Delimiting the use of comparative genomic hybridization in human myeloid neoplastic disorders.

abstract：:Increased expression levels of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) have been associated with enhanced proliferation and metastasis of several cancer cell types. Hypoxia, a hallmark characteristic of solid tumors, has been linked to an increase in the activity of the ...

journal_title：International journal of oncology

authors： Sallé-Lefort S,Miard S,Nolin MA,Boivin L,Paré MÈ,Debigaré R,Picard F

更新日期：2016-10-01 00:00:00

abstract：:Subsequently to the publication of the above paper, the authors have realized that the images presented in Fig. 1A were selected erroneously (essentially, the images for group 'AdBMP9 +++' were chosen to represent the group 'AdGFP'). A corrected version of Fig. 1, including the correct data for the experiments depicte...

journal_title：International journal of oncology

authors： Wu N,Li R,Meng Z,Nie M,Chen Q,He B,Deng Z,Yin L

更新日期：2019-08-01 00:00:00

abstract：:TP53 gene, encoding tumor protein P53, is frequently inactivated in various types of human cancer, including colorectal, lung, and gastric cancer. Cancer cells with TP53 mutation acquire malignant potentials, such as selective growth advantage, genomic instability, resistance to apoptosis, and promotion of angiogenesi...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-07-01 00:00:00

abstract：:Ovarian cancer is a lethal malignancy, rarely diagnosed early, and there is currently little, if any, preventive strategies which can be followed. This study attempts to identify lifestyle profiles which might be associated with ovarian cancer, and could then be subject to subsequent modification in an effort to preve...

journal_title：International journal of oncology

authors： Loesch M,Fischer M,Shurpin K,Mann W

更新日期：1994-03-01 00:00:00

abstract：:The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...

journal_title：International journal of oncology

authors： Gao Y,Li L,Li T,Ma L,Yuan M,Sun W,Cheng HL,Niu L,Du Z,Quan Z,Fan Y,Fan J,Luo C,Wu X

更新日期：2019-06-01 00:00:00

abstract：:We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-...

journal_title：International journal of oncology

authors： Yoshida H,Enomoto H,Miyauchi M,Takenaga K,Tanabe M,Ohnuma N,Sakiyama S,Tagawa M

更新日期：1998-05-01 00:00:00

abstract：:Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to hepatocellular carcinoma (HCC) is currently unknown. The aim of this study was t...

journal_title：International journal of oncology

authors： Li L,Dong L,Qu X,Jin S,Lv X,Tan G

更新日期：2016-04-01 00:00:00

abstract：:Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a s...

journal_title：International journal of oncology

authors： Choi YM,An S,Lee EM,Kim K,Choi SJ,Kim JS,Jang HH,An IS,Bae S

更新日期：2012-07-01 00:00:00

abstract：:Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...

journal_title：International journal of oncology

authors： Patel MR,Sadiq AA,Jay-Dixon J,Jirakulaporn T,Jacobson BA,Farassati F,Bitterman PB,Kratzke RA

更新日期：2012-02-01 00:00:00

abstract：:Recent studies have shown that chromosome 8p21-22 is the main site of frequent loss of heterozygosity (LOH) in breast cancers. However, the detailed molecular analysis of chromosome 8 so far in breast cancer has been variable. Most of the literature pertaining to LOH in breast cancer is mainly on short arm of chromoso...

journal_title：International journal of oncology

authors： Dahiya R,Perinchery G,Deng G,Lee C

更新日期：1998-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

journal_title：International journal of oncology

authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

更新日期：1993-04-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the most common cancers in the world. Previously, we found that the level of glucocorticoid receptor was significantly higher in hepatocellular carcinoma than in adjacent liver tissues. Moreover, in vitro and in vivo studies showed that glucocorticoid stimulated the growth of hepatom...

journal_title：International journal of oncology

authors： Uen YH,Ko PH,Yin PH,Liu TY,Chi CW,Lui WY

更新日期：2008-12-01 00:00:00

abstract：:The development of clinical agents remains a costly and time-consuming process. Although identification of new uses of existing drugs has been recognized as a more efficient approach for drug discovery than development of novel drugs, little screening of drugs that might be used for a rare malignant tumor such as oste...

journal_title：International journal of oncology

authors： Oi T,Asanuma K,Matsumine A,Matsubara T,Nakamura T,Iino T,Asanuma Y,Goto M,Okuno K,Kakimoto T,Yada Y,Sudo A

更新日期：2016-12-01 00:00:00

abstract：:Toxicity of polyphenols against rat 3Y1 fibroblasts and the cells transformed by human adenovirus (Ad12-3Y1), its EIA gene (EIA-3Y1), or simian virus 40 (SV-3Y1) was examined. Among the diphenol compounds examined, pyrocatechol (o-diphenol) and hydroquinone (p-diphenol) showed selective toxicity against Ad12-3Y1 and E...

journal_title：International journal of oncology

authors： Yamada K,Mitsui T,Okuda A,Kimura G,Sugano M

更新日期：1993-01-01 00:00:00

abstract：:Tanshinone IIA (TSIIA), a natural diterpene quinone in the traditional Chinese medicinal herb Dan-Shen (Salvia miltiorrhiza), has extensively exerted antitumor activity in cellular and animal models. However, the molecular mechanisms underlying the antitumor effects of TSIIA remain largely unknown. The in vitro effect...

journal_title：International journal of oncology

authors： Zhang J,Wang J,Jiang JY,Liu SD,Fu K,Liu HY

更新日期：2014-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a major cause of cancer deaths. Concurrent administration of radiation and chemotherapy is the treatment of choice for advanced NPC. Previously, we showed that apogossypolone (ApoG2) induced apoptosis by blocking the binding of Bcl-2 to Bax, arresting the cell cycle in the S phase, in...

journal_title：International journal of oncology

authors： He JH,Liao XL,Wang W,Li DD,Chen WD,Deng R,Yang D,Han ZP,Jiang JW,Zhu XF

更新日期：2014-09-01 00:00:00

abstract：:Early gastric cancers (EGC) may be subdivided into 2 groups by means of the use of mitotic index, apoptotic index and cell density: EGCs with high cell turnover and low cell density, which show high cell dissociation and, more frequently, lymph node invasion; EGCs with low cell turnover and high cell density. The same...

journal_title：International journal of oncology

authors： Spina D,Miracco C,Vindigni C,Gallorini M,Presenti L,Marrelli D,Roviello F,Pinto E,Filipe MI,Tosi P

更新日期：1998-04-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignancy of the bone. There have been some advances in surgical and chemotherapeutic strategies, but it is still a tumor with a high mortality rate in children and young adults. Mitogen-activated protein kinase/extracellular signal regulated...

journal_title：International journal of oncology

authors： Si H,Peng C,Li J,Wang X,Zhai L,Li X,Li J

更新日期：2012-04-01 00:00:00

abstract：:Human squamous cell carcinomas frequently overexpress the epidermal growth factor receptor (EGFR) and this is often associated with poor prognosis in patients with these cancers. The high level of expression of the EGFR provides an important target for therapy and we and others have shown that monoclonal antibodies (m...

journal_title：International journal of oncology

authors： Modjtahedi H,Affleck K,Stubberfield C,Dean C

更新日期：1998-08-01 00:00:00

abstract：:Because K-Ras mutation and cyclooxygenase-2 (COX-2) overexpression are hallmarks of majority of pancreatic cancer patients, an approach to inhibit the progression and growth of pancreatic cancer using the simultaneous administration of agents that inhibit the function of both targets, should be considered. In the pres...

journal_title：International journal of oncology

authors： Ding N,Cui XX,Gao Z,Huang H,Wei X,Du Z,Lin Y,Shih WJ,Rabson AB,Conney AH,Hu C,Zheng X

更新日期：2014-06-01 00:00:00

abstract：:The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of ma...

journal_title：International journal of oncology

authors： Pankratova S,Nielsen BN,Shiraishi T,Nielsen PE

更新日期：2010-01-01 00:00:00

abstract：:We describe and discuss the findings by fluorescent in situ hybridization (FISH) for detection of non-random chromosomal gains, in a group of unusual fibrous lesions in children. Nuclear disaggregation was used to prepare slides from eight cases which were hybridized using alpha-satellite enumeration probes for chromo...

journal_title：International journal of oncology

authors： Flores-Stadler EM,Chou PM,Barquin N,Thangavelu M,Gonzalez-Crussi F

更新日期：2000-09-01 00:00:00

abstract：:Tumor-bearing mice with two different locally growing malignant tumors (epithelial like, MCG 101; malignant melanoma, K1735-M2) were used to evaluate the putative role of prostaglandins for survival and local tumor growth in experimental cancer. Daily systemic injections of indomethacin (1 mu g/g bw) were used to bloc...

journal_title：International journal of oncology

authors： Lonnroth C,Svaninger G,Gelin J,Cahlin C,Iresjo B,Cvetkovska E,Edstrom S,Andersson M,Svanberg E,Lundholm K

更新日期：1995-12-01 00:00:00

abstract：:Specific chromosomal abnormalities, such as del(7q), t(12;14), 12 trisomy, or the rearrangement of 6p, are seen in approximately 30% of uterine leiomyomas despite their benign status. We investigated the association between the shrinkage of uterine leiomyomas treated with a GnRH agonist and the interstitial deletion o...

journal_title：International journal of oncology

authors： Takahashi K,Kawamura N,Tsujimura A,Ichimura T,Ito F,Ishiko O,Ogita S

更新日期：2001-06-01 00:00:00

abstract：:Polymerase chain reaction (PCR) has been reported as one of the most efficient techniques to detect hepatitis C virus (HCV) RNA. The determination of the specificity of PCR products is usually based on 'nested' PCR, Southern blotting and hybridization of the amplified DNA to radioactive oligonucleotide probes recogniz...

journal_title：International journal of oncology

authors： Bianchi N,Mischiati C,Feriotto G,Gambari R

更新日期：1994-04-01 00:00:00

abstract：:We examined the optimal duration of whole body hyperthermia (WBH, 41.5 degrees C) when administered simultaneously with cis-diamminedichloroplatinum(II) (CDDP) using F344 rat fibrosarcoma model. The antitumor efficacy was measured by tumor growth delay (TGD) and nephrotoxicity was evaluated by the day 5 blood urea nit...

journal_title：International journal of oncology

authors： Makino M,Ohno S,Sakaguchi Y,Kaneko T,Strebel F,Jenkins G,Bull J

更新日期：1997-02-01 00:00:00

abstract：:Growth and inflammatory factors are associated with poor prognosis in gastric adenocarcinoma (GA); however, the additive effects of growth and inflammatory factors in GA remain unclear. In this study, we investigated the ability of epidermal growth factor (EGF) and interleukin (IL-1β) to activate extracellular signal-...

journal_title：International journal of oncology

authors： Han J,Xie Y,Lan F,Yu Y,Liu W,Chen J,Zheng F,Ouyang X,Lin X,Lin Y,Huang Q,Wang L,Tan J

更新日期：2014-07-01 00:00:00

abstract：:The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...

journal_title：International journal of oncology

authors： Thakkar A,Chenreddy S,Wang J,Prabhu S

更新日期：2015-04-01 00:00:00

abstract：:Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...

journal_title：International journal of oncology

authors： Leung H,Hughes C,Kloppel G,Williamson R,Lemoine N

更新日期：1994-06-01 00:00:00