Analysis of cell kinetics after gamma-ray irradiation using an anti-BrdU monoclonal antibody.

abstract：:The epithelial-to-mesenchymal transition (EMT) confers an aggressive subtype associated with chemotherapy resistance in epithelial cancers. However, the mechanisms underlying the EMT and its associated signaling dysfunctions are still poorly understood. In two genetic models of MCF-...

journal_title：International journal of oncology

authors： Ouelaa-Benslama R,De Wever O,Hendrix A,Sabbah M,Lambein K,Land D,Prévost G,Bracke M,Hung MC,Larsen AK,Emami S,Gespach C

更新日期：2012-07-01 00:00:00

abstract：:Dihydropyrimidine dehydrogenase (DPD) is the first and rate-limiting enzyme in the degradation of pyrimidines and pyrimidine base analogs including the anticancer drugs 5-fluorouracil (5-FU) and Xeloda. A decreased DPD enzyme activity has been described in cancer patients experiencing severe and life-threatening toxic...

journal_title：International journal of oncology

authors： Gross E,Seck K,Neubauer S,Mayr J,Hellebrand H,Ratanaphan A,Lutz V,Stockinger H,Kiechle M

更新日期：2003-02-01 00:00:00

abstract：:The deregulation of the epidermal growth factor receptor (EGFR) pathway plays a major role in the pathogenesis of prostate cancer (PCa). However, therapies targeting EGFR have demonstrated limited effectiveness in PCa. A potential mechanism to overcome EGFR blockade in cancer cells is the autocrine activation of alter...

journal_title：International journal of oncology

authors： Carrión-Salip D,Panosa C,Menendez JA,Puig T,Oliveras G,Pandiella A,De Llorens R,Massaguer A

更新日期：2012-09-01 00:00:00

abstract：:Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vecto...

journal_title：International journal of oncology

authors： Yamanaka R

更新日期：2004-04-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphomas usually involve extranodal sites, especially the stomach, lung and salivary glands. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14) (p22;q32) in MALT lymphomas, and considered to be an apoptosis-associated gene, and involves a caspase recrui...

journal_title：International journal of oncology

authors： Ohshima K,Muta H,Kawasaki C,Muta K,Deyev V,Kanda M,Kumano Y,Podack ER,Kikuchi M

更新日期：2001-08-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity induced by 5-FU alon...

journal_title：International journal of oncology

authors： Lamberti M,Porto S,Zappavigna S,Stiuso P,Tirino V,Desiderio V,Mele L,Caraglia M

更新日期：2015-05-01 00:00:00

abstract：:MicroRNAs can govern up to hundred different mRNAs and are important regulators of gene expression programs in development and disease. We analyzed the expression of microRNA-21, one of the most common oncomirs, in non-small cell lung cancer (NSCLC). Using northern blots the microRNA-21 expression levels of NSCLC-deri...

journal_title：International journal of oncology

authors： Haigl B,Vanas V,Setinek U,Hegedus B,Gsur A,Sutterlüty-Fall H

更新日期：2014-04-01 00:00:00

abstract：:Currently, it is not entirely clear whether hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of COX-2 expression and epithelial-to-mesenchymal transition (EMT), and whether these events affect the prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolizati...

journal_title：International journal of oncology

authors： Huang M,Wang L,Chen J,Bai M,Zhou C,Liu S,Lin Q

更新日期：2016-05-01 00:00:00

abstract：:Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cel...

journal_title：International journal of oncology

authors： Zwergel T,Burk U,Herter S,Lindenmeir T,Wullich B,Unteregger G

更新日期：1995-12-01 00:00:00

abstract：:Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...

journal_title：International journal of oncology

authors： Rieger C,Huebner D,Temme A,Wirth MP,Fuessel S

更新日期：2015-09-01 00:00:00

abstract：:Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. F...

journal_title：International journal of oncology

authors： Papadakis E,Malliri A,Linardopoulos S,Karaiossifidi H,Field J,Spandidos D

更新日期：1992-09-01 00:00:00

abstract：:Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...

journal_title：International journal of oncology

authors： Williams J,Maitland N,Mott M,Brown K

更新日期：1992-12-01 00:00:00

abstract：:The interactions between cells and the extracellular matrix (EM) have important effects on tumor invasion and metastasis. Osteosarcoma (OS) is a highly metastatic tumor, secondary lesions occurring early in the natural history of the disease. Despite the clinical relevance of disseminated disease in this neoplasia, th...

journal_title：International journal of oncology

authors： Scotlandi K,Serra M,Manara M,Nanni P,Nicoletti G,Landuzzi L,Maurici D,Baldini N

更新日期：1993-11-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC), the most common esophageal cancer in East Asia, is among the six cancers with the highest fatality rates worldwide. Unfortunately, multidisciplinary treatment strategies have not achieved satisfactory outcomes. Therefore, novel insights into the molecular biology of ESCC are ...

journal_title：International journal of oncology

authors： Tanaka H,Kanda M,Koike M,Iwata N,Shimizu D,Ezaka K,Sueoka S,Tanaka Y,Takami H,Hashimoto R,Tanaka C,Yamada S,Fujii T,Nakayama G,Sugimoto H,Fujiwara M,Kodera Y

更新日期：2015-11-01 00:00:00

abstract：:We have reported that ONO-4007, a novel synthetic lipid A derivative with low toxic activities, produced large amount of tumor necrosis factor (TNF)-alpha selectively in the tumor tissues and brought about complete cures in about 60% of rats bearing TNF-alpha sensitive KDH-8 cells, which also secreted a large amount o...

journal_title：International journal of oncology

authors： Matsushita K,Kuramitsu Y,Ohiro Y,Kobayashi I,Watanabe T,Kobayashi M,Hosokawa M

更新日期：2003-08-01 00:00:00

abstract：:Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in r...

journal_title：International journal of oncology

authors： Tsukamoto S,Honoki K,Fujii H,Tohma Y,Kido A,Mori T,Tsujiuchi T,Tanaka Y

更新日期：2012-01-01 00:00:00

abstract：:We previously reported in a retrospective study that CEA-based RT-PCR was useful for predicting the prognosis of patients with node-negative colorectal cancer. RT-PCR is well established for laboratory use, but many issues remain to be resolved prior to its clinical application. In addition to the false positive rate ...

journal_title：International journal of oncology

authors： Takayama O,Yamamoto H,Ikeda K,Ishida H,Kato T,Okuyama M,Kanou T,Fukunaga M,Tominaga S,Morita S,Fujie Y,Fukunaga H,Ikenaga M,Ikeda M,Ohue M,Sekimoto M,Kikkawa N,Monden M

更新日期：2004-09-01 00:00:00

abstract：:Pleomorphic adenomas (PAs) of salivary glands are characterized by the mixed appearance of epithelial and mesenchymal-like components such as myxoid and chondroid tissues. Although various studies have examined PAs, thus far it is not clear how PAs make these multiple components. Thus, clarification of the histodiffer...

journal_title：International journal of oncology

authors： Kitagawa M,Ogawa I,Shima K,Hashimoto S,Kudo Y,Miyauchi M,Tahara H,Shimono M,Takata T

更新日期：2007-08-01 00:00:00

abstract：:Ewing's sarcoma (ES) is a rare tumor that is more frequent in pediatric and adolescent age groups. In the past few decades, long-term survival in affected patients has improved due to the success of multimodal therapy. However, long-term survival is inevitably restricted by the late side-effects of chemotherapy. Besid...

journal_title：International journal of oncology

authors： Ye C,Yu X,Zeng J,Dai M,Zhang B

更新日期：2017-12-01 00:00:00

abstract：:High lactate production in cells during growth under oxygen-rich conditions (aerobic glycolysis) is a hallmark of tumor cells, indicating the role of mitochondrial function in tumorigenesis. In fact, enhanced mitochondrial biogenesis and impaired quality control are frequently observed in cancer cells. Mitochondrial D...

journal_title：International journal of oncology

authors： Jiménez-Morales S,Pérez-Amado CJ,Langley E,Hidalgo-Miranda A

更新日期：2018-09-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is cytotoxic to the majority of cancer cells while sparing most normal cells. However, different prostate carcinoma cell lines respond with different sensitivities to TRAIL, urging us to disclose the mechanisms that determine TRAIL sensitivity in prostate...

journal_title：International journal of oncology

authors： Sonnemann J,Gekeler V,Sagrauske A,Müller C,Hofmann HP,Beck JF

更新日期：2004-10-01 00:00:00

abstract：:Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...

journal_title：International journal of oncology

authors： Konduri S,Lakka SS,Tasiou A,Yanamandra N,Gondi CS,Dinh DH,Olivero WC,Gujrati M,Rao JS

更新日期：2001-09-01 00:00:00

abstract：:We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...

journal_title：International journal of oncology

authors： Hartmann K,Teckentrup R,Nixdorf D,Meuer S,Papa V,Heinrich U

更新日期：1993-06-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological cancer. We identified interleukin 11 (IL11) as a critical mediator of endometrial tumourigenesis and demonstrated that IL11 regulates chondroitin sulfate proteoglycan (CSPG4) in human placental trophoblasts. CSPG4 is a cell membrane protein overexpressed in numerous ...

journal_title：International journal of oncology

authors： Winship A,Van Sinderen M,Heffernan-Marks A,Dimitriadis E

更新日期：2017-03-01 00:00:00

abstract：:Lymphoid hyperplasia of lacrimal gland may be difficult to be differentiated from lymphomas on the basis of morphology and immunohistochemistry. The results of this study indicate that polymerase chain reaction should be employed for confirming the diagnosis of lymphoma in cases with histological and immunophenotypica...

journal_title：International journal of oncology

authors： Leoncini L,Funto I,Lazzi S,Pacenti L,Polito E,Bartolomei A,Leccisotti A,Cintorino M,Tosi P

更新日期：1993-11-01 00:00:00

abstract：:Dissemination of single tumor cells to the bone marrow is a common event in cancer. The clinical significance of cytokeratin-positive cells detected in the bone marrow of cancer patients is still a matter of debate. In gastric cancer, overexpression of the receptor (uPAR or CD87) for the serine protease urokinase-type...

journal_title：International journal of oncology

authors： Noack F,Helmecke D,Rosenberg R,Thorban S,Nekarda H,Fink U,Lewald J,Stich M,Schutze K,Harbeck N,Magdolen V,Graeff H,Schmitt M

更新日期：1999-10-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:Multidrug resistance (MDR) plays a pivotal role in human chronic myelogenous leukemia (CML) chemotherapy failure. MDR is mainly associated with the overexpression of drug efflux transporters of the ATP-binding cassette (ABC) proteins. Phosphoinositide 3-kinase (PI3K)/Akt signaling cascade is involved in the MDR phenot...

journal_title：International journal of oncology

authors： Wang H,Jia XH,Chen JR,Yi YJ,Wang JY,Li YJ,Xie SY

更新日期：2016-12-01 00:00:00

abstract：:To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

journal_title：International journal of oncology

authors： Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

更新日期：1996-06-01 00:00:00