Abstract:
:We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and carbohydrate antigen 19-9, as well as 7 serum proteins, including albumin and C-reactive protein. KMG-C showed more malignant biological behavior than an AFP-nonproducing GBC cell line, KMG-A, established originally from the tumor of the same patient; KMG-C had a shorter doubling time, higher tumorigenicity, and an aneuploid DNA index. Our results suggest that AFP-producing GBC cells may have more malignant biological characteristics than AFP-non-producing GBC cells in GBCs having both of these components.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Maruiwa M,Yano H,Fukuda K,Ogasawara S,Hisaka T,Yamaguchi R,Kojiro Mdoi
10.3892/ijo.8.6.1179subject
Has Abstractpub_date
1996-06-01 00:00:00pages
1179-88issue
6eissn
1019-6439issn
1791-2423journal_volume
8pub_type
杂志文章abstract::Angiogenesis plays a critical role in the development of solid tumors by supplying nutrients and oxygen to support continuous growth of tumor as well as providing an avenue for hematogenous metastasis. Tumor angiogenesis is highly regulated by multiple intracellular signaling transduction cascades such as Hedgehog, ST...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::A 60 year old man had two tumours resected from his liver which were shown histologically to be a well differentiated hepatocellular carcinoma and the fibrolamellar variant. Both are considered clinically distinct and of different pathogenesis and have not been previously reported occurring synchronously. DNA analysis...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:10.3892/ijo.2014.2350
更新日期:2014-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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更新日期:2015-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2511
更新日期:2014-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4125
更新日期:2017-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,收录出版
doi:10.3892/ijo.2011.1211
更新日期:2012-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1693
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000292
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journal_title:International journal of oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
更新日期:2004-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
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