Cytotoxic and cytostatic effects of polyphenols against rat 3y1 fibroblasts transformed by e1a gene of human adenovirus-type-12.

abstract：:Gene expression of dihydropyrimidine dehydrogenase (DPD) and newly multidrug resistance-associated protein (MRP) was found to correlate well with primary 5-FU resistance in 7 human gastrointestinal cancer cell lines. Although mRNA and protein levels of thymidylate synthase (TS) did not relate to the resistance, 5-FU t...

journal_title：International journal of oncology

authors： Kirihara Y,Yamamoto W,Toge T,Nishiyama M

更新日期：1999-03-01 00:00:00

abstract：:Thermal ablation of solid tumors using conductive interstitial thermal therapy (CITT) produces coagulative necrosis in the center of ablation. Local changes in homeostasis for surviving tumor and systemic changes in circulation and distant organs must be understood and monitored in order to prevent tumor re-growth and...

journal_title：International journal of oncology

authors： Przybyla BD,Shafirstein G,Vishal SJ,Dennis RA,Griffin RJ

更新日期：2014-02-01 00:00:00

abstract：:Resveratrol and other polyphenols have anti-carcinogenic and anti-tumorigenic activities in various carcinomas. However, such studies are limited in endometrial cancer. We hypothesize that resveratrol suppresses cancer growth through modulation of cell cycle and cell growth regulatory genes. To test this hypothesis, w...

journal_title：International journal of oncology

authors： Kaneuchi M,Sasaki M,Tanaka Y,Yamamoto R,Sakuragi N,Dahiya R

更新日期：2003-10-01 00:00:00

abstract：:Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...

journal_title：International journal of oncology

authors： Ratajczak-Wielgomas K,Grzegrzolka J,Piotrowska A,Matkowski R,Wojnar A,Rys J,Ugorski M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine proteases prevent DNA degradation and abrogate other signs of apoptosis in several cell systems (Gorczyca et al, Int J Oncol 1: ...

journal_title：International journal of oncology

authors： Gorczyca W,Ardelt B,Darzynkiewicz Z

更新日期：1993-10-01 00:00:00

abstract：:The regions upstream from the human N-myc gene were examined for both transcription and replication. The plasmids containing several N-myc regions linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to human neuroblastoma IMR32 cells. The results indicated that the region spanning fro...

journal_title：International journal of oncology

authors： Nakagawa T,Imamura Y,Iguchiariga S,Ariga H

更新日期：1994-09-01 00:00:00

abstract：:The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3, can induce differentiation in breast cancer cells; however, it is hypercalcemic in vivo. Therefore, development of non-calcemic analogs of vitamin D has received considerable attention. Recently, we synthesized an analog of vitamin D [1alpha(OH)D5] tha...

journal_title：International journal of oncology

authors： Mehta RR,Bratescu L,Graves JM,Green A,Mehta RG

更新日期：2000-01-01 00:00:00

abstract：:Human chondrosarcoma cells (HCS-TG) were transduced with the gene for a herpes simplex virus thymidine kinase (HSV-tk) or Escherichia coli beta-galactosidase (lacZ). We investigated the cytotoxicity of human chondrosarcoma bearing an HSV-tk gene after treatment with ganciclovir. Chondrosarcoma cells bearing an HSV-tk ...

journal_title：International journal of oncology

authors： Seto M,Wakabayashi H,Yamazaki T,Sonoda J,Shinto Y,Uchida A

更新日期：1999-06-01 00:00:00

abstract：:The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...

journal_title：International journal of oncology

authors： Gao Y,Li L,Li T,Ma L,Yuan M,Sun W,Cheng HL,Niu L,Du Z,Quan Z,Fan Y,Fan J,Luo C,Wu X

更新日期：2019-06-01 00:00:00

abstract：:The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

journal_title：International journal of oncology

authors： Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

更新日期：1997-03-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:The Equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, Herba epimedium brevicornum Maxim (stem and leaves), Radix morindae officinalis (root), Fructus rosa laevigatae michx (fruit), Rubus chingii Hu (fruit), Schisandra chinensis (Turz.) Baill (fruit), Ligustrum lucidum ...

journal_title：International journal of oncology

authors： Hsieh TC,Lu X,Guo J,Xiong W,Kunicki J,Darzynkiewicz Z,Wu JM

更新日期：2002-04-01 00:00:00

abstract：:Retinoids, which include vitamin A (retinol) and its derivatives, have previously been investigated as potential chemopreventive and chemotherapeutic agents in bladder cancer. We examined mRNA expression of the retinoid receptors RARalpha, RARbeta2, RARgamma and RXRalpha, as well as two putative RARbeta2 target genes,...

journal_title：International journal of oncology

authors： Boorjian S,Scherr DS,Mongan NP,Zhuang Y,Nanus DM,Gudas LJ

更新日期：2005-04-01 00:00:00

abstract：:Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...

journal_title：International journal of oncology

authors： Liu ZY,Qiu HO,Yuan XJ,Ni YY,Sun JJ,Jing W,Fan YZ

更新日期：2012-11-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have realized that Figs. 3 and 4 contained errors. Two sets of bands in Figs. 3D and 4B were erroneously placed during the process of figure preparation. In Fig. 3D, the β‑actin bands for the PANC‑1 and CFPAC‑1 cells were presented incorrectly, whereas in...

journal_title：International journal of oncology

authors： Ning Z,Wang A,Liang J,Xie Y,Liu J,Feng L,Yan Q,Wang Z

更新日期：2019-11-01 00:00:00

abstract：:Despite attempts to use multiple drug combinations that include gemcitabine (GEM), there is very little evidence that these combination regimens are superior to the single use of this agent. We therefore investigated the suppressive effect of the combination of systemically administered GEM and locally administered in...

journal_title：International journal of oncology

authors： Ito Y,Aiura K,Ueda M,Kitajima M,Kitagawa Y

更新日期：2008-07-01 00:00:00

abstract：:Gene therapy is a newly hatched field of biomedical research aimed at introducing therapeutically important genes into somatic cells of patients for the treatment of human disease. Whereas for inborn errors of metabolism transfer of a single gene can correct the disorder, cancer is a complex disease involving mutation...

journal_title：International journal of oncology

authors： Boulikas T

更新日期：1996-11-01 00:00:00

abstract：:Although a correlation between anaplasia and mutations of the p53 tumor suppressor gene has been found in Wilms' tumor (WT) a prognostic significance of p53 in WT remains largely unresolved. The goal of this study was to obtain a better understanding of the role of p53 expression in WT. Immunohistochemical analysis wa...

journal_title：International journal of oncology

authors： Beniers AJ,Efferth T,Füzesi L,Granzen B,Mertens R,Jakse G

更新日期：2001-01-01 00:00:00

abstract：:While the effects of single growth factors on endothelial cells (ECs) have been extensively studied, the importance of induction of growth factors such as PDGF-BB (platelet derived growth factor) in ECs and its impact on tumor cell functions are only partly understood. Human umbilical vein endothelial cells (HUVECs) w...

journal_title：International journal of oncology

authors： Reinmuth N,Rensinghoff S,Raedel M,Fehrmann N,Schwöppe C,Kessler T,Bisping G,Hilberg F,Roth GJ,Berdel W,Thomas M,Mesters RM

更新日期：2007-09-01 00:00:00

abstract：:In the multistep progressive pathogenesis of human breast cancer, comedo ductal carcinoma in situ (DCIS) represents a preinvasive precursor lesion for therapy resistant invasive cancer. Human tissue derived cell culture models exhibiting molecular similarities to clinical DCIS facilitate an important preclinical mecha...

journal_title：International journal of oncology

authors： Katdare M,Osborne M,Telang NT

更新日期：2002-10-01 00:00:00

abstract：:The tumor suppressor gene product p53 has been detected in a high percentage of esophageal squamous cell carcinoma. To evaluate the role of this protein in carcinogenesis, we examined the p53 overexpression both in esophageal dysplasia and in esophageal squamous cell carcinoma in the same patients. Using anti-p53 anti...

journal_title：International journal of oncology

authors： Maruyama K,Shiozaki H,Shimaya K,Inoue M,Iwazawa T,Matsui S,Mori T

更新日期：1994-05-01 00:00:00

abstract：:Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptio...

journal_title：International journal of oncology

authors： Alqahtani T,Kumarasamy VM,Huczyński A,Sun D

更新日期：2020-01-01 00:00:00

abstract：:The role and expression of ROCKI and ROCKII in human breast cancer was investigated and the effect on clinical outcome assessed. ROCK knockdown cells (MDA-MB-231DeltaROCKI and MDA-MB-231DeltaROCKII were tested for their in vitro invasiveness, motility and in vivo tumour growth. Samples of fresh frozen breast tumour ti...

journal_title：International journal of oncology

authors： Lane J,Martin TA,Watkins G,Mansel RE,Jiang WG

更新日期：2008-09-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC), the most common esophageal cancer in East Asia, is among the six cancers with the highest fatality rates worldwide. Unfortunately, multidisciplinary treatment strategies have not achieved satisfactory outcomes. Therefore, novel insights into the molecular biology of ESCC are ...

journal_title：International journal of oncology

authors： Tanaka H,Kanda M,Koike M,Iwata N,Shimizu D,Ezaka K,Sueoka S,Tanaka Y,Takami H,Hashimoto R,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Fujiwara M,Kodera Y

更新日期：2015-11-01 00:00:00

abstract：:The prognostic significance of Ki 67/MIB1 immunohistochemical assays (ICAs) was investigated in optimal technical conditions in 139 breast carcinomas. Automated ICAs (immunoperoxidase/Ventana device) was performed on frozen sections. Immunoprecipitates were quantified by computerized analysis (SAMBA) of digitized micr...

journal_title：International journal of oncology

authors： Charpin C,Garcia S,Bouvier C,Devictor B,Andra L,Lavaut M,Allasia C,Bonnier P

更新日期：1996-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of p53. Increasing evidence shows that miR-34a dysregulation may contribute to tumor development and progression in numerous cancers, includ...

journal_title：International journal of oncology

authors： Yang L,Song X,Zhu J,Li M,Ji Y,Wu F,Chen Y,Cui X,Hu J,Wang L,Cao Y,Wei Y,Zhang W,Li F

更新日期：2017-07-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...

journal_title：International journal of oncology

authors： Hossain MA,Kim DH,Jang JY,Kang YJ,Yoon JH,Moon JO,Chung HY,Kim GY,Choi YH,Copple BL,Kim ND

更新日期：2012-04-01 00:00:00

abstract：:The objective of these studies was to examine the murine pharmacokinetics, pharmacodynamics and metabolism of (3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone (Indole 15), a novel tubulin inhibitor for the treatment of cancer. We developed HPLC and LC/MS/MS assays to quantitate Indole 15 and characterize its metaboli...

journal_title：International journal of oncology

authors： Yang J,Ahn S,Wu Z,Hwang DJ,Miller DD,Dalton JT

更新日期：2012-07-01 00:00:00

abstract：:CD44 and CD133 mRNA expression as cancer stem cell markers in colorectal cancer were correlated with synchronous hepatic metastases and the clinicopathological factors, including patient survival. The CD44 and CD133 mRNA levels in 36 primary colorectal adenocarcinomas with synchronous hepatic metastasis were analyzed ...

journal_title：International journal of oncology

authors： Jing F,Kim HJ,Kim CH,Kim YJ,Lee JH,Kim HR

更新日期：2015-04-01 00:00:00

abstract：:Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...

journal_title：International journal of oncology

authors： Williams J,Maitland N,Mott M,Brown K

更新日期：1992-12-01 00:00:00