当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ONCOLOGY期刊下所有文献 > Effects of endostatin production on oncogenicity and metastatic activity of HPV16-transformed mouse cells: role of interleukin 1alpha.

Effects of endostatin production on oncogenicity and metastatic activity of HPV16-transformed mouse cells: role of interleukin 1alpha.

Abstract：

:Two mouse HPV16-transformed cell lines, viz. MK16 cells, which induce metastasizing tumors, and TC-1 cells, which induce non-metastasizing tumors were transduced with the gene for mouse endostatin. Two clones constitutively expressing endostatin were isolated from each of them. They were denoted ME3 and ME9, and TE2 and TE5, respectively. When inoculated into mice, ME3 cells were non-oncogenic. Nearly all mice inoculated with ME9 cells developed tumors, but considerably later than did the parental MK16 cells and metastasis formation was strongly reduced in these animals. On the other hand, TE2 and TE5 cells displayed oncogenic potential similar to that of the parental cells. To provide more information on these different effects of endostatin production, cell lysates of all six lines studied were tested for the content of 25 factors known to be involved in angiogenesis. The parental MK16 cells differed from the parental TC-1 cells and also from all endostatin producing sublines by a markedly higher production of interleukin 1alpha (IL-1alpha) and, to a lesser extent, by a higher production of several other factors tested. Additional experiments indicated that the suppression of the production of IL-1alpha by the parental MK16 caused by endostatin was due to an autocrine mechanism.

journal_name

Int J Oncol

journal_title

International journal of oncology

authors

Lakatosova-Andelova M,Duskova M,Lucansky V,Paral P,Vonka V

doi

10.3892/ijo_00000331

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

213-22

issue

1

eissn

1019-6439

issn

1791-2423

journal_volume

35

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ONCOLOGY文献大全
  • Downregulation of miR-374b-5p promotes chemotherapeutic resistance in pancreatic cancer by upregulating multiple anti-apoptotic proteins.

    abstract：:Resistance to first-line chemotherapeutic drugs such as gemcitabine contributes to the poor prognosis of patients with pancreatic cancer. MicroRNAs (miRNA) regulate chemoresistance in pancreatic cancer. By analyzing the miRNA sequencing dataset of pancreatic cancer from The Cancer Genome Atlas, it was demonstrated tha...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2018.4315

    authors： Sun D,Wang X,Sui G,Chen S,Yu M,Zhang P

    更新日期：2018-05-01 00:00:00

  • Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review).

    abstract：:The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signal...

    journal_title：International journal of oncology

    pub_type： 杂志文章,评审

    doi：10.3892/ijo.2011.1312

    authors： Hafsi S,Pezzino FM,Candido S,Ligresti G,Spandidos DA,Soua Z,McCubrey JA,Travali S,Libra M

    更新日期：2012-03-01 00:00:00

  • Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors.

    abstract：:We have examined six patients with multiple low grade, low stage superficial multifocal bladder tumors with surrounding tissues for loss of heterozygosity (LOH) and microsatellite instability at chromosome 3, totaling 76 samples. The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FH...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.18.1.203

    authors： Louhelainen J,Wijkström H,Hemminki K

    更新日期：2001-01-01 00:00:00

  • Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.

    abstract：:Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major rol...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo_00000411

    authors： Kawaguchi M,Banno K,Yanokura M,Kobayashi Y,Kishimi A,Ogawa S,Kisu I,Nomura H,Hirasawa A,Susumu N,Aoki D

    更新日期：2009-11-01 00:00:00

  • Galiximab (anti-CD80)-induced growth inhibition and prolongation of survival in vivo of B-NHL tumor xenografts and potentiation by the combination with fludarabine.

    abstract：:Galiximab is a primatized monoclonal antibody that targets CD80 expressed on malignant B cells and is being studied in the clinic as a potential treatment for follicular NHL. We have recently reported that galiximab signals B-NHL cells in vitro and inhibits cell growth and sensitizes resistant tumor cells to apoptosis...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2013.1986

    authors： Hariharan K,Chu P,Murphy T,Clanton D,Berquist L,Molina A,Ho SN,Vega MI,Bonavida B

    更新日期：2013-08-01 00:00:00

  • CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1.

    abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2019.4805

    authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

    更新日期：2019-07-01 00:00:00

  • COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS.

    abstract：:Colorectal cancer (CRC) treatment primarily relies on chemotherapy along with surgery, radiotherapy and, more recently, targeted therapy at the late stages. However, chemotherapeutic drugs have high cytotoxicity, and the similarity between the effects of these drugs on cancerous and healthy cells limits their wider us...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2018.4536

    authors： Zhang Z,Fang C,Wang Y,Zhang J,Yu J,Zhang Y,Wang X,Zhong J

    更新日期：2018-11-01 00:00:00

  • Increased mdm2 expression and immunoreactivity in human pancreatic ductal adenocarcinoma.

    abstract：:The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.5.6.1279

    authors： Ebert M,Yokoyama M,Kobrin M,Friess H,Buchler M,Korc M

    更新日期：1994-12-01 00:00:00

  • Retroviral-mediated expression of telomerase in normal human cells provides a selective growth advantage.

    abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

    更新日期：2002-06-01 00:00:00

  • Role of ras oncogene in adriamycin resistance in human prostate tumor cells.

    abstract：:We have previously isolated a drug-resistant, [PC3(R)], variant of human prostate PC3 cell line, which showed significant resistance (>10-fold) to adriamycin. No known mechanisms of drug resistance were found; however, resistant cells expressed more bcl2, c-myc, and ms oncogenes compared to the sensitive cells. In thi...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.11.4.819

    authors： Sinha B,Song K

    更新日期：1997-10-01 00:00:00

  • Regulation of cell-growth and apoptosis in synchronized agf cells - involvement of oncogenes and cell-cycle regulatory proteins.

    abstract：:Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Gazitt Y,Lavia M,Erdos G

    更新日期：1993-09-01 00:00:00

  • Up-regulation of Frizzled-7 (FZD7) in human gastric cancer.

    abstract：:Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Kirikoshi H,Sekihara H,Katoh M

    更新日期：2001-07-01 00:00:00

  • Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding.

    abstract：:Three novel isoforms of the neurofibromatosis 2 (NF2) gene transcripts generated from alternative splicing were identified from normal human brain, schwannoma and glioma tissues. The 3 novel transcripts lack exon 2, exons 2 and 3, exons 2-4, respectively. Recombinant isoform proteins encoded by those new transcripts h...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.10.5.1025

    authors： Nishi T,Takeshima H,Hamada K,Yoshizato K,Koga H,Sato K,Yamamoto K,Kitamura I,Kochi M,Kuratsu J,Saya H,Ushio Y

    更新日期：1997-05-01 00:00:00

  • Iodine‑131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma.

    abstract：:Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2020.4957

    authors： Brito AF,Abrantes AM,Teixo R,Pires AS,Ribeiro AC,Ferreira RF,Mascarenhas A,Puga T,Laranjo M,Caramelo F,Boin I,Jefferson DM,Gonçalves C,Martins R,Tavares I,Ribeiro IP,Sarmento-Ribeiro AB,Carreira IM,Souza D,Tralhão J

    更新日期：2020-03-01 00:00:00

  • Prostate cancer as an environmental disease: an ecological study in the French Caribbean islands, Martinique and Guadeloupe.

    abstract：:Using a transdisciplinary methodological approach we have conducted a multifactorial analysis in Martinique and Guadeloupe in order to elucidate the aetiology of prostate cancer. In 2002, world age standardized rates of prostate cancer were 152 new cases per 100,000 person-years in the two islands; one of the highest ...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo_00000229

    authors： Belpomme D,Irigaray P,Ossondo M,Vacque D,Martin M

    更新日期：2009-04-01 00:00:00

  • Resistance factors and proliferative activity in childhood acute nonlymphoblastic leukemia.

    abstract：:Thirty-four children with newly diagnosed acute nonlymphoblastic leukemia were analysed for the expression of P-glycoprotein (P-170), glutathione S-transferase-pi, (GST-pi) topoisomerase II (Topo II) and the proliferation antigen Ki-67 by the streptavidin-biotin-peroxidase method. Overexpression of P-170 was present i...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.5.4.841

    authors： Sauerbrey A,Zintl F,Volm M

    更新日期：1994-10-01 00:00:00

  • TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma.

    abstract：:Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2017.3869

    authors： Hadisaputri YE,Miyazaki T,Yokobori T,Sohda M,Sakai M,Ozawa D,Hara K,Honjo H,Kumakura Y,Kuwano H

    更新日期：2017-03-01 00:00:00

  • Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression.

    abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

    更新日期：2007-10-01 00:00:00

  • KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes.

    abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

    更新日期：2006-10-01 00:00:00

  • NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells.

    abstract：:Nitric oxide (NO) shows tumoricidal activity. We had previously reported that NO downregulates the phosphatidylinositol-3-kinase/Akt pathway, but upregulates the MEK/ERK pathway downstream of growth factor signaling. We hypothesized that NO donor and MEK inhibitor in combination syn...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2011.1243

    authors： Furuhashi S,Sugita H,Takamori H,Horino K,Nakahara O,Okabe H,Miyake K,Tanaka H,Beppu T,Baba H

    更新日期：2012-03-01 00:00:00

  • FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.

    abstract：:Family with sequence similarity 83 member A (FAM83A) has been recently observed to be upregulated in various types of cancer and hypothesized to be serve as an oncogene. The present study aimed to determine the functional roles and the underlying molecular mechanism of FAM83A in cervical cancer. The results demonstrat...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2020.5078

    authors： Xu J,Lu W

    更新日期：2020-08-01 00:00:00

  • Prevalent hyper-methylation of the CDH13 gene promoter in malignant B cell lymphomas.

    abstract：:CDH13 (H-cadherin) is a member of the cadherin superfamily, which plays an important role in cell recognition and adhesion. We examined the expression and methylation status of the CDH13 gene in diffuse large B cell lymphomas (B-DLCLs). We found decreased expression of the CDH13 gene in all of 6 hematopoietic cell lin...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Ogama Y,Ouchida M,Yoshino T,Ito S,Takimoto H,Shiote Y,Ishimaru F,Harada M,Tanimoto M,Shimizu K

    更新日期：2004-09-01 00:00:00

  • Tumor-necrosis-factor and DNA topoisomerase-ii inhibitors in human ovarian-cancer - potential role in chemotherapy.

    abstract：:Seven ovarian and one cervical human cancer cell lines were examined far their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and to...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Aluigi M,Debernardis D,Cimoli G,Ottoboni C,Parodi S,Russo P

    更新日期：1995-09-01 00:00:00

  • Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS(2)FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line.

    abstract：:We previously developed a new microscopic observation system that enables time-lapse quantitative analysis of apoptosis and necrosis. With this system we quantitatively analyzed adriamycin (ADR)-induced cell death using manganese superoxide dismutase (MnSOD)- and wild-type p53-gene transfectants on SaOS(2), a p53-defi...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Wang Y,Kuroda M,Gao XS,Asaumi J,Shibuya K,Kawasaki S,Akaki S,St Clair D,Hiraki Y,Kanazawa S

    更新日期：2005-05-01 00:00:00

  • Adenovirus E1A orchestrates the urokinase-plasminogen activator system and upregulates PAI-2 expression, supporting a tumor suppressor effect.

    abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

    更新日期：2006-01-01 00:00:00

  • Pyrogallol induces the death of human pulmonary fibroblast cells through ROS increase and GSH depletion.

    abstract：:Pyrogallol (PG) inhibits the growth of various cells via stimulating O2•--mediated death. This study investigated the effects of PG on cell death in human pulmonary fibroblast (HPF) cells in relation to reactive oxygen species (ROS) and glutathione (GSH) levels. PG inhibited the growth of HPF cells with an IC50 of ~50...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2016.3543

    authors： Park WH

    更新日期：2016-08-01 00:00:00

  • Immunotherapy for malignant tumors using combination of allogeneic intra-bone marrow-bone marrow transplantation, donor lymphocyte infusion and dendritic cells.

    abstract：:We have previously shown that the combination of allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) using CD4+ cell-depleted spleen cells is effective in suppressing tumor growth, but that this does not induce graft-versus-host disease (GVHD) in mice. In this report,...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Mukaide H,Adachi Y,Koike-Kiriyama N,Suzuki Y,Minamino K,Iwasaki M,Tsuda M,Nakano K,Koike Y,Shigematsu A,Kamiyama Y,Ikehara S

    更新日期：2007-06-01 00:00:00

  • Esculetin (6,7-dihydroxycoumarin): a potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells.

    abstract：:Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent. The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamo...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2014.2700

    authors： Cho JH,Shin JC,Cho JJ,Choi YH,Shim JH,Chae JI

    更新日期：2015-01-01 00:00:00

  • Correlation of the response of recurrent malignant gliomas treated with interferon alpha with tumor interferon alpha gene content.

    abstract：:Malignant gliomas are treated by combining surgery and radiation with chemotherapy. Cure is rare and utilizing information arising from our improved understanding of brain tumor biology may be of value. Interferon alpha (IFNalpha) treatment as restorative immunotherapy has been utilized in malignant gliomas in the pas...

    journal_title：International journal of oncology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Olson JJ,James CD,Lawson D,Hunter S,Tang G,Billingsley J

    更新日期：2004-08-01 00:00:00

  • Optimal duration of whole body hyperthermia when combined with cis-diamminedichloroplatinum(II).

    abstract：:We examined the optimal duration of whole body hyperthermia (WBH, 41.5 degrees C) when administered simultaneously with cis-diamminedichloroplatinum(II) (CDDP) using F344 rat fibrosarcoma model. The antitumor efficacy was measured by tumor growth delay (TGD) and nephrotoxicity was evaluated by the day 5 blood urea nit...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.10.2.329

    authors： Makino M,Ohno S,Sakaguchi Y,Kaneko T,Strebel F,Jenkins G,Bull J

    更新日期：1997-02-01 00:00:00