Colonic prostaglandin-e2 in carcinogenesis in rats with N-methyl-n'-nitrosoguanidine.

abstract：:Induction of differentiation represents a promising concept for chemotherapy of malignant gliomas, which are often refractory even to the combined treatment with surgery, irradiation and chemotherapy. Since anti-neoplastic alkylphosphocholines can induce differentiation of leukemic cell lines, the effects of the intra...

journal_title：International journal of oncology

authors： Jendrossek V,Kugler W,Erdlenbruch B,Eibl H,Lakomek M

更新日期：2001-10-01 00:00:00

abstract：:We included in a case-control study on brain tumours and mobile and cordless telephones 1,617 patients aged 20-80 years of both sexes diagnosed during January 1, 1997 to June 30, 2000. They were alive at the study time and had histopathology verified brain tumour. One matched control to each case was selected from the...

journal_title：International journal of oncology

authors： Hardell L,Mild KH,Carlberg M

更新日期：2003-02-01 00:00:00

abstract：:The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid malignant tumors to alter the microenvironment represents an important characteristic through which tumor cells are able t...

journal_title：International journal of oncology

authors： Zhang X,Huang S,Guo J,Zhou L,You L,Zhang T,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:Tanshinone IIA (TSIIA), a natural diterpene quinone in the traditional Chinese medicinal herb Dan-Shen (Salvia miltiorrhiza), has extensively exerted antitumor activity in cellular and animal models. However, the molecular mechanisms underlying the antitumor effects of TSIIA remain largely unknown. The in vitro effect...

journal_title：International journal of oncology

authors： Zhang J,Wang J,Jiang JY,Liu SD,Fu K,Liu HY

更新日期：2014-08-01 00:00:00

abstract：:Human papillomavirus 16 (HPV-16) is strongly associated with the development of 50% of cervical cancers. The E6 and E7 proteins encoded by high-risk HPV types are associated with the immune evasion of cervical cancer cells, but the mechanism is poorly understood. The purpose of this study was to investigate whether ce...

journal_title：International journal of oncology

authors： Gao LJ,Gu PQ,Fan WM,Liu Z,Qiu F,Peng YZ,Guo XR

更新日期：2011-11-01 00:00:00

abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

journal_title：International journal of oncology

authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

更新日期：2006-01-01 00:00:00

abstract：:Although a correlation between anaplasia and mutations of the p53 tumor suppressor gene has been found in Wilms' tumor (WT) a prognostic significance of p53 in WT remains largely unresolved. The goal of this study was to obtain a better understanding of the role of p53 expression in WT. Immunohistochemical analysis wa...

journal_title：International journal of oncology

authors： Beniers AJ,Efferth T,Füzesi L,Granzen B,Mertens R,Jakse G

更新日期：2001-01-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:Elderly patients with advanced non-small cell lung cancer (NSCLC) require chemotherapy that is effective and minimally toxic. We evaluated the activity of a combination of vinorelbine and 5-fluorouracil (5-FU)/UFT (a fixed combination of tegafur and uracil) in vitro and in vivo to establish a rationale for clinical us...

journal_title：International journal of oncology

authors： Matsumoto S,Igishi T,Hashimoto K,Kodani M,Shigeoka Y,Nakanishi H,Touge H,Kurai J,Makino H,Takeda K,Yasuda K,Hitsuda Y,Shimizu E

更新日期：2004-11-01 00:00:00

abstract：:In solid tumours, necrosis is commonly found in the core region in response to metabolic stress that results from oxygen and glucose depletion (OGD) due to insufficient vascularization and has been implicated in tumour progression. We have previously shown that metabolic stress due to glucose depletion (GD) induces ne...

journal_title：International journal of oncology

authors： Kim CH,Ko AR,Lee SY,Jeon HM,Kim SM,Park HG,Han SI,Kang HS

更新日期：2010-01-01 00:00:00

abstract：:Natural antisense transcripts (NATs) constitute a class of non-coding RNAs that have emerged as important regulators of gene expression. However, involvement of NATs in colorectal cancer (CRC) development has not been reported to date. In the present study, the up- and down-regulation of NATs were investigated in huma...

journal_title：International journal of oncology

authors： Kohno K,Chiba M,Murata S,Pak S,Nagai K,Yamamoto M,Yanagisawa K,Kobayashi A,Yasue H,Ohkohchi N

更新日期：2010-12-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00

abstract：:A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovar...

journal_title：International journal of oncology

authors： Yokomizo A,Tindall DJ,Hartmann L,Jenkins RB,Smith DI,Liu W

更新日期：1998-07-01 00:00:00

abstract：:Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...

journal_title：International journal of oncology

authors： Hardell L,Fredrikson M,Axelson O

更新日期：1996-03-01 00:00:00

abstract：:High lactate production in cells during growth under oxygen-rich conditions (aerobic glycolysis) is a hallmark of tumor cells, indicating the role of mitochondrial function in tumorigenesis. In fact, enhanced mitochondrial biogenesis and impaired quality control are frequently observed in cancer cells. Mitochondrial D...

journal_title：International journal of oncology

authors： Jiménez-Morales S,Pérez-Amado CJ,Langley E,Hidalgo-Miranda A

更新日期：2018-09-01 00:00:00

abstract：:Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety of substrates; thus a...

journal_title：International journal of oncology

authors： Vafa A,Zhang Y,Sikes RA,Marengo SR

更新日期：1998-12-01 00:00:00

abstract：:Prostate cancer is initially sensitive to hormone therapy; however, over time the majority of patients progress to a hormone-insensitive form classified as castration-resistant prostate cancer (CRPC). CRPC is highly metastatic and patients have a poor prognosis. Thus, new drugs for the treatment of this disease are re...

journal_title：International journal of oncology

authors： Chen S,Nimick M,Cridge AG,Hawkins BC,Rosengren RJ

更新日期：2018-02-01 00:00:00

abstract：:177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...

journal_title：International journal of oncology

authors： Lundsten S,Spiegelberg D,Stenerlöw B,Nestor M

更新日期：2019-12-01 00:00:00

abstract：:Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of CDC20 in hepatocellular carc...

journal_title：International journal of oncology

authors： Li J,Gao JZ,Du JL,Huang ZX,Wei LX

更新日期：2014-10-01 00:00:00

abstract：:Many genes that are frequently mutated in human cancer are known to be involved in the control of normal cellular proliferation. One of the genes involved in DNA mismatch repair is hMLH1, defective mutations of which are found in some familial and various sporadic cancers. Although the DNA mismatch repair activity of ...

journal_title：International journal of oncology

authors： Shin KH,Han HJ,Park JG

更新日期：1998-03-01 00:00:00

abstract：:Although peritoneal lavage with distilled water performed after surgery prevents peritoneal seeding, cancer cells may avoid rupture under mild hypotonicity through regulatory volume decrease (RVD), which is the homeostatic regulation of ion and water transport. The aim of the present study was to investigate the effec...

journal_title：International journal of oncology

authors： Shiozaki A,Yamazato Y,Kosuga T,Kudou M,Shoda K,Arita T,Konishi H,Komatsu S,Kubota T,Fujiwara H,Okamoto K,Marunaka Y,Otsuji E

更新日期：2019-10-01 00:00:00

abstract：:Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an ou...

journal_title：International journal of oncology

authors： Casper J,Casper S,Kohnewompner C,Bokemeyer C,Hecker H,Schmoll H

更新日期：1994-06-01 00:00:00

abstract：:'Rare sugars' are defined as monosaccharides that exist in nature but are only present in limited quantities. The development of mass production method of rare sugars revealed some interesting physiological effects of these on animal cells, but the mechanisms have not been well studied. We examined the effect of D-all...

journal_title：International journal of oncology

authors： Yamaguchi F,Takata M,Kamitori K,Nonaka M,Dong Y,Sui L,Tokuda M

更新日期：2008-02-01 00:00:00

abstract：:Squamous cell carcinoma antigen (SCCA) is overexpressed in many squamous cell cancers and SCCA‑derived peptide-specific CD8(+) cytotoxic T lymphocytes can display cytotoxicity against tumor cells. In the present study, we screened the SCCA amino acid sequence for potential HLA-A*0201-binding CD8(+) T‑cell epitopes usi...

journal_title：International journal of oncology

authors： Duan ZL,Wang ZB,Guo JL,Liu WQ,Hu J,Li J,Wang SN,Li Q,Wen JS

更新日期：2013-04-01 00:00:00

abstract：:Low concentrations of monoclonal antibodies (mAb) specific for the CD3 component of the T cell receptor complex (TcR) may be both immunosuppressive or potent activators of T cell function in vitro depending upon the experimental situation. The anti-CD3 mAb OKT3 is imnmunosuppressive at high doses (5 mg/day for 10 to 1...

journal_title：International journal of oncology

authors： Hollingworth J,Catterick R,Horsburgh T,Veitch P,Bell P

更新日期：1994-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...

journal_title：International journal of oncology

authors： Liu J,Zhai R,Zhao J,Kong F,Wang J,Jiang W,Xin Q,Xue X,Luan Y

更新日期：2018-05-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:Recent studies have shown that chromosome 8p21-22 is the main site of frequent loss of heterozygosity (LOH) in breast cancers. However, the detailed molecular analysis of chromosome 8 so far in breast cancer has been variable. Most of the literature pertaining to LOH in breast cancer is mainly on short arm of chromoso...

journal_title：International journal of oncology

authors： Dahiya R,Perinchery G,Deng G,Lee C

更新日期：1998-04-01 00:00:00

abstract：:Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of hypericin aggregates present in the delivery vehicle on the biodistribution of the compound, we compared the in vivo tissue accumulation after administering hypericin...

journal_title：International journal of oncology

authors： Van De Putte M,Roskams T,Bormans G,Verbruggen A,De Witte PA

更新日期：2006-03-01 00:00:00