Down-regulation of matrix-invasive potential of human liver cancer cells by type I interferon and a histone deacetylase inhibitor sodium butyrate.

abstract：:'Rare sugars' are defined as monosaccharides that exist in nature but are only present in limited quantities. The development of mass production method of rare sugars revealed some interesting physiological effects of these on animal cells, but the mechanisms have not been well studied. We examined the effect of D-all...

journal_title：International journal of oncology

authors： Yamaguchi F,Takata M,Kamitori K,Nonaka M,Dong Y,Sui L,Tokuda M

更新日期：2008-02-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphomas usually involve extranodal sites, especially the stomach, lung and salivary glands. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14) (p22;q32) in MALT lymphomas, and considered to be an apoptosis-associated gene, and involves a caspase recrui...

journal_title：International journal of oncology

authors： Ohshima K,Muta H,Kawasaki C,Muta K,Deyev V,Kanda M,Kumano Y,Podack ER,Kikuchi M

更新日期：2001-08-01 00:00:00

abstract：:A group of 133 primary oral squamous cell carcinomas were studied concerning a relationship between exposure factors and tumour biological parameters with a focus on the TP53 gene and p53 protein status. Tumours were evaluated using immunohistochemistry (IHC) for expression of p53, PCNA, Ki-67 and bcl-2 proteins. The ...

journal_title：International journal of oncology

authors： Schildt EB,Nylander K,Eriksson M,Hardell L,Magnusson A,Roos G

更新日期：2003-04-01 00:00:00

abstract：:Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...

journal_title：International journal of oncology

authors： Sartippour MR,Heber D,Zhang L,Beatty P,Elashoff D,Elashoff R,Go VL,Brooks MN

更新日期：2002-09-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) seems to have a pivotal role in maintaining the normal phenotype by suppressing cell growth through blocking the entrance of quiescent cells into the cell cycle. MnSOD protein expression has been shown to be dysregulated in malignant cells. A well-established experimental breast ...

journal_title：International journal of oncology

authors： Echiburú-Chau C,Roy D,Calaf GM

更新日期：2011-06-01 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via a specific mechanism. The aim of the present study was to clarify the mechanism of RHL by investigating its effect on mitochondrial damage and cell apoptosis. The results indicated that RHL inhibited cell growth an...

journal_title：International journal of oncology

authors： Liu J,Zhen YZ,Cui J,Hu G,Wei J,Xu R,Tu P,Lin YJ

更新日期：2018-11-01 00:00:00

abstract：:Mechanisms leading to inhibitory effects of an anti-GD2 ganglioside (GD2) 14G2a mouse monoclonal antibody (mAb) and PI3K/Akt/mTOR pathway inhibitors on human neuroblastoma cell survival were studied in vitro. We have recently shown on IMR-32, CHP‑134, and LA-N-1 neuroblastoma cells that targeting GD2 with the mAb decr...

journal_title：International journal of oncology

authors： Durbas M,Horwacik I,Boratyn E,Kamycka E,Rokita H

更新日期：2015-09-01 00:00:00

abstract：:In an attempt to isolate potential molecular targets for diagnosis, treatment and/or prevention of colorectal cancer (CRC), we have been analyzing expression profiles of clinical samples from CRC patients using genome-wide cDNA microarray. Among the genes up-regulated frequently in colorectal tumors, we here focused o...

journal_title：International journal of oncology

authors： Shimokawa T,Matsushima S,Tsunoda T,Tahara H,Nakamura Y,Furukawa Y

更新日期：2006-08-01 00:00:00

abstract：:The aim was to compare the efficacy of ondansetron and a combination of ondansetron plus dexamethasone in the prophylaxis of cisplatin-induced delayed emesis over three consecutive courses of chemotherapy. Cancer patients scheduled to receive for the first time cisplatin (>50 mg/m(2)) in combination with other cytotox...

journal_title：International journal of oncology

authors： Gridelli C,Ianniello G,Ambrosini G,Mustacchi G,Pedicini T,Farris A,Iacobelli S,Rossi G,Moretti G,Angelini F,Delena M,Dicarlo A,Bonsignori M,Sabbatini R,Catalano G,Rossi A,Olivieri A,Fina P,Bianco A

更新日期：1997-02-01 00:00:00

abstract：:Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorub...

journal_title：International journal of oncology

authors： Mattern J,Volm M

更新日期：1992-11-01 00:00:00

abstract：:Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...

journal_title：International journal of oncology

authors： Tameda M,Sugimoto K,Shiraki K,Yamamoto N,Okamoto R,Usui M,Ito M,Takei Y,Nobori T,Kojima T,Suzuki H,Uchida M,Uchida K

更新日期：2014-08-01 00:00:00

abstract：:There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-κB. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been perform...

journal_title：International journal of oncology

authors： Huang J,Guo P,Ma D,Lin X,Fang Q,Wang J

更新日期：2016-07-01 00:00:00

abstract：:Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...

journal_title：International journal of oncology

authors： Gazitt Y,Lavia M,Erdos G

更新日期：1993-09-01 00:00:00

abstract：:Malignant gliomas are diffuse infiltrative growing tumors with a poor prognosis despite treatment with a combination of surgery, radiotherapy and chemotherapy. It has been shown recently that complete tumor resection improves the survival time significantly. Hypericin, a component of St. Johns Wort, is one of the most...

journal_title：International journal of oncology

authors： Noell S,Mayer D,Strauss WS,Tatagiba MS,Ritz R

更新日期：2011-05-01 00:00:00

abstract：:Modulation of gene expression through histone deacetylase (HDAC) inhibition is considered a possible therapeutic strategy in acute myeloid leukaemia (AML). In vitro effects and basal gene expression of structurally different HDAC inhibitors were examined. Primary human AML cells were derived from 59 consecutive patien...

journal_title：International journal of oncology

authors： Stapnes C,Ryningen A,Hatfield K,Øyan AM,Eide GE,Corbascio M,Kalland KH,Gjertsen BT,Bruserud Ø

更新日期：2007-12-01 00:00:00

abstract：:Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...

journal_title：International journal of oncology

authors： Hadisaputri YE,Miyazaki T,Yokobori T,Sohda M,Sakai M,Ozawa D,Hara K,Honjo H,Kumakura Y,Kuwano H

更新日期：2017-03-01 00:00:00

abstract：:Interleukin (IL)-4 and IL-10 have a wide variety of activities in the immune system. We re-evaluated the action of IL-4 and IL-10 on human blood monocytes, myeloid dendritic cell (DC1) precursors, using a serum-free culture system. Both IL-4 and IL-10 inhibited the survival of CD14+ monocytes supported by granulocyte-...

journal_title：International journal of oncology

authors： Miyashita H,Katayama N,Fujieda A,Shibasaki T,Yamamura K,Sugimoto Y,Miyata E,Ohishi K,Nishii K,Masuya M,Shiku H

更新日期：2005-03-01 00:00:00

abstract：:Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant behavior of renal cell carcinoma in vitro and in vivo. eIF3C expression was ...

journal_title：International journal of oncology

authors： Fan M,Wang K,Wei X,Yao H,Chen Z,He X

更新日期：2019-12-01 00:00:00

abstract：:The prognosis of patients carrying glottic squamous cell carcinomas (GSCCs) involving the anterior commissure is often unpredictable. In order to assess the possible prognostic role of new and reliable parameters, p53 and cyclin D1 protein expression was immunohistochemically analysed in pathological samples from 27 p...

journal_title：International journal of oncology

authors： Pignataro L,Capaccio P,Pruneri G,Carboni N,Fracchiolla N,Richelda R,Scaramellini G,Neri A,Buffa R

更新日期：1996-09-01 00:00:00

abstract：:We previously reported that podophyllotoxin acetate (PA) radiosensitizes NCI-H460 cells. Here, we confirmed that PA treatment also induces cell death among two other non-small cell lung cancer (NSCLC) cell lines: NCI-H1299 and A549 cells (IC50 values = 7.6 and 16.1 nM, respectively). Our experiments further showed tha...

journal_title：International journal of oncology

authors： Choi JY,Hong WG,Cho JH,Kim EM,Kim J,Jung CH,Hwang SG,Um HD,Park JK

更新日期：2015-10-01 00:00:00

abstract：:Orlistat is an orally administered anti-obesity drug that has shown significant antitumor activity in a variety of tumor cells. To identify the proteins involved in its antitumor activity, we employed a proteomic approach to reveal protein expression changes in the human ovarian can...

journal_title：International journal of oncology

authors： Huang HQ,Tang J,Zhou ST,Yi T,Peng HL,Shen GB,Xie N,Huang K,Yang T,Wu JH,Huang CH,Wei YQ,Zhao X

更新日期：2012-08-01 00:00:00

abstract：:The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...

journal_title：International journal of oncology

authors： Wang Q,Hao J,Pu J,Zhao L,Lü Z,Hu J,Yu Q,Wang Y,Xie Y,Li G

更新日期：2011-10-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...

journal_title：International journal of oncology

authors： Collet N,Théoleyre S,Rageul J,Mottier S,Jouan F,Rioux-Leclercq N,Fergelot P,Patard JJ,Masson D,Denis MG

更新日期：2011-03-01 00:00:00

abstract：:Activation of intestinal human pregnane X receptor (PXR) has recently been proposed as a promising strategy for the chemoprevention of inflammation-induced colon cancer. The present study was aimed at evaluating the effect of rifaximin, a non-absorbable antibiotic, in inhibiting angiogenesis in a model of human colore...

journal_title：International journal of oncology

authors： Esposito G,Gigli S,Seguella L,Nobile N,D'Alessandro A,Pesce M,Capoccia E,Steardo L,Cirillo C,Cuomo R,Sarnelli G

更新日期：2016-08-01 00:00:00

abstract：:According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...

journal_title：International journal of oncology

authors： Furihata M,Sonobe H,Ohtsuki Y

更新日期：1995-06-01 00:00:00

abstract：:Knowledge of the presence and extent of disease plays a major role in clinical management of prostate cancer, as it provides meaningful information as to which therapy to choose and who might benefit from this therapy. The wide expression of androgen receptor (AR) in primary and metastatic prostate tumors offers a cel...

journal_title：International journal of oncology

authors： Yang J,Wu Z,Wu D,Darby MV,Hong SS,Miller DD,Dalton JT

更新日期：2010-01-01 00:00:00

abstract：:It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferati...

journal_title：International journal of oncology

authors： Zhang C,Xu W,Pan W,Wang N,Li G,Fan X,Xu X,Shen S,Das UN

更新日期：2013-05-01 00:00:00

abstract：:Mxi1 protein is a basic helix-loop-helix, leucine zipper (bHLHZIP) transcriptional factor, which dimerizes with the Max protein. This heterodimer binds a specific DNA sequence (E-box) and suppresses transcription of target genes. On the other hand, c-Myc protein is also a bHLHZIP protein that dimerizes with Max, binds...

journal_title：International journal of oncology

authors： Kawamata N,Sugimoto KJ,Sakajiri S,Oshimi K,Koeffler HP

更新日期：2005-05-01 00:00:00