Abstract:
:Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 recently stepped out of the shadow of SIRT1 showing strong effects on stress response, apoptosis, cell cycle and energy metabolism, mimicking effects of caloric restriction. We have identified two non-synonymous human SIRT3 SNPs and evaluated their impact on SIRT3 activity and stability. We assessed their influence on cellular energy metabolism in relation to SIRT1 and identified SIRT3 to increase cellular respiration by 80% when compared to SIRT1, which increased cellular respiration by only 30%.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht Udoi
10.3892/ijo_00000574subject
Has Abstractpub_date
2010-04-01 00:00:00pages
955-60issue
4eissn
1019-6439issn
1791-2423journal_volume
36pub_type
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