Nuclear-DNA content and p53 immunostaining in oral squamous-cell carcinoma - an analysis of a consecutive 10-year material.

abstract：:Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...

journal_title：International journal of oncology

authors： Fritz G,Issinger OG,Olsen BB

更新日期：2009-11-01 00:00:00

abstract：:177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...

journal_title：International journal of oncology

authors： Lundsten S,Spiegelberg D,Stenerlöw B,Nestor M

更新日期：2019-12-01 00:00:00

abstract：:UNC5A is an axon-guidance molecule, and plays a critical role in neuronal development and differentiation as a netrin-1 receptor. Emerging evidence suggests that axon guidance molecules including UNC5A regulate apoptosis in non-neuronal cells. Here, we report that UNC5A regulates apoptosis as a downstream target of p5...

journal_title：International journal of oncology

authors： Miyamoto Y,Futamura M,Kitamura N,Nakamura Y,Baba H,Arakawa H

更新日期：2010-05-01 00:00:00

abstract：:We studied the expresssion of estrogen (ER), progesterone (PgR), and androgen receptors (AR) in hepatocellular carcinoma (HCC) and found expression in (7/36), 3.2% (1/31), 16.7% (4/24) of cases, respectively. The expression of ER did not correlate with histological grade, tumor size, or stage of disease. On the other ...

journal_title：International journal of oncology

authors： Ishizu H,Une Y,Gondo H,Kameda H,Uchino J

更新日期：1994-06-01 00:00:00

abstract：:Over-expression of p21Waf-1 was performed in 5 human glioma cell lines (U251MG, U87MG, T98G, NMC-G1, and KALS-1). p53 gene status was examined by PCR-SSCP and direct sequence method. The endogenous p21Waf-1 expression was evaluated by RT-PCR. Adenovirus-mediated over-expression of p21Waf-1 inhibited the proliferation ...

journal_title：International journal of oncology

authors： Terasaki M,Kato S,Sugita Y,Shigemori M,Morimatsu M

更新日期：1999-01-01 00:00:00

abstract：:There is emerging evidence for the prognostic role of various microRNA (miRNA) molecules in colon cancer. The aim of this study was therefore to compare the miRNA profiles in the primary tumor of patients with recurrent and non-recurrent colon cancer. The study population included 110 patients, 51 (46%) with stage I a...

journal_title：International journal of oncology

authors： Weissmann-Brenner A,Kushnir M,Lithwick Yanai G,Aharonov R,Gibori H,Purim O,Kundel Y,Morgenstern S,Halperin M,Niv Y,Brenner B

更新日期：2012-06-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstrated that recombinant REIC/Dkk-3 protein induced the differentiation of h...

journal_title：International journal of oncology

authors： Watanabe M,Kashiwakura Y,Huang P,Ochiai K,Futami J,Li SA,Takaoka M,Nasu Y,Sakaguchi M,Huh NH,Kumon H

更新日期：2009-03-01 00:00:00

abstract：:CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...

journal_title：International journal of oncology

authors： Sato K,Dang NH

更新日期：2003-03-01 00:00:00

abstract：:A monoclonal antibody (MSN-3) was raised using HEC-108 cells derived from poorly differentiated endometrial carcinoma as the immunogen. The immunoglobulin subclass of MSN-3 was IgGr1. The target antigen of MSN-3 was a protein with a molecular weight of 77 kDa, and it was shown to be localized in the cytoplasm. MSN-3 o...

journal_title：International journal of oncology

authors： Hasegawa K,Tsukazaki K,Kubushiro K,Kobayashi Y,Kobiki K,Udagawa Y,Nozawa S

更新日期：1997-10-01 00:00:00

abstract：:Polypyrimidine tract-binding protein 1 (PTBP1), a heterogeneous nuclear ribonucleoprotein, is a multi-functional RNA-binding protein. PTBP1 participates in a number of biological processes, including maintaining cell structure and motility, immunity, protein metabolism and the cell cycle. The present study aimed to in...

journal_title：International journal of oncology

authors： Shan H,Hou P,Zhang M,Li L,Pan Y,Chen F,Jiang T,Bai J,Zheng J

更新日期：2018-05-01 00:00:00

abstract：:Cowden's disease (CD) is an autosomal dominant disorder which confers a high susceptibility to diverse benign and malignant tumors. The PTEN (phosphatase and tensin homologue deleted in chromosome ten) gene has been identified as a tumor suppressor gene responsible for cancers of the endometrium, ovary, prostate, and ...

journal_title：International journal of oncology

authors： Kato N,Kimura K,Sugawara H,Aoyagi S,Ikeda T,Horii A

更新日期：2001-05-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated antigens (sTAA) of 66 kDa and 51 kDa could promote suppression of chemically-induced rat mammary tumorigenesis by the hormone-related anticancer drug tamoxifen and prevent the drug's toxic side-effects. Dimethylbenzanthracene (DMBA, 10 mg/rat, 3 administrations)...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2002-02-01 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine), a major bioactive compound of Cordyceps militaris, has many pharmacological actions, such as anti-inflammatory and anticancer activities. In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in L...

journal_title：International journal of oncology

authors： Jeong JW,Jin CY,Park C,Han MH,Kim GY,Moon SK,Kim CG,Jeong YK,Kim WJ,Lee JD,Choi YH

更新日期：2012-05-01 00:00:00

abstract：:We established new two protein-free culture subclones from murine well-characterized Ehrlich ascites carcinoma and P815 mastocytoma using intermittent protein-free culture performed previously for a protein-free subclone of fibrosarcoma (Gc-4 PF). The Ehrlich protein-free subclone (Ehrlich PF) grew much more slowly th...

journal_title：International journal of oncology

authors： Watanabe H,Chigira M

更新日期：1992-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...

journal_title：International journal of oncology

authors： Liu J,Zhai R,Zhao J,Kong F,Wang J,Jiang W,Xin Q,Xue X,Luan Y

更新日期：2018-05-01 00:00:00

abstract：:Hepatocellular carcinoma is the most frequent liver cancer and hepatitis B virus is included among the risk factors for the development of this type of neoplasia. Direct detection of this virus is difficult due to the lack of a simple tissue culture system for growing the virus. Amplification of HBV nucleic acid seque...

journal_title：International journal of oncology

authors： Haliassos A,Arvanitis D,Parliaras J,Spandidos D

更新日期：1992-07-01 00:00:00

abstract：:Selenium is considered to be one of the most promising micronutrients for cancer prevention and therapy, based on evidence from epidemiological studies, laboratory-based research and clinical trial intervention. There are ample reports of selenium methionine and sodium selenite's ability to induce apoptosis in various...

journal_title：International journal of oncology

authors： Rooprai HK,Kyriazis I,Nuttall RK,Edwards DR,Zicha D,Aubyn D,Davies D,Gullan R,Pilkington GJ

更新日期：2007-05-01 00:00:00

abstract：:A promising family of anticancer agents, the camptothecins, is noted for their ability to induce apoptosis specifically in malignant cells. However, a major obstacle for successful cancer treatment by these and other chemotherapeutic agents is the intrinsic or acquired resistance to drug treatment. Resistance to 9NC6,...

journal_title：International journal of oncology

authors： Chatterjee D,Goldman M,Braastad CD,Darnowski J,Wyche JH,Pantazis P,Goodglick L

更新日期：2004-08-01 00:00:00

abstract：:Loss of E-cadherin and catenin expression may be associated with distant and lymph node metastases in breast cancer. Heterogeneity of E-cadherin expression is associated with poor prognosis, suggesting that E-cadherin and catenins may serve as useful prognostic markers for invasive breast carcinoma. Reduction or loss ...

journal_title：International journal of oncology

authors： Yoshida R,Kimura N,Harada Y,Ohuchi N

更新日期：2001-03-01 00:00:00

abstract：:Breast cancer is the neoplasia with the highest incidence in women worldwide. Proteomics approaches have accelerated the discovery of diagnostic and prognostic biomarkers. Here, we compared the proteomic profiles of breast tumors versus non-tumoral tissues in order to identify modul...

journal_title：International journal of oncology

authors： Fonseca-Sánchez MA,Rodríguez Cuevas S,Mendoza-Hernández G,Bautista-Piña V,Arechaga Ocampo E,Hidalgo Miranda A,Quintanar Jurado V,Marchat LA,Alvarez-Sánchez E,Pérez Plasencia C,López-Camarillo C

更新日期：2012-08-01 00:00:00

abstract：:Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...

journal_title：International journal of oncology

authors： Tait L,Dawson P,Wolman S,Galea K,Miller F

更新日期：1996-08-01 00:00:00

abstract：:We have previously isolated a drug-resistant, [PC3(R)], variant of human prostate PC3 cell line, which showed significant resistance (>10-fold) to adriamycin. No known mechanisms of drug resistance were found; however, resistant cells expressed more bcl2, c-myc, and ms oncogenes compared to the sensitive cells. In thi...

journal_title：International journal of oncology

authors： Sinha B,Song K

更新日期：1997-10-01 00:00:00

abstract：:A camptothecin (CPT) formulation that can be easily administered, is less toxic, and has greater antitumor effect is needed. In this study, a water-soluble CPT derivative was obtained by direct coupling of CPT to poly(L-glutamic acid) (PG) through the C20(S)-hydroxyl group. CPT was released from the resulting conjugat...

journal_title：International journal of oncology

authors： Zou Y,Wu QP,Tansey W,Chow D,Hung MC,Charnsangavej C,Wallace S,Li C

更新日期：2001-02-01 00:00:00

abstract：:The p53-induced wig-1 gene encodes an unusual nuclear zinc finger protein with high sequence similarity between human, rat and mouse. Wig-1 belongs to a group of proteins with widely spaced zinc fingers that bind double stranded (ds) RNA. We show here that wig-1 is present in Gallus gallus (chicken), Silurana tropical...

journal_title：International journal of oncology

authors： Hellborg F,Wiman KG

更新日期：2004-06-01 00:00:00

abstract：:Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). Identification of methylated genes is necessary to improve our understanding of the pathogenesis of HCC and develop novel biomarkers and therapeutic targe...

journal_title：International journal of oncology

authors： Tanaka Y,Kanda M,Sugimoto H,Shimizu D,Sueoka S,Takami H,Ezaka K,Hashimoto R,Okamura Y,Iwata N,Tanaka C,Yamada S,Fujii T,Nakayama G,Koike M,Nomoto S,Fujiwara M,Kodera Y

更新日期：2015-01-01 00:00:00

abstract：:Recent studies demonstrated an epigenetic inactivation of the runt-related transcription factor 3 (RUNX3) gene in human colon cancer. However, it remains unclear whether RUNX3 is tumor suppressive in colon cancer and, if so, the underlying molecular mechanisms of this activity are still unknown. In the present study, ...

journal_title：International journal of oncology

authors： Peng Z,Tang H,Wang X,Zhou C,Fan J,Wang L,Jia Z,Li Q,Le X,Wei D,Xie K

更新日期：2008-11-01 00:00:00

abstract：:To evaluate the significance of microsatellite instability (MI) and loss of heterozygosity (LOH) in the development of different histological subgroups of liposarcomas, we examined 28 tissue-samples from 21 patients and the corresponding non-neoplastic reference tissues. We investigated nine microsatellite loci and de...

journal_title：International journal of oncology

authors： Schneider-Stock R,Szibor R,Walter H,Plate I,Roessner A

更新日期：1999-04-01 00:00:00

abstract：:A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovar...

journal_title：International journal of oncology

authors： Yokomizo A,Tindall DJ,Hartmann L,Jenkins RB,Smith DI,Liu W

更新日期：1998-07-01 00:00:00

abstract：:The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...

journal_title：International journal of oncology

authors： Joly B,Lecureur V,Puozzo C,Guillouzo A,Fardel O

更新日期：1996-11-01 00:00:00