Abstract:
:Gene expression of dihydropyrimidine dehydrogenase (DPD) and newly multidrug resistance-associated protein (MRP) was found to correlate well with primary 5-FU resistance in 7 human gastrointestinal cancer cell lines. Although mRNA and protein levels of thymidylate synthase (TS) did not relate to the resistance, 5-FU treatment revealed a remarkable increase of TS expression. Such enhanced TS expression was more significant than DPD and MRP, and observed less in 5-FU sensitive cells. DPD and MRP expression levels can predict primary 5-FU resistance, and TS may be a potent predictor of cellular 5-FU resistance after 5-FU treatment.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Kirihara Y,Yamamoto W,Toge T,Nishiyama Mdoi
10.3892/ijo.14.3.551keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
551-6issue
3eissn
1019-6439issn
1791-2423journal_volume
14pub_type
杂志文章abstract::p57KIP2, the second class of KIP family protein, is one of the negative regulators of the cell cycle. To elucidate the role of p57KIP2 in colorectal normal mucosa and cancer, we examined the expression of p57KIP2 protein in 110 pairs of colorectal non-tumor and cancer tissues. Immunohistochemical analysis showed that ...
journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Genotoxic stress such as ionizing radiation can induce DNA damage and promote cell-cycle arrest or apoptosis through either a p53-dependent or -independent pathway. Recently, members of the FOXO Forkhead transcription factor family have been implicated in playing a role in both DNA repair and apoptosis in mammalian ce...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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abstract::The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...
journal_title:International journal of oncology
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abstract::Two mouse HPV16-transformed cell lines, viz. MK16 cells, which induce metastasizing tumors, and TC-1 cells, which induce non-metastasizing tumors were transduced with the gene for mouse endostatin. Two clones constitutively expressing endostatin were isolated from each of them. They were denoted ME3 and ME9, and TE2 a...
journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:International journal of oncology
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abstract::Following the publication of this article, the authors noted that there was an error in the affiliations. Specifically, the affiliation of the first author JUAN XU should be: Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China. [the original article was publis...
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pub_type: 杂志文章,已发布勘误
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更新日期:2017-06-01 00:00:00
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更新日期:2017-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
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doi:
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
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