High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors.

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...

journal_title：International journal of oncology

authors： Koseki J,Colvin H,Fukusumi T,Nishida N,Konno M,Kawamoto K,Tsunekuni K,Matsui H,Doki Y,Mori M,Ishii H

更新日期：2015-03-01 00:00:00

abstract：:Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...

journal_title：International journal of oncology

authors： Tameda M,Sugimoto K,Shiraki K,Yamamoto N,Okamoto R,Usui M,Ito M,Takei Y,Nobori T,Kojima T,Suzuki H,Uchida M,Uchida K

更新日期：2014-08-01 00:00:00

abstract：:The development of colorectal cancer (CRC) is strongly correlated with the aberrant activation of multiple intracellular signaling transduction cascades including STAT3, ERK, JNK and p38 pathways which usually function redundantly. In addition, crosstalk between these pathways forms a complicated signaling network tha...

journal_title：International journal of oncology

authors： Lin J,Chen Y,Wei L,Shen A,Sferra TJ,Hong Z,Peng J

更新日期：2013-10-01 00:00:00

abstract：:We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...

journal_title：International journal of oncology

authors： Takahara Y,Yogosawa S,Maruyama S,Watanabe N,Yokoyama H,Fukasawa K,Sukenaga Y,Kamiyama J,Izumi M,Wakada M,Zhang H,Yoshizawa K,Kawa S,Nikaido T,Sakai T

更新日期：2006-04-01 00:00:00

abstract：:The incidence of thyroid cancer has increased in the past decades; however, the underlying molecular mechanisms of thyroid cancer tumorigenesis remain unknown. Using sequencing technology, long intergenic non‑protein coding RNA 673 (LINC00673) was identified to be upregulated in several tumor tissues. However, the bio...

journal_title：International journal of oncology

authors： Xia E,Bhandari A,Shen Y,Zhou X,Wang O

更新日期：2018-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. We have previously reported that LASP-1 is a downstream protein of the urokinase type plasminogen activator (uPA). Here we investigated the role of LASP-1 in HCC by a molecular and biological characterization of LASP-1...

journal_title：International journal of oncology

authors： Salvi A,Bongarzone I,Ferrari L,Abeni E,Arici B,De Bortoli M,Scuri S,Bonini D,Grossi I,Benetti A,Baiocchi G,Portolani N,De Petro G

更新日期：2015-05-01 00:00:00

abstract：:Chemotherapy (CT) resistance in ovarian cancer is related to multiple factors, and assessment of these factors is necessary for the development of new drugs and therapeutic regimens. In an effort to identify such determinants, we evaluated the expression of approximately 21,000 genes using DNA microarray screening in ...

journal_title：International journal of oncology

authors： L'Espérance S,Popa I,Bachvarova M,Plante M,Patten N,Wu L,Têtu B,Bachvarov D

更新日期：2006-07-01 00:00:00

abstract：:Human telomerase is a ribonucleoprotein DNA polymerase which maintains the telomeric region of human chromosomes and has been detected in all types of human cancer tested. We used the telomeric repeat amplification protocol (TRAP) assay to examine 71 non-small cell lung carcinomas (NSCLC) and their adjacent normal tis...

journal_title：International journal of oncology

authors： Xinarianos G,Scott FM,Liloglou T,Prime W,Callaghan J,Gosney JR,Field JK

更新日期：1999-11-01 00:00:00

abstract：:To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...

journal_title：International journal of oncology

authors： Frankfurt O,Seckinger D,Sugarbaker E

更新日期：1994-02-01 00:00:00

abstract：:Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent. In this study, using western blot analysis for protein expression and flow cytometry for cell cycle analysis, we determined that the treatment of the LNCaP and PC‑3 prostate c...

journal_title：International journal of oncology

authors： Oak C,Khalifa AO,Isali I,Bhaskaran N,Walker E,Shukla S

更新日期：2018-08-01 00:00:00

abstract：:Advanced metastatic melanoma is a malignant tumor for which there is currently no effective treatment due to resistance development. Ginsenoside Rg3, a saponin component extracted from ginseng roots, has been shown to reduce melanoma cell proliferation by decreasing histone deacetylase 3 and increasing p53 acetylation...

journal_title：International journal of oncology

authors： Meng L,Ji R,Dong X,Xu X,Xin Y,Jiang X

更新日期：2019-06-01 00:00:00

abstract：:The positron-emitting radiohalogens 18F, 75Br, 76Br, and 124I are reviewed regarding their relevance for positron emission tomography (PET) in oncology. Relevant production routes of these cyclotron-generated isotopes are given, followed by publications that deal with applications of these radiohalogens. This article ...

journal_title：International journal of oncology

authors： Glaser M,Luthra SK,Brady F

更新日期：2003-02-01 00:00:00

abstract：:One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine proteases prevent DNA degradation and abrogate other signs of apoptosis in several cell systems (Gorczyca et al, Int J Oncol 1: ...

journal_title：International journal of oncology

authors： Gorczyca W,Ardelt B,Darzynkiewicz Z

更新日期：1993-10-01 00:00:00

abstract：:Despite the introduction of 13-cis-retinoic acid (13-cis-RA) into the current chemotherapy, more than half of high-risk neuroblastoma patients have experienced tumor relapses driven by chemoresistant cancer stem cells (CSCs) that can be isolated by their ability to grow as spheres. Although aldehyde dehydrogenase (ALD...

journal_title：International journal of oncology

authors： Hartomo TB,Van Huyen Pham T,Yamamoto N,Hirase S,Hasegawa D,Kosaka Y,Matsuo M,Hayakawa A,Takeshima Y,Iijima K,Nishio H,Nishimura N

更新日期：2015-03-01 00:00:00

abstract：:Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....

journal_title：International journal of oncology

authors： Liu T,Mendes DE,Berkman CE

更新日期：2014-03-01 00:00:00

abstract：:Pleomorphic adenomas (PAs) of salivary glands are characterized by the mixed appearance of epithelial and mesenchymal-like components such as myxoid and chondroid tissues. Although various studies have examined PAs, thus far it is not clear how PAs make these multiple components. Thus, clarification of the histodiffer...

journal_title：International journal of oncology

authors： Kitagawa M,Ogawa I,Shima K,Hashimoto S,Kudo Y,Miyauchi M,Tahara H,Shimono M,Takata T

更新日期：2007-08-01 00:00:00

abstract：:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a ...

journal_title：International journal of oncology

authors： Park YK,Cho CH,Chi SG,Han CS,Ushigome S,Unni KK

更新日期：2001-10-01 00:00:00

abstract：:Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...

journal_title：International journal of oncology

authors： Gebhart E,Verdorfer I,Saul W,Trautmann U,Brecevic L

更新日期：2000-06-01 00:00:00

abstract：:Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant tumor, for which only a few cultured cell lines are available to date. In the present study, we established three new MPNST cell lines, FU-SFT8611, FU-SFT8710 and FU-SFT9817, from a 40-year-old Japanese man without neurofibromatosis 1 (NF1), a 43-year...

journal_title：International journal of oncology

authors： Aoki M,Nabeshima K,Nishio J,Ishiguro M,Fujita C,Koga K,Hamasaki M,Kaneko Y,Iwasaki H

更新日期：2006-12-01 00:00:00

abstract：:There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the risk of breast cancer with respect to circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding...

journal_title：International journal of oncology

authors： Kahán Z,Gardi J,Nyári T,Földesi I,Hajnal-Papp R,Ormándi K,Lázár G,Thurzó L,Schally AV

更新日期：2006-07-01 00:00:00

abstract：:We investigated trans-activating effects of the full-length E6 protein of HPV-16 (16E6) and the E6 protein of HPV-11 (11E6) on the PE1E4 promoter of HPV-11 in C33A cells which lack normal function of p53. 16E6 showed no significant activation of the reporter plasmid containing PE1E4 and the upstream sequence, includin...

journal_title：International journal of oncology

authors： Tomita Y,Asano Y,Shirasawa H

更新日期：1998-12-01 00:00:00

abstract：:On the basis of immunological results, it is not in doubt that the immune system is able to recognize and eliminate transformed cells. A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and ...

journal_title：International journal of oncology

authors： Scutti JAB

更新日期：2018-04-01 00:00:00

abstract：:Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and p...

journal_title：International journal of oncology

authors： Haneji T,Hirashima K,Teramachi J,Morimoto H

更新日期：2013-06-01 00:00:00

abstract：:Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...

journal_title：International journal of oncology

authors： Hardell L,Fredrikson M,Axelson O

更新日期：1996-03-01 00:00:00

abstract：:We have carried out three rounds of screening tests using 239 synthetic tripeptides for the growth-inhibitory activity toward tumor cells and found that those having amino acid sequences of Pro-Thr-Trp or Glu-Arg-Pro effectively inhibit proliferation of transformed cells. These peptides could be the fundamental struct...

journal_title：International journal of oncology

authors： Hiwasa T,Soeda C,Takanohashi S,Kobayashi H,Suzuki A,Ueyama T,Ike Y

更新日期：1996-01-01 00:00:00

abstract：:Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that...

journal_title：International journal of oncology

authors： Poofery J,Sripanidkulchai B,Banjerdpongchai R

更新日期：2020-04-01 00:00:00

abstract：:The Stockholm Central Railway Station in Sweden was investigated for public radiofrequency (RF) radiation exposure. The exposimeter EME Spy 200 was used to collect the RF exposure data across the railway station. The exposimeter covers 20 different radiofrequency bands from 88 to 5,850 MHz. In total 1,669 data points ...

journal_title：International journal of oncology

authors： Hardell L,Koppel T,Carlberg M,Ahonen M,Hedendahl L

更新日期：2016-10-01 00:00:00

abstract：:The growth of normal human breast epithelial cells in vitro, as well as those of other cell types is strongly influenced by the concentration of calcium in the culture medium [Ca++]e. The aim of this study was to ascertain if calcium also affects breast tumor cell growth in vitro. To address this question, the metasta...

journal_title：International journal of oncology

authors： Vandewalle B,Hornez L,Lassalle B,Revillion F,Bertout M,Lefebvre J

更新日期：1993-04-01 00:00:00

abstract：:Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 ...

journal_title：International journal of oncology

authors： Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht U

更新日期：2010-04-01 00:00:00