Abstract:
:To evaluate the significance of microsatellite instability (MI) and loss of heterozygosity (LOH) in the development of different histological subgroups of liposarcomas, we examined 28 tissue-samples from 21 patients and the corresponding non-neoplastic reference tissues. We investigated nine microsatellite loci and detected no MI. LOH for at least one marker was observed in 11 of 28 tumours (39%). Widespread allelic losses were a common characteristic of pleomorphic liposarcomas. Well-differentiated variants did not show LOH (p<0.003). Our findings support the idea that liposarcoma subgroups are defined by different spectra of genetic alterations. Inefficient DNA mismatch repair does not seem to be involved in the oncogenesis of liposarcomas.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Schneider-Stock R,Szibor R,Walter H,Plate I,Roessner Adoi
10.3892/ijo.14.4.721keywords:
subject
Has Abstractpub_date
1999-04-01 00:00:00pages
721-6issue
4eissn
1019-6439issn
1791-2423journal_volume
14pub_type
杂志文章abstract::Oncogenic drivers of osteosarcoma remain controversial due to the complexity of the genomic background of the disease. There are limited novel therapeutic options, and the survival rate of patients with osteosarcoma has not improved in decades. Genomic instability leads to complexity in various pathways, which is pote...
journal_title:International journal of oncology
pub_type: 杂志文章
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pub_type: 杂志文章,已发布勘误
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