Resveratrol suppresses growth of Ishikawa cells through down-regulation of EGF.

abstract：:Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, is very closely associated with telomerase activity. Telomerase has been implicated in cellular immortalization and carcinogenesis. In situ detection of hTERT will aid in determining the localization of telomerase-positive cells. The ...

journal_title：International journal of oncology

authors： Kammori M,Izumiyama N,Hashimoto M,Nakamura K,Okano T,Kurabayashi R,Naoki H,Honma N,Ogawa T,Kaminishi M,Takubo K

更新日期：2005-11-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis of all malignancies, and current therapeutic options do not target cancer stem cells (CSCs), which may be the reason for the extreme aggressiveness. The dietary agents sulforaphane and quercetin enriched e.g., in broccoli, and the main and best studied gre...

journal_title：International journal of oncology

authors： Appari M,Babu KR,Kaczorowski A,Gross W,Herr I

更新日期：2014-10-01 00:00:00

abstract：:We have utilized a series of glioma cell lines to study the effects of ionizing radiation on the regulation of proteins that contribute to cell cycle progression. While no alterations of cyclin E or cdk4 were detected, a high percentage of glioma cell lines exhibited constitutive overexpression of cdk2 protein and abe...

journal_title：International journal of oncology

authors： Pykett M,Azzam E,Little J

更新日期：1997-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training c...

journal_title：International journal of oncology

authors： Wang X,Liao X,Yu T,Gong Y,Zhang L,Huang J,Yang C,Han C,Yu L,Zhu G,Qin W,Liu Z,Zhou X,Liu J,Han Q,Peng T

更新日期：2019-10-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising anti-cancer agents, but some tumor types develop resistance to TRAIL. Here, we report that chetomin, an inhibitor of hypoxia-inducible factors, is a potent enhancer of TRAIL-induced apoptosis. TRAIL or chetomin alone weakly in...

journal_title：International journal of oncology

authors： Yano K,Horinaka M,Yoshida T,Yasuda T,Taniguchi H,Goda AE,Wakada M,Yoshikawa S,Nakamura T,Kawauchi A,Miki T,Sakai T

更新日期：2011-02-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs), are characterized by mutations of the KIT or platelet-derived growth factor receptor-α gene and the constitutive expression of Kit, which is currently being studied as a potential therapeutic target. In this study, we addressed the question of whether the microRNA (miRNA) 221/2...

journal_title：International journal of oncology

authors： Koelz M,Lense J,Wrba F,Scheffler M,Dienes HP,Odenthal M

更新日期：2011-02-01 00:00:00

abstract：:Accumulating evidence indicates that microRNAs (miRNAs) have a critical role in cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, the effect of miR‑300 on the development and progression of HCC remains unclear. In the present study, it was observed that miRNA (miR)‑300 expression was signif...

journal_title：International journal of oncology

authors： Chen Y,Guo Y,Li Y,Yang J,Liu J,Wu Q,Wang R

更新日期：2019-04-01 00:00:00

abstract：:Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E...

journal_title：International journal of oncology

authors： Vizirianakis IS,Chen YQ,Kantak SS,Tsiftsoglou AS,Kramer RH

更新日期：2002-07-01 00:00:00

abstract：:Since the efficacy of chemotherapy can be enhanced by targeting to specific receptors on tumors, we investigated the expression of LH-RH receptors in 5 human colon cancer lines and the effects of cytotoxic LH-RH analogs on these tumors. Nude mice bearing HT-29, HCT-116, HCT-15, LoVo and Colo-320DM cancers were treated...

journal_title：International journal of oncology

authors： Szepeshazi K,Schally AV,Halmos G

更新日期：2007-06-01 00:00:00

abstract：:Neuroblastoma shows complex patterns of genetic aberrations including MYCN amplification, deletion of chromosome 1p or 11q, and gain of chromosome 17q. The 17q gain is frequently observed in high-risk neuroblastomas, however, the candidate genes still remain elusive. In the present study, we integrated the data of com...

journal_title：International journal of oncology

authors： Yu M,Ohira M,Li Y,Niizuma H,Oo ML,Zhu Y,Ozaki T,Isogai E,Nakamura Y,Koda T,Oba S,Yu B,Nakagawara A

更新日期：2009-04-01 00:00:00

abstract：:Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vecto...

journal_title：International journal of oncology

authors： Yamanaka R

更新日期：2004-04-01 00:00:00

abstract：:Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...

journal_title：International journal of oncology

authors： Leung H,Hughes C,Kloppel G,Williamson R,Lemoine N

更新日期：1994-06-01 00:00:00

abstract：:We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...

journal_title：International journal of oncology

authors： Takahara Y,Yogosawa S,Maruyama S,Watanabe N,Yokoyama H,Fukasawa K,Sukenaga Y,Kamiyama J,Izumi M,Wakada M,Zhang H,Yoshizawa K,Kawa S,Nikaido T,Sakai T

更新日期：2006-04-01 00:00:00

abstract：:Meningiomas are the most commonly occurring intracranial tumors and account for approximately 15-20% of central nervous system tumors. Patients whose tumors recur after surgery and radiation therapy have limited therapeutic options. It has also been reported recently that radiation triggers DNA repair, cell survival a...

journal_title：International journal of oncology

authors： Gupta R,Rao Gogineni V,Nalla AK,Chetty C,Klopfenstein JD,Tsung AJ,Mohanam S,Rao JS

更新日期：2011-04-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00

abstract：:The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy woul...

journal_title：International journal of oncology

authors： Pang Y,Liu J,Li X,Zhang Y,Zhang B,Zhang J,Du N,Xu C,Liang R,Ren H,Tang SC,Sun X

更新日期：2017-10-01 00:00:00

abstract：:Established human breast cancer cell lines are widely used as experimental models in breast cancer research. While these cell lines and their variants share many phenotypic characteristics with human breast tumors, the extent to which they reflect the underlying molecular biology of breast cancer remains controversial...

journal_title：International journal of oncology

authors： Zhu Y,Wang A,Liu MC,Zwart A,Lee RY,Gallagher A,Wang Y,Miller WR,Dixon JM,Clarke R

更新日期：2006-12-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common solid neoplasm of adult kidney, and the major treatment for metastatic RCC (mRCC) is molecular targeted therapy. Sorafenib, as a multi-targeted tyrosine kinase inhibitor (TKI), has significantly improved clinical outcomes of mRCC patients. However, complete or long-term re...

journal_title：International journal of oncology

authors： Zhang P,Xing Z,Li X,Song Y,Zhao J,Xiao Y,Xing Y

更新日期：2016-04-01 00:00:00

abstract：:Primary intracerebral lymphoma is an uncommon presenting site for non-Hodgkin's lymphoma. The authors review 28 histopathologically confirmed, consecutive cases, presenting over a 15-year period. The cohort included 20 males and 8 females with a mean age at diagnosis of 54 years (range 27-75 years). Subtotal resection...

journal_title：International journal of oncology

authors： Hough RE,Smith CM,Nakielny RA,Robinson MH,Jacubowski J,Lorigan PC,Hancock BW

更新日期：1999-04-01 00:00:00

abstract：:Tumor cell (TC) metastasis is initiated by selective adhesion of TCs to target structures such as basement membrane and endotheliaI cells (ECs), followed by transvascular migration of TCs. Variants of murine B16 melanoma having different metastatic potentials (in the order BL6 greater than or equal to F10>F1>WA4) have...

journal_title：International journal of oncology

authors： Otsuji E,Park Y,Tashiro K,Kojima N,Toyokuni T,Hakomori S

更新日期：1995-02-01 00:00:00

abstract：:The hematogenous metastasis of cancer consists of a multistep process. It is surmised that a number of interactions between cancer and endothelial cells occur, with cell adhesion molecules playing certain roles in this process. The authors conducted an investigation on the interaction between human cancer cells and cu...

journal_title：International journal of oncology

authors： Sato M,Narita T,Kimura N,Nakashio T,Hashimoto T,Manabe T,Kannagi R

更新日期：1997-06-01 00:00:00

abstract：:NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...

journal_title：International journal of oncology

authors： Maruyama K,Tsukada T,Ohkura N,Bandoh S,Hosono T,Yamaguchi K

更新日期：1998-06-01 00:00:00

abstract：:Trophoblasts are derived from the normal placenta, and they infiltrate into the endometrium and the maternal blood vessels under strict control but, unlike malignant cells, never metastasize. To understand the proliferative characteristics of trophoblasts and its related disorders, we assessed telomerase activity in c...

journal_title：International journal of oncology

authors： Nishi H,Yahata N,Ohyashiki K,Isaka K,Shiraishi K,Ohyashiki JH,Toyama K,Takayama M

更新日期：1998-01-01 00:00:00

abstract：:Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the contribution of endogenous CCK to tumor growth is unknown. The purpose of this study was to evaluate the role of endogenous CCK on autocrine growth of pancreatic cancer...

journal_title：International journal of oncology

authors： Matters GL,McGovern C,Harms JF,Markovic K,Anson K,Jayakumar C,Martenis M,Awad C,Smith JP

更新日期：2011-03-01 00:00:00

abstract：:The interactions between cells and the extracellular matrix (EM) have important effects on tumor invasion and metastasis. Osteosarcoma (OS) is a highly metastatic tumor, secondary lesions occurring early in the natural history of the disease. Despite the clinical relevance of disseminated disease in this neoplasia, th...

journal_title：International journal of oncology

authors： Scotlandi K,Serra M,Manara M,Nanni P,Nicoletti G,Landuzzi L,Maurici D,Baldini N

更新日期：1993-11-01 00:00:00

abstract：:Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...

journal_title：International journal of oncology

authors： Tennstedt P,Köster P,Brüchmann A,Mirlacher M,Haese A,Steuber T,Sauter G,Huland H,Graefen M,Schlomm T,Minner S,Simon R

更新日期：2012-01-01 00:00:00

abstract：:Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. However, the effects of SAL on metastatic capacity of HT1080 human fibrosarcoma cells have not been elucidated. We investigated the effect of SAL on migration an...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2016-06-01 00:00:00

abstract：:In a retrospective analysis of 91 consecutive oral carcinomas we reviewed all patient records and weighed clinicopathological parameters against the results of image DNA cytometry and p53 immunhistochemical staining of the initial diagnostic biopsies. Eighty-seven percent of the biopsies were either aneuploid or nondi...

journal_title：International journal of oncology

authors： Hogmo A,Munckwikland E,Kuylenstierna R,Lindholm J,Auer G

更新日期：1994-10-01 00:00:00

abstract：:KRAS‑mutant colorectal cancer (CRC) is a highly malignant cancer with a poor prognosis, however specific therapies targeting KRAS mutations do not yet exist. Anti‑epidermal growth factor receptor (EGFR) agents, including cetuximab and panitumumab, are effective for the treatment of certain patients with CRC. However, ...

journal_title：International journal of oncology

authors： Koyama M,Kitazawa M,Nakamura S,Matsumura T,Miyazaki S,Miyagawa Y,Muranaka F,Tokumaru S,Okumura M,Yamamoto Y,Ehara T,Hondo N,Takahata S,Takeoka M,Miyagawa SI,Soejima Y

更新日期：2020-11-01 00:00:00

abstract：:Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....

journal_title：International journal of oncology

authors： Liu T,Mendes DE,Berkman CE

更新日期：2014-03-01 00:00:00