim of the present study was to investigate the effec...

journal_title：International journal of oncology

authors： Shiozaki A,Yamazato Y,Kosuga T,Kudou M,Shoda K,Arita T,Konishi H,Komatsu S,Kubota T,Fujiwara H,Okamoto K,Marunaka Y,Otsuji E

更新日期：2019-10-01 00:00:00

abstract：:The tumor suppressor protein p53 is one of the most important manipulators of the cell cycle. By interaction with targets such as WAF1/CIP1, mdm2 or GADD45 p53 functions as a negative or positive regulator of the cell cycle. After DNA damage p53 is implicated in growth arrest of cells in the G(1) phase of the cell cyc...

journal_title：International journal of oncology

authors： Gotz C,Montenarh M

更新日期：1995-05-01 00:00:00

abstract：:The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...

journal_title：International journal of oncology

authors： Moriya S,Komatsu S,Yamasaki K,Kawai Y,Kokuba H,Hirota A,Che XF,Inazu M,Gotoh A,Hiramoto M,Miyazawa K

更新日期：2015-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:Breast cancer is the second cause of cancer‑related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against brea...

journal_title：International journal of oncology

authors： Echiburú-Chau C,Alfaro-Lira S,Brown N,Salas CO,Cuellar M,Santander J,Ogalde JP,Rothhammer F

更新日期：2014-04-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...

journal_title：International journal of oncology

authors： Ratajczak-Wielgomas K,Grzegrzolka J,Piotrowska A,Matkowski R,Wojnar A,Rys J,Ugorski M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...

journal_title：International journal of oncology

authors： Umene K,Yanokura M,Banno K,Irie H,Adachi M,Iida M,Nakamura K,Nogami Y,Masuda K,Kobayashi Y,Tominaga E,Aoki D

更新日期：2015-04-01 00:00:00

abstract：:Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with liver metastases are candidates for potentially curative surgical resection. The treatment of patients with unresectable liver tumors is a major clinical probl...

journal_title：International journal of oncology

authors： Cai SR,Garbow JR,Culverhouse R,Church RD,Zhang W,Shannon WD,McLeod HL

更新日期：2005-07-01 00:00:00

abstract：:The FHIT gene, at 3p14.2, has been suggested to form a molecular target to damage induced by human lung carcinogens. We examined aberrant expression of the Fhit protein and allele loss at the FHIT gene in a series of lung cancer cases, mainly of non-small cell carcinoma (NSCLC) histology. We had detailed data on tobac...

journal_title：International journal of oncology

authors： Pylkkanen L,Wolff H,Stjernvall T,Tuominen P,Sioris T,Karjalainen A,Anttila S,Husgafvel-Pursiainen K

更新日期：2002-02-01 00:00:00

abstract：:The ability of lonidamine (LND), an energolytic derivative of indazol-carboxylic acid, to modulate the cytotoxic activity of idarubicin (IDA) and doxorubicin (DX) was investigated in two human lymphoma cell lines (H9 and U937). A different pattern of interaction between the drugs was observed as a function of treatmen...

journal_title：International journal of oncology

authors： Zaffaroni N,Villa R,Gornati D,Folini M,Silvestrini R

更新日期：1997-10-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00