Abstract:
:A serum-specific protein 'fingerprint' model was established which is capable of evaluating the effect of chemotherapy (gemcitabine) of pancreatic adenocarcinoma. We used SELDI-TOF-MS coupled with CM10 chips and bioinformatics tools to analyze a total of 45 mouse serum samples from three groups: the healthy control group, the pancreatic cancer model group (orthotopic transplantation model of human pancreatic adenocarcinoma) and the gemcitabine-treated group to establish diagnostic models. As a result, the test set yielded a specificity of 95.0% and a sensitivity of 95.0% for pattern 1, which distinguished pancreatic adenocarcinoma from healthy individuals and a specificity of 95.0% and a sensitivity of 75.0% for pattern 3, which distinguished healthy controls, PC model group and gemcitabine-treated group, as evaluated by leave-one-out cross-validation. We concluded from this study that the SELDI-TOF-MS technique combined with bioinformatics approaches can facilitate evaluating the effect of chemotherapy (gemcitabine) for pancreatic adenocarcinoma and could be used as a potential prognostic monitoring method.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Cao L,Wang L,Wang G,Liu D,Yu J,Que R,Xie Ddoi
10.3892/ijo_00000804subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1515-20issue
6eissn
1019-6439issn
1791-2423journal_volume
37pub_type
杂志文章abstract::177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4888
更新日期:2019-12-01 00:00:00
abstract::Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5140
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5040
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abstract::HeLa cell cultures were used as model systems for small interfering RNA (siRNA) induced knockdown of mRNA expression of the human telomerase catalytic subunit, telomerase reverse transcriptase (hTERT). Four 21-bp siRNAs targeting different sites of the hTERT mRNA were designed, and the siRNA molecules produced by a T7...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated tumor cells (DTCs) homing to the BM has yet to be defined. MicroRNAs (miRNA) play key roles in cellular...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1112
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abstract::Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1819
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abstract::We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.1.23
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-08-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis of all malignancies, and current therapeutic options do not target cancer stem cells (CSCs), which may be the reason for the extreme aggressiveness. The dietary agents sulforaphane and quercetin enriched e.g., in broccoli, and the main and best studied gre...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2539
更新日期:2014-10-01 00:00:00
abstract::Globally, breast cancer in women is the leading cause of cancer death. This fact has generated an interest to obtain insight into breast tumorigenesis and also to develop drugs to control the disease. Ras is a proto-oncogene that is activated as a response to extracellular signals. As a member of the Ras GTPase superf...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3298
更新日期:2016-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.6.1279
更新日期:1995-06-01 00:00:00
abstract::We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.6.1179
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abstract::We examined the optimal duration of whole body hyperthermia (WBH, 41.5 degrees C) when administered simultaneously with cis-diamminedichloroplatinum(II) (CDDP) using F344 rat fibrosarcoma model. The antitumor efficacy was measured by tumor growth delay (TGD) and nephrotoxicity was evaluated by the day 5 blood urea nit...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.2.329
更新日期:1997-02-01 00:00:00
abstract::The intensity of post-treatment melanoma patient follow-up varies widely among physicians. We investigated whether physician age accounts for the observed variation in surveillance intensity among plastic surgeons. A custom-designed questionnaire was mailed to USA and non-USA surgeons, all of whom were members of the ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.1.175
更新日期:2001-07-01 00:00:00
abstract::Telomerase activity and its subunits (hTERC, hTERT mRNA) were evaluated in ovarian tumours in relation to the expression of p53, c-Myc and estrogen receptor (ER). Furthermore, relations between telomerase activity, hTERC and hTERT with known clinicopathologic prognostic factors and survival in patients with malignant ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.23.5.1451
更新日期:2003-11-01 00:00:00
abstract::Ligands of the EGF/Heregulin family control the growth of epithelial cells by binding to receptors of the erbB family. By searching a large database of cDNA sequences at Human Genome Sciences Inc. we have identified a new encoded protein sequence containing all the conserved elements of the EGF/Heregulin family. The s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.5.1061
更新日期:1998-11-01 00:00:00
abstract::Effects of vorozole, a potent and specific non-steroidal aromatase inhibitor, were evaluated on female Sprague-Dawley (SD) rats with 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Vorozole at a dose of 0.25, 1.0 and 4.0 mg/kg was orally administered once a day for 28 consecutive days. A significant reg...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2021.5169
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pub_type: 杂志文章
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abstract::Hepatitis B X-interacting protein (HBXIP) is a novel oncoprotein. We have previously reported that HBXIP promotes the proliferation and migration of breast cancer cells. S-phase kinase-associated protein 2 (Skp2) is another oncoprotein which is important for migration. In this study, we investigated whether Skp2 is in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2411
更新日期:2014-07-01 00:00:00
abstract::We have previously shown that the combination of allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) using CD4+ cell-depleted spleen cells is effective in suppressing tumor growth, but that this does not induce graft-versus-host disease (GVHD) in mice. In this report,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::Metastasis is the main challenge of osteosarcoma treatment. Herein, we first reveal the oncogenic role of FAT10 in metastasis of osteosarcoma. FAT10 was upregulated in osteosarcoma, especially in metastatic osteosarcoma. High level of FAT10 was associated with poorer prognosis of osteosarcoma patients. Moreover, Trans...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3549
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abstract::Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant behavior of renal cell carcinoma in vitro and in vivo. eIF3C expression was ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
abstract::This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2005-10-01 00:00:00
abstract::A slowly proliferating cell fraction in tumors shows reduced sensitivity to cell cycle-dependent anticancer agents. To understand the molecular basis of drug resistance observed in brain tumors, we examined the relationship between alteration of p16, a cyclin dependent kinase inhibitor whose functions are frequently l...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.3.501
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abstract::The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1086
更新日期:2011-10-01 00:00:00
abstract::Models of animal melanoma are still indispensable tools in oncological research because they can be studied in syngeneic hosts while human melanomas cannot. One such model is a family of melanomas which originated in 1959 from a spontaneous melanotic melanoma of the skin in Syrian hamster, the Bomirski melanomas. Curr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.2.221
更新日期:1993-02-01 00:00:00
abstract::The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of our knowledge, there are only...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5098
更新日期:2020-09-01 00:00:00