Percutaneous ethanol injection therapy for hepatocellular-carcinoma (review).

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:The human ovarian cancer cell line OV-MZ-19, established from a patient with cystadenocarcinoma of the ovary, expressing thrombomodulin (TM), a cell surface receptor for the serine protease thrombin, interacts with monoclonal and polyclonal antibodies having different specificity for TM. These antibodies detect TM ant...

journal_title：International journal of oncology

authors： Wilhelm S,Schmitt M,Parkinson J,Kuhn W,Graeff H,Wilhelm OG

更新日期：1998-10-01 00:00:00

abstract：:Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...

journal_title：International journal of oncology

authors： Ota K,Fujimori H,Ueda M,Jono H,Shinriki S,Ota T,Sueyoshi T,Taura M,Taguma A,Kai H,Shinohara M,Ando Y

更新日期：2010-10-01 00:00:00

abstract：:Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...

journal_title：International journal of oncology

authors： Gil EY,Jo UH,Jeong H,Whang YM,Woo OH,Cho KR,Seo JH,Kim A,Lee ES,Koh I,Kim YH,Park KH

更新日期：2012-08-01 00:00:00

abstract：:Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...

journal_title：International journal of oncology

authors： Michaelidou K,Tzovaras A,Missitzis I,Ardavanis A,Scorilas A

更新日期：2013-05-01 00:00:00

abstract：:Sterile alpha motif and histidine/aspartic acid domain‑containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools. Furthermore, SAMHD1 has been reported to be involved in the pathological p...

journal_title：International journal of oncology

authors： Zhang Z,Zheng L,Yu Y,Wu J,Yang F,Xu Y,Guo Q,Wu X,Cao S,Cao L,Song X

更新日期：2020-04-01 00:00:00

abstract：:Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...

journal_title：International journal of oncology

authors： Tennstedt P,Köster P,Brüchmann A,Mirlacher M,Haese A,Steuber T,Sauter G,Huland H,Graefen M,Schlomm T,Minner S,Simon R

更新日期：2012-01-01 00:00:00

abstract：:Cancer stem cells (CSC) exhibit therapy resistance and drive self-renewal of the tumour, making cancer stem cells an important target for therapy. The PI3K signalling pathway has been the focus of considerable research effort, including in glioblastoma (GBM), a cancer that is notoriously resistant to conventional ther...

journal_title：International journal of oncology

authors： Jones NM,Rowe MR,Shepherd PR,McConnell MJ

更新日期：2016-07-01 00:00:00

abstract：:We have previously demonstrated the multipotent nature of human umbilical cord blood stem cells (hUCB). In this study, we have attempted to show the use of hUCB in glioma therapy. We used hUCB enriched in CD44 and CD133 cells for our studies and observed that glioma cells co-cultured with hUCB undergo apoptosis. To pr...

journal_title：International journal of oncology

authors： Gondi CS,Gogineni VR,Chetty C,Dasari VR,Gorantla B,Gujrati M,Dinh DH,Rao JS

更新日期：2010-05-01 00:00:00

abstract：:The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...

journal_title：International journal of oncology

authors： Moriya S,Komatsu S,Yamasaki K,Kawai Y,Kokuba H,Hirota A,Che XF,Inazu M,Gotoh A,Hiramoto M,Miyazawa K

更新日期：2015-02-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:The p16INK4A tumor suppressor gene is frequently inactivated in non-small cell lung carcinoma (NSCLC) and is less frequently inactivated in small cell lung carcinoma (SCLC) by mutation, deletion or DNA methylation. There are several reports that the reintroduction of the p16INK4A gene into p16(-) NSCLC cells results i...

journal_title：International journal of oncology

authors： Sumitomo K,Shimizu E,Shinohara A,Yokota J,Sone S

更新日期：1999-06-01 00:00:00

abstract：:We examined the expression levels of P-glycoprotein (P-Gp)/the human multidrug resistance gene (MDR1) and in vivo chemosensitivity in the 7 osteosarcoma xenografts. Three of seven (43%) osteosarcoma xenografts expressed MDR1 by reverse transcriptase-polymerase chain reaction (RT-PCR). The OSS-516R xenograft selected w...

journal_title：International journal of oncology

authors： Suto R,Abe Y,Nakamura M,Ohnishi Y,Yoshimura M,Lee YH,Imanishi T,Yamazaki H,Kijima H,Tokunaga T,Oshika Y,Hiraoka N,Tamaoki N,Fukuda H,Ueyama Y

更新日期：1998-02-01 00:00:00

abstract：:Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune res...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：2015-12-01 00:00:00

abstract：:Cancer represents a severe challenge to healthcare systems and individuals worldwide. The development of multiple drug resistance is a major issue regarding cancer therapy, which can result in the progression of disease. Cholesterol is a major constituent of cell membranes and participates in the regulation of several...

journal_title：International journal of oncology

authors： Yan A,Jia Z,Qiao C,Wang M,Ding X

更新日期：2020-09-22 00:00:00

abstract：:Lung cancer is a prevalent disease and is one of the leading causes of mortality worldwide. Despite the development of various anticancer drugs, the prognosis of lung cancer is relatively poor. Metastasis of lung cancer, as well as chemoresistance, is associated with a high mortality rate for patients with lung cancer...

journal_title：International journal of oncology

authors： Chiu YH,Hsu SH,Hsu HW,Huang KC,Liu W,Wu CY,Huang WP,Chen JY,Chen BH,Chiu CC

更新日期：2018-11-01 00:00:00

abstract：:We examined the optimal duration of whole body hyperthermia (WBH, 41.5 degrees C) when administered simultaneously with cis-diamminedichloroplatinum(II) (CDDP) using F344 rat fibrosarcoma model. The antitumor efficacy was measured by tumor growth delay (TGD) and nephrotoxicity was evaluated by the day 5 blood urea nit...

journal_title：International journal of oncology

authors： Makino M,Ohno S,Sakaguchi Y,Kaneko T,Strebel F,Jenkins G,Bull J

更新日期：1997-02-01 00:00:00

abstract：:We performed interventional treatments on 50 patients with hepatocellular carcinoma (HCC) and analyzed the relationship between these treatments and the exacerbation of liver function after treatment. The different treatments included transcatheter arterial embolization (TAE), percutaneous ethanol injection therapy (P...

journal_title：International journal of oncology

authors： Okano H,Shiraki K,Inoue H,Deguchi M,Sugimoto K,Sakai T,Ohmori S,Murata K,Nakano T,Yamakado K,Takeda K

更新日期：2001-12-01 00:00:00

abstract：:Primary intracerebral lymphoma is an uncommon presenting site for non-Hodgkin's lymphoma. The authors review 28 histopathologically confirmed, consecutive cases, presenting over a 15-year period. The cohort included 20 males and 8 females with a mean age at diagnosis of 54 years (range 27-75 years). Subtotal resection...

journal_title：International journal of oncology

authors： Hough RE,Smith CM,Nakielny RA,Robinson MH,Jacubowski J,Lorigan PC,Hancock BW

更新日期：1999-04-01 00:00:00

abstract：:Selenium is a trace nutrient element that protects cells against oxidative damage. In this study, the potential of selenium to improve stem cell potency through active proliferation and migration of 3T3-L1 preadipocytes was investigated, together with the underlying molecular mechanisms. The results indicated that sel...

journal_title：International journal of oncology

authors： Park SH,Kim JH,Nam SW,Kim BW,Kim GY,Kim WJ,Choi YH

更新日期：2014-01-01 00:00:00

abstract：:The poor prognosis of Ewing's sarcoma (EWS), together with its high lethal recurrence rate and the side‑effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side‑effects. The oncogenic chimeric protein EWS/FLI1 is the key malignancy driver in mo...

journal_title：International journal of oncology

authors： Sengupta A,Rahman M,Mateo-Lozano S,Tirado OM,Notario V

更新日期：2013-09-01 00:00:00

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

journal_title：International journal of oncology

authors： Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

更新日期：2007-02-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome that is the main cause of inherited clear-cell renal cell carcinoma (ccRCC), which generally occurs in the form of multiple recurrent synchronized tumors. Affected patients are carriers of a germline mutation in the VHL tumor suppressor gene. Somati...

journal_title：International journal of oncology

authors： Gattolliat CH,Couvé S,Meurice G,Oréar C,Droin N,Chiquet M,Ferlicot S,Verkarre V,Vasiliu V,Molinié V,Méjean A,Dessen P,Giraud S,Bressac-De-Paillerets B,Gardie B,Tean Teh B,Richard S,Gad S

更新日期：2018-10-01 00:00:00

abstract：:WNT signals are transduced to the planar cell polarity (PCP) pathway or the beta-catenin pathway. Drosophila Frizzled (Fz), Starry night (Stan), Van Gogh (Vang), Dishevelled (Dsh), Prickle (Pk), Diego (Dgo) and Nemo (Nmo) are implicated in the PCP signaling pathway. Choi and Benzer identified Drosophila Nmo in 1994, a...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-06-01 00:00:00

abstract：:177Lu‑DOTATATE was recently approved for the treatment of somatostatin receptor (SSTR)‑positive neuroendocrine tumors (NETs). However, despite impressive response rates, complete responses are rare. Heat shock protein 90 (HSP90) inhibitors have been suggested as suitable therapeutic agents for NETs, as well as a poten...

journal_title：International journal of oncology

authors： Lundsten S,Spiegelberg D,Stenerlöw B,Nestor M

更新日期：2019-12-01 00:00:00

abstract：:Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...

journal_title：International journal of oncology

authors： Leung H,Hughes C,Kloppel G,Williamson R,Lemoine N

更新日期：1994-06-01 00:00:00

abstract：:The development of clinical agents remains a costly and time-consuming process. Although identification of new uses of existing drugs has been recognized as a more efficient approach for drug discovery than development of novel drugs, little screening of drugs that might be used for a rare malignant tumor such as oste...

journal_title：International journal of oncology

authors： Oi T,Asanuma K,Matsumine A,Matsubara T,Nakamura T,Iino T,Asanuma Y,Goto M,Okuno K,Kakimoto T,Yada Y,Sudo A

更新日期：2016-12-01 00:00:00

abstract：:Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...

journal_title：International journal of oncology

authors： Baillargeon J,Rose DP

更新日期：2006-03-01 00:00:00

abstract：:High consumption of soy products in some Asian countries has been linked to the low incidence of breast cancer in women. The chemopreventive effect of the soy isoflavone, genistein, has been observed through the suppression of cell proliferation, inhibition of angiogenesis and stimulation of apoptosis in breast carcin...

journal_title：International journal of oncology

authors： Valachovicova T,Slivova V,Bergman H,Shuherk J,Sliva D

更新日期：2004-11-01 00:00:00