Abstract:
:It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferation assays, immunochemical staining and immunoblotting and flow cytometry methods and in a xenograft model, we evaluated the role of SBP1 in proliferation, migration, senescence and chemoresistance of gastric cancer cells (SGC7901 and BGC823) to cisplatin. It was noted that diminished SBP1 expression increased gastric cancer cell proliferation and cell migration and decreased cisplatin-induced apoptosis while its overexpression produced the opposite effects. These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs. These results suggest that SBP1 can serve as a potential target to suppress gastric cancer.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Zhang C,Xu W,Pan W,Wang N,Li G,Fan X,Xu X,Shen S,Das UNdoi
10.3892/ijo.2013.1850subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1620-9issue
5eissn
1019-6439issn
1791-2423journal_volume
42pub_type
杂志文章abstract::Patients with pancreatic cancer frequently demonstrate symptoms such as weight-loss and muscle wasting and have clinical evidence of a systemic inflammatory response. Such effects may be mediated by pro-inflammatory cytokines derived from tumor cells. The production of interleukin-6 and -8 by pancreatic cancer cell li...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.21.4.881
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abstract::Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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abstract::NGFI-B, Nurr1 and NOR-1 have structural features of ligand-activated transcriptional regulators and constitute the NGFI-B subfamily within the nuclear receptor superfamily. Since specific ligands for these molecules have not yet been identified, they are often called orphan nuclear receptors. Genes of the NGFI-B subfa...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
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journal_title:International journal of oncology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3892/ijo.2017.3851
更新日期:2017-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.4.771
更新日期:2000-10-01 00:00:00
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2018.4283
更新日期:2018-04-01 00:00:00
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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abstract::Subsequent to the publication of the above article, the authors have realized that there were errors associated with Figs. 1c and 2b. In Fig. 1c, the authors noted that the same data were incorrectly presented for the 'Untreated cells" and 'DMSO' dot‑blot experiments. After having re‑examined their source data, the au...
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pub_type: 杂志文章,已发布勘误
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