Abstract:
:The tumor suppressor protein p53 is one of the most important manipulators of the cell cycle. By interaction with targets such as WAF1/CIP1, mdm2 or GADD45 p53 functions as a negative or positive regulator of the cell cycle. After DNA damage p53 is implicated in growth arrest of cells in the G(1) phase of the cell cycle and in DNA repair and therefore p53 is regarded as a 'guardian of the genome'. Besides this protective role p53 participates in processes where cells are driven into programmed cell death. This controlled process called apoptosis is composed of a cascade of events which are dominantly influenced by p53. p53 plays a role in the initiation of cell suicide, directly or by interaction with cellular targets. A possible clinical implication of apoptosis and the implication of p53 in this process will be discussed.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Gotz C,Montenarh Mdoi
10.3892/ijo.6.5.1129subject
Has Abstractpub_date
1995-05-01 00:00:00pages
1129-35issue
5eissn
1019-6439issn
1791-2423journal_volume
6pub_type
杂志文章abstract::Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia (APL) through induction of apoptosis. To investigate the potential therapeutic usage of As2O3 in cervical cancer and its possible mechanisms, human cervical cancer cell line HeLa was employed. The cells underwent apopt...
journal_title:International journal of oncology
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更新日期:2002-07-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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更新日期:2014-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2003-05-01 00:00:00
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更新日期:2016-03-01 00:00:00
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更新日期:1994-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.695
更新日期:1993-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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更新日期:1999-08-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:2000-04-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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更新日期:2017-10-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2003-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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