Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome.

abstract：:CXC chemokines have a major influence on the angiogenesis, growth and metastatic potential of pancreatic ductal adenocarcinoma. CXCL16 is a unique transmembrane CXC chemokine, which is shed by members of the disintegrins and metalloproteases (ADAMs), in particular by ADAM10 and ADAM17. In our study, we evaluated expre...

journal_title：International journal of oncology

authors： Wente MN,Gaida MM,Mayer C,Michalski CW,Haag N,Giese T,Felix K,Bergmann F,Giese NA,Friess H

更新日期：2008-08-01 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for human breast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, is a well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. I...

journal_title：International journal of oncology

authors： Huynh H,Beamer W,Pollak M,Chan TW

更新日期：2000-02-01 00:00:00

abstract：:The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia-induced growth arrest and apoptosis. The aim of this study was to analyze the overall effect of HIF-1 on tumor growth in a mouse model, em...

journal_title：International journal of oncology

authors： Savai R,Schermuly RT,Voswinckel R,Renigunta A,Reichmann B,Eul B,Grimminger F,Seeger W,Rose F,Hänze J

更新日期：2005-08-01 00:00:00

abstract：:We investigated three clonally related human keratinocyte cell lines of different biological behaviour, HaCaT (non-tumorigenic), A5 (benign, tumorigenic) and II-4RT (malignant, tumorigenic), with regard to the cell-associated localization of the major MMPs -1, -2, -3, -9, -10 and -11. These observations were correlate...

journal_title：International journal of oncology

authors： Bachmeier BE,Nerlich AG

更新日期：2002-03-01 00:00:00

abstract：:Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer cell lines. However, the anticancer activity and mechanisms of PM in prostate cancer cells have not been adequately investigated. Here we report that the degra...

journal_title：International journal of oncology

authors： Liu YB,Gao X,Deeb D,Brigolin C,Zhang Y,Shaw J,Pindolia K,Gautam SC

更新日期：2014-10-01 00:00:00

abstract：:Ovarian cancer is a lethal malignancy, rarely diagnosed early, and there is currently little, if any, preventive strategies which can be followed. This study attempts to identify lifestyle profiles which might be associated with ovarian cancer, and could then be subject to subsequent modification in an effort to preve...

journal_title：International journal of oncology

authors： Loesch M,Fischer M,Shurpin K,Mann W

更新日期：1994-03-01 00:00:00

abstract：:The over-expression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis. As LY-6K belongs to the Ly6/uPAR superfamily, we assessed the association of LY-6K with metastasis in breast cancer cell lines and how the LY-6K gene mediates cancer cell metastasis. The migrati...

journal_title：International journal of oncology

authors： Choi SH,Kong HK,Park SY,Park JH

更新日期：2009-09-01 00:00:00

abstract：:The treatment of glioblastoma is unsatisfactory. Improved understanding of the biological effects of treatment, together with development of new tools to predict outcome of the initiated treatment are therefore of great need. Vandetanib (ZD6474) is mainly a vascular endothelial growth factor (VEGF) and epidermal growt...

journal_title：International journal of oncology

authors： Wibom C,Sandström M,Henriksson R,Antti H,Johansson M,Bergenheim AT

更新日期：2010-10-01 00:00:00

abstract：:Following the publication of this article, an interested reader drew to our attention that Fig. 1C contained an important flaw. The Figure shows a western blot for LCN2, DR4, DR5, and actin, and it was noted that the identical bands shown for actin were also featured in a paper by the same authors published in 2017 [L...

journal_title：International journal of oncology

authors： Kim SL,Min IS,Park YR,Lee ST,Kim SW

更新日期：2019-05-01 00:00:00

abstract：:Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...

journal_title：International journal of oncology

authors： Konduri S,Lakka SS,Tasiou A,Yanamandra N,Gondi CS,Dinh DH,Olivero WC,Gujrati M,Rao JS

更新日期：2001-09-01 00:00:00

abstract：:PDZ-domain protein GIPC1/GIPC interacts with GTPase-activating protein RGS-GAIP, TGFbeta type III receptor, and integrin alpha6A subunit. Kermit, a Xenopus orthologue of human GIPC1, interacts with some class of WNT receptor. In this study, we identified a novel GIPC1-related gene in human genome by using bioinformati...

journal_title：International journal of oncology

authors： Kirikoshi H,Katoh M

更新日期：2002-03-01 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer related deaths in men in the United States. Ciprofloxacin is a relatively non-toxic antibiotic that can be easily administered orally with large volume of distribution and good tissue penetration. Studies from others and our l...

journal_title：International journal of oncology

authors： El-Rayes BF,Grignon R,Aslam N,Aranha O,Sarkar FH

更新日期：2002-07-01 00:00:00

abstract：:The incidence of thyroid cancer has increased in the past decades; however, the underlying molecular mechanisms of thyroid cancer tumorigenesis remain unknown. Using sequencing technology, long intergenic non‑protein coding RNA 673 (LINC00673) was identified to be upregulated in several tumor tissues. However, the bio...

journal_title：International journal of oncology

authors： Xia E,Bhandari A,Shen Y,Zhou X,Wang O

更新日期：2018-11-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by extensive angiogenesis that is mostly orchestrated by the hypoxia inducible factor HIF-1. Deregulation of HIF-1 is believed to contribute to cancer initiation and progression. However, instances have been described in which loss of HIF-1 leads to more aggressive tumors...

journal_title：International journal of oncology

authors： Fiorenzo P,Mongiardi MP,Dimitri D,Cozzolino M,Ferri A,Montano N,Trevisi G,Maira G,Battistini L,Falchetti ML,Levi A,Pallini R

更新日期：2010-04-01 00:00:00

abstract：:Chemotherapeutic treatment with combinations of drugs is front-line therapy for many types of cancer. Combining drugs that target different signaling pathways often lessens adverse side-effects while increasing the efficacy of treatment and reducing patient morbidity. Histone deacetylase (HDAC) inhibitors represent a ...

journal_title：International journal of oncology

authors： Sato T,Suzuki M,Sato Y,Echigo S,Rikiishi H

更新日期：2006-05-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00

abstract：:Clinical trials using antiangiogenic drugs revealed their potential against cancer. Unfortunately, a large percentage of patients does not yet benefit from this therapeutic approach highlighting the need of diagnostic tools to non-invasively evaluate and monitor response to therapy. It would also allow to predict whic...

journal_title：International journal of oncology

authors： Taurone S,Galli F,Signore A,Agostinelli E,Dierckx RA,Minni A,Pucci M,Artico M

更新日期：2016-08-01 00:00:00

abstract：:The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative ...

journal_title：International journal of oncology

authors： Bai XZ,Masters JR,O'Donoghue N,Kirby R,Pan LX,Young M,Stafford M,Parkinson MC

更新日期：1999-04-01 00:00:00

abstract：:Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent. The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamo...

journal_title：International journal of oncology

authors： Cho JH,Shin JC,Cho JJ,Choi YH,Shim JH,Chae JI

更新日期：2015-01-01 00:00:00

abstract：:Photodynamic therapy (PDT) following lung-sparing extended pleurectomy for malignant pleural mesothelioma (MPM) has been investigated as a potential means to kill residual microscopic cells. High expression levels of folate receptor 1 (FOLR1) have been reported in MPM; therefore, targeting FOLR1 has been considered a ...

journal_title：International journal of oncology

authors： Kato T,Jin CS,Lee D,Ujiie H,Fujino K,Hu HP,Wada H,Wu L,Chen J,Weersink RA,Kanno H,Hatanaka Y,Hatanaka KC,Kaga K,Matsui Y,Matsuno Y,De Perrot M,Wilson BC,Zheng G,Yasufuku K

更新日期：2018-11-01 00:00:00

abstract：:Three separate experiments, designed to minimize the DNA repair process following exposures to mutagens, were performed to determine whether DNA repair capability is the sole factor responsible for differential mutagen sensitivity. These experiments included (i) very short bleomycin pulse treatments (2, 5 and 10 min),...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Brock W,Liang J

更新日期：1995-01-01 00:00:00

abstract：:Meningiomas are benign brain tumors thought to arise by multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cell cycle regulator proto-oncogene cyclin D1 has been implicated in the pathogenesis of several types of cancer. Northern blot analysis revealed expr...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-12-01 00:00:00

abstract：:Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...

journal_title：International journal of oncology

authors： Lin C,Tsai SC,Tseng MT,Peng SF,Kuo SC,Lin MW,Hsu YM,Lee MR,Amagaya S,Huang WW,Wu TS,Yang JS

更新日期：2013-03-01 00:00:00

abstract：:This study defines the role of WWOX in the regulation of epithelial to mesenchymal transition. A group of 164 endometrial adenocarcinoma patients was studied as well as an ECC1 well-differentiated steroid-responsive endometrial cell line, which was transducted with WWOX cDNA by a retroviral system. The relationship be...

journal_title：International journal of oncology

authors： Płuciennik E,Nowakowska M,Pospiech K,Stępień A,Wołkowicz M,Gałdyszyńska M,Popęda M,Wójcik-Krowiranda K,Bieńkiewicz A,Bednarek AK

更新日期：2015-01-01 00:00:00

abstract：:Overexpression of inducible nitric oxide synthase (iNOS) and the resultant overproduction of NO has been implicated in neuronal inflammatory diseases. Leptomycin B (LMB), a metabolite of Streptomyces, has been identified as a specific inhibitor of CRM1 nuclear export receptor. In this study, we evaluated the effect of...

journal_title：International journal of oncology

authors： Jang BC,Sung SH,Park JG,Park JW,Suh MH,Choi IH,Yoshida M,Yoo SK,Suh SI

更新日期：2006-12-01 00:00:00

abstract：:Acquirement of multi-drug resistance by tumor cells represents a major obstacle in the management of prostate cancer. Such resistance was demonstrated in the androgen-independent DU-145 cells in response to paclitaxel and the mechanisms by which these cell develops resistance was not understood. The objective of this ...

journal_title：International journal of oncology

authors： Flynn V Jr,Ramanitharan A,Moparty K,Davis R,Sikka S,Agrawal KC,Abdel-Mageed AB

更新日期：2003-08-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:Gicerin, an immunoglobulin superfamily protein, is expressed abundantly in the embryonic tissues and plays an important role in development through its cell adhesive activity. Interestingly, re-expression of gicerin is found in a variety of tumors. In the present study, the possible role of gicerin in the progression ...

journal_title：International journal of oncology

authors： Tsukamoto Y,Sakaiuchi T,Hiroi S,Furuya M,Tsuchiya S,Sasaki F,Miki N,Taira E

更新日期：2003-12-01 00:00:00

abstract：:Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...

journal_title：International journal of oncology

authors： Markaverich B,Alejandro M

更新日期：1997-12-01 00:00:00

abstract：:The hepatitis B virus (HBV) encodes a 16.5 kDa multifunctional protein termed pX or HBx, required for transcription of the viral genome and implicated in the development of hepatocellular carcinoma (HCC) in chronic HBV-infected patients. However, the mechanism of pX-mediated hepatocarcinogenesis remains unknown. pX is...

journal_title：International journal of oncology

authors： Andrisani OM,Barnabas S

更新日期：1999-08-01 00:00:00