miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer.

abstract：:Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activi...

journal_title：International journal of oncology

authors： Du Y,Long Q,Zhang L,Shi Y,Liu X,Li X,Guan B,Tian Y,Wang X,Li L,He D

更新日期：2015-12-01 00:00:00

abstract：:Gene therapy is a newly hatched field of biomedical research aimed at introducing therapeutically important genes into somatic cells of patients for the treatment of human disease. Whereas for inborn errors of metabolism transfer of a single gene can correct the disorder, cancer is a complex disease involving mutation...

journal_title：International journal of oncology

authors： Boulikas T

更新日期：1996-11-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...

journal_title：International journal of oncology

authors： Chen J,Schmitt A,Giannopoulos K,Chen B,Rojewski M,Döhner H,Bunjes D,Schmitt M

更新日期：2007-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common solid neoplasm of adult kidney, and the major treatment for metastatic RCC (mRCC) is molecular targeted therapy. Sorafenib, as a multi-targeted tyrosine kinase inhibitor (TKI), has significantly improved clinical outcomes of mRCC patients. However, complete or long-term re...

journal_title：International journal of oncology

authors： Zhang P,Xing Z,Li X,Song Y,Zhao J,Xiao Y,Xing Y

更新日期：2016-04-01 00:00:00

abstract：:A monoclonal antibody (MSN-3) was raised using HEC-108 cells derived from poorly differentiated endometrial carcinoma as the immunogen. The immunoglobulin subclass of MSN-3 was IgGr1. The target antigen of MSN-3 was a protein with a molecular weight of 77 kDa, and it was shown to be localized in the cytoplasm. MSN-3 o...

journal_title：International journal of oncology

authors： Hasegawa K,Tsukazaki K,Kubushiro K,Kobayashi Y,Kobiki K,Udagawa Y,Nozawa S

更新日期：1997-10-01 00:00:00

abstract：:Chemo- and radiotherapy induce apoptosis in tumours and surrounding tissues. In a search for robust and reliable apoptosis markers, we have evaluated immunostaining patterns of gammaH2AX and cleaved PARP-1 in paraffin-embedded cellular spheroids. Breast cancer BT474 cells were grown as cell spheroids to diameters of 7...

journal_title：International journal of oncology

authors： Qvarnström OF,Simonsson M,Eriksson V,Turesson I,Carlsson J

更新日期：2009-07-01 00:00:00

abstract：:TGF-β-induced epithelial-mesenchymal transition (EMT) plays an important role in tumor progression. We assessed whether the TGF-β-induced EMT contributed to vasculogenic mimicry (VM) formation in glioma, we established an SHG44 cell line stably transfected with TGF-β cDNA loaded lentivirus. SB203580 was employed to in...

journal_title：International journal of oncology

authors： Ling G,Ji Q,Ye W,Ma D,Wang Y

更新日期：2016-12-01 00:00:00

abstract：:An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in...

journal_title：International journal of oncology

authors： Hwang KA,Kang NH,Yi BR,Lee HR,Park MA,Choi KC

更新日期：2013-02-01 00:00:00

abstract：:We studied the expresssion of estrogen (ER), progesterone (PgR), and androgen receptors (AR) in hepatocellular carcinoma (HCC) and found expression in (7/36), 3.2% (1/31), 16.7% (4/24) of cases, respectively. The expression of ER did not correlate with histological grade, tumor size, or stage of disease. On the other ...

journal_title：International journal of oncology

authors： Ishizu H,Une Y,Gondo H,Kameda H,Uchino J

更新日期：1994-06-01 00:00:00

abstract：:Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...

journal_title：International journal of oncology

authors： Ota K,Fujimori H,Ueda M,Jono H,Shinriki S,Ota T,Sueyoshi T,Taura M,Taguma A,Kai H,Shinohara M,Ando Y

更新日期：2010-10-01 00:00:00

abstract：:We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 c...

journal_title：International journal of oncology

authors： Inoue M,Yano H,Kojiro M

更新日期：1996-07-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) are a family of mitogenic proteins involved in the regulation of cell growth and differentiation. The presence and role of the IGF system in oral mucosal epithelium is not clear but could influence our understanding of the pathogenesis of oral cancer. We characterised the express...

journal_title：International journal of oncology

authors： Brady G,Crean SJ,Naik P,Kapas S

更新日期：2007-10-01 00:00:00

abstract：:An altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease. Malignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues. In this study, we investigated the expression profiles of 340 mammalian ...

journal_title：International journal of oncology

authors： D'Urso PI,D'Urso OF,Storelli C,Mallardo M,Gianfreda CD,Montinaro A,Cimmino A,Pietro C,Marsigliante S

更新日期：2012-07-01 00:00:00

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell l...

journal_title：International journal of oncology

authors： Habibie,Yokoyama S,Abdelhamed S,Awale S,Sakurai H,Hayakawa Y,Saiki I

更新日期：2014-08-01 00:00:00

abstract：:Polymerase chain reaction (PCR) has been reported as one of the most efficient techniques to detect hepatitis C virus (HCV) RNA. The determination of the specificity of PCR products is usually based on 'nested' PCR, Southern blotting and hybridization of the amplified DNA to radioactive oligonucleotide probes recogniz...

journal_title：International journal of oncology

authors： Bianchi N,Mischiati C,Feriotto G,Gambari R

更新日期：1994-04-01 00:00:00

abstract：:Pancreatic cancer is characterized by a dense desmoplastic reaction in which extracellular matrix proteins accumulate and surround tumor cells. Integrins and their related signaling molecules are associated with progression of pancreatic cancer. In the present study, the association between the metastasis of pancreati...

journal_title：International journal of oncology

authors： Jiang P,Li Z,Tian F,Li X,Yang J

更新日期：2017-07-01 00:00:00

abstract：:Gastric carcinoma may occur sporadically or in association with hereditary diseases, such as Peutz-Jehgers syndrome (PJS). The PJS gene (named STK11 or LKB1) was mapped to 19p13.3 and recently cloned. Germ-line mutations of the gene have been detected in familial PJS patients and are predicted to predispose STK11 carr...

journal_title：International journal of oncology

authors： Park WS,Moon YW,Yang YM,Kim YS,Kim YD,Fuller BG,Vortmeyer AO,Fogt F,Lubensky IA,Zhuang Z

更新日期：1998-09-01 00:00:00

abstract：:The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of ma...

journal_title：International journal of oncology

authors： Pankratova S,Nielsen BN,Shiraishi T,Nielsen PE

更新日期：2010-01-01 00:00:00

abstract：:Percutaneous nephrostomy (PN) will rapidly correct renal failure due to ureteral obstruction. Complications of the procedure are few and the procedure can be quickly accomplished on an outpatient basis using local anesthesia. A retrospective review of fifty patients who underwent PN led to derivation of a formula whic...

journal_title：International journal of oncology

authors： McKenna B,Chalas E,Ferretti J,Rothpearl A,Mann W

更新日期：1994-04-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00

abstract：:Previously we have demonstrated that the tumor infiltrating lymphocytes found in SJL/J mice with reticulum cell sarcomas (RCS) are CD4+ T cells which express T cell receptor (TCR) beta chain molecules comprised principally of Vbeta17a encoded variable gene segments. Herein we report both the cellular and molecular cha...

journal_title：International journal of oncology

authors： Katz J,Bonavida B

更新日期：1994-04-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play a pivotal role in tumorigenesis. miR‑34a, which is a member of the miR-34 family, is a downstream target of p53. Increasing evidence shows that miR-34a dysregulation may contribute to tumor development and progression in numerous cancers, includ...

journal_title：International journal of oncology

authors： Yang L,Song X,Zhu J,Li M,Ji Y,Wu F,Chen Y,Cui X,Hu J,Wang L,Cao Y,Wei Y,Zhang W,Li F

更新日期：2017-07-01 00:00:00

abstract：:VSELs are a population of rare Oct-4+CXCR4+ CD133+lin-CD45- cells that are deposited during early embryogenesis in developing organs/tissues as a reserve population of pluripotent stem cells for regeneration. We reported recently that they are mobilized into peripheral blood during acute myocardial infarction (AMI) in...

journal_title：International journal of oncology

authors： Wojakowski W,Tendera M,Kucia M,Zuba-Surma E,Milewski K,Wallace-Bradley D,Kazmierski M,Buszman P,Hrycek E,Cybulski W,Kaluza G,Wieczorek P,Ratajczak J,Ratajczak MZ

更新日期：2010-08-01 00:00:00

abstract：:Steroid receptor analysis is the only widely accepted prognostic/predictive marker in breast cancer (BC) treatment. In the present study we evaluated the prognostic role of ER/PgR with p53 and Bcl2, in a series of 277 BC (153 pN1/2, 122 pNO, 2 pNx) with a long-term follow-up (67 months for DFS, 75 months for OS). Our ...

journal_title：International journal of oncology

authors： Mauri FA,Maisonneuve P,Caffo O,Veronese S,Aldovini D,Ferrero S,Cozzaglio F,Dalla Palma P,Galligioni E,Barbareschi M

更新日期：1999-12-01 00:00:00

abstract：:The purpose of this study was to determine whether the synthesis of endogenous nitric oxide (NO) is involved in the apoptosis of murine L929 transformed fibroblasts. L929 parental cells and L929 cells selected for resistance to tumor necrosis factor (TNF-alpha) were incubated in vitro with various concentrations of TN...

journal_title：International journal of oncology

authors： Xie K,Huang S,Dong Z,Fidler I

更新日期：1993-12-01 00:00:00

abstract：:The ability of lonidamine (LND), an energolytic derivative of indazol-carboxylic acid, to modulate the cytotoxic activity of idarubicin (IDA) and doxorubicin (DX) was investigated in two human lymphoma cell lines (H9 and U937). A different pattern of interaction between the drugs was observed as a function of treatmen...

journal_title：International journal of oncology

authors： Zaffaroni N,Villa R,Gornati D,Folini M,Silvestrini R

更新日期：1997-10-01 00:00:00

abstract：:Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...

journal_title：International journal of oncology

authors： Narayanan R,Kim HN,Narayanan NK,Nargi D,Narayanan B

更新日期：2012-01-01 00:00:00

abstract：:There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-κB. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been perform...

journal_title：International journal of oncology

authors： Huang J,Guo P,Ma D,Lin X,Fang Q,Wang J

更新日期：2016-07-01 00:00:00

abstract：:One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine proteases prevent DNA degradation and abrogate other signs of apoptosis in several cell systems (Gorczyca et al, Int J Oncol 1: ...

journal_title：International journal of oncology

authors： Gorczyca W,Ardelt B,Darzynkiewicz Z

更新日期：1993-10-01 00:00:00