Cardiomyocyte differentiation of bone marrow-derived Oct-4+CXCR4+SSEA-1+ very small embryonic-like stem cells.

abstract：:The effects of prostaglandin E2 and indomethacin on carcinogenesis were studied in male Wistar rats. Of the rats, those treated with MNNG (MNNG group) were given 1 ml of 0.1% solution of MNNG in distilled water by intrarectal instillation every day for 14 days. The diet for the rats treated with Indomethacin and MNNG ...

journal_title：International journal of oncology

authors： Yamaguchi A,Goi T,Nakagawara G,Ishida T,Miyazaki I

更新日期：1993-08-01 00:00:00

abstract：:Adenosine monophosphate-activated protein kinase (AMPK) is a principal intracellular energy sensor which regulates energy producing pathways and energy requiring pathways when the cellular AMP/ATP ratio is altered. BML-275 (compound C), a well-known inhibitor of AMPK, has been found...

journal_title：International journal of oncology

authors： Duong HQ,Hwang JS,Kim HJ,Seong YS,Bae I

更新日期：2012-12-01 00:00:00

abstract：:Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear matrix proteins during HMBA-induced differentiation of human...

journal_title：International journal of oncology

authors： Xu DH,Liu F,Li X,Chen XF,Jing GJ,Wu FY,Shi SL,Li QF

更新日期：2014-07-01 00:00:00

abstract：:Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....

journal_title：International journal of oncology

authors： Liu T,Mendes DE,Berkman CE

更新日期：2014-03-01 00:00:00

abstract：:Activation of intestinal human pregnane X receptor (PXR) has recently been proposed as a promising strategy for the chemoprevention of inflammation-induced colon cancer. The present study was aimed at evaluating the effect of rifaximin, a non-absorbable antibiotic, in inhibiting angiogenesis in a model of human colore...

journal_title：International journal of oncology

authors： Esposito G,Gigli S,Seguella L,Nobile N,D'Alessandro A,Pesce M,Capoccia E,Steardo L,Cirillo C,Cuomo R,Sarnelli G

更新日期：2016-08-01 00:00:00

abstract：:To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...

journal_title：International journal of oncology

authors： Kohnoe S,Maehara Y,Takahashi I,Yoshida M,Emi Y,Baba H,Sugimachi K

更新日期：1993-11-01 00:00:00

abstract：:Mismatch repair (MMR) genes play a fundamental role in the correction of replication errors, leading to cancer development when mutated. In order to test the hypothesis that the MMR system was compromised in the initiation and progression of breast cancer, we used an in vitro-in vivo model for analyzing the mRNA level...

journal_title：International journal of oncology

authors： Balogh GA,Russo IH,Russo J

更新日期：2003-08-01 00:00:00

abstract：:We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...

journal_title：International journal of oncology

authors： Hartmann K,Teckentrup R,Nixdorf D,Meuer S,Papa V,Heinrich U

更新日期：1993-06-01 00:00:00

abstract：:Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...

journal_title：International journal of oncology

authors： Michaelidou K,Tzovaras A,Missitzis I,Ardavanis A,Scorilas A

更新日期：2013-05-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:We have previously investigated the possibility of using hypericin as a diagnostic tool for the fluorescence detection of flat bladder carcinoma. In these clinical studies, it was shown that following intravesical application in humans, hypericin becomes selectively localized in transitional papillary carcinoma and ca...

journal_title：International journal of oncology

authors： Kamuhabwa AA,Roskams T,Baert L,De Witte PA

更新日期：2003-04-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common solid neoplasm of adult kidney, and the major treatment for metastatic RCC (mRCC) is molecular targeted therapy. Sorafenib, as a multi-targeted tyrosine kinase inhibitor (TKI), has significantly improved clinical outcomes of mRCC patients. However, complete or long-term re...

journal_title：International journal of oncology

authors： Zhang P,Xing Z,Li X,Song Y,Zhao J,Xiao Y,Xing Y

更新日期：2016-04-01 00:00:00

abstract：:Frizzled (FZD) genes encode receptors for WNTs, which play key roles in carcinogenesis and embryogenesis. We have previously cloned the FZD10 gene, and demonstrated up-regulation of FZD10 mRNA in the cervical cancer cell line HeLa S3, gastric cancer cell lines TMK1 and MKN74, and 4 cases out of 10 cases of primary gas...

journal_title：International journal of oncology

authors： Saitoh T,Mine T,Katoh M

更新日期：2002-01-01 00:00:00

abstract：:To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...

journal_title：International journal of oncology

authors： Frankfurt O,Seckinger D,Sugarbaker E

更新日期：1994-02-01 00:00:00

abstract：:Claudin 6 (CLDN6), a member of tight junction protein claudin (CLDN) family, inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. However, these molecular mechanisms of CLDN6-induced apoptosis remain largely elusive. We previously found that restoration of human CLDN6 gene expression was correlat...

journal_title：International journal of oncology

authors： Guo Y,Lin D,Zhang M,Zhang X,Li Y,Yang R,Lu Y,Jin X,Yang M,Wang M,Zhao S,Quan C

更新日期：2016-06-01 00:00:00

abstract：:Seventy-two archival specimens of advanced gastric adenocarcinoma were analyzed by fluorescence in situ hybridization and immunohistochemistry for HER2 gene status. Gene amplification and concomitant protein overexpression were detected in 15.2% of cases. Intratumor topographical variability of HER2 amplification was ...

journal_title：International journal of oncology

authors： Risio M,De Rosa G,Sarotto I,Casorzo L,Capussotti L,Torchio B,Aglietta M,Chiecchio L

更新日期：2003-11-01 00:00:00

abstract：:The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at ...

journal_title：International journal of oncology

authors： Denzinger S,Stoehr R,Schwarz S,Eichenseher N,Brockhoff G,Obermann EC,Knuechel R,Blaszyk H,Hartmann A,Wild PJ

更新日期：2007-10-01 00:00:00

abstract：:Acquired drug resistance to chemotherapy is a major problem in the treatment of cancer. After primary surgical intervention, followed by chemotherapy treatments, the majority of patients develop disease recurrence. This is due to tumor cell heterogeneity and genetic instability. In contrast to tumor cells, proliferati...

journal_title：International journal of oncology

authors： Benouchan M,Colombo BM

更新日期：2005-08-01 00:00:00

abstract：:High levels of mitotic progression-associated PLK1 and stress-associated HSF1 have been observed in various human cancers. In the present study, we investigated the effects of PLK1 and HSF1 knockdown on the proliferation of oral cancer cells using small interfering RNA. In human oral squamous cell carcinoma (SCC) tiss...

journal_title：International journal of oncology

authors： Kim SA,Kwon SM,Yoon JH,Ahn SG

更新日期：2010-04-01 00:00:00

abstract：:High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA ...

journal_title：International journal of oncology

authors： Schwarm FP,Uhle F,Schänzer A,Acker T,Stein M,Reinges MH,Weischer C,Weigand MA,Uhl E,Kolodziej MA

更新日期：2016-04-01 00:00:00

abstract：:Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at...

journal_title：International journal of oncology

authors： Kisu I,Banno K,Kobayashi Y,Ono A,Masuda K,Ueki A,Nomura H,Hirasawa A,Abe T,Kouyama K,Susumu N,Aoki D

更新日期：2011-11-01 00:00:00

abstract：:The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of our knowledge, there are only...

journal_title：International journal of oncology

authors： Xu H,He Y,Ma J,Zhao Y,Liu Y,Sun L,Su J

更新日期：2020-09-01 00:00:00

abstract：:Paclitaxel (taxol) has been used for the treatment of various human tumors and is an exceedingly efficient chemotherapy agent against esophageal cancer. However, the precise molecular mechanisms of paclitaxel effects on human esophageal adenocarcinoma cells are not well understood. MTT assay and cell cycle analysis we...

journal_title：International journal of oncology

authors： Kim SJ,Chung MJ,Kim JS,Kim B,Park WH,Kim SH,Kim SZ,Lee JS,Kim SM

更新日期：2011-12-01 00:00:00

abstract：:The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative ...

journal_title：International journal of oncology

authors： Bai XZ,Masters JR,O'Donoghue N,Kirby R,Pan LX,Young M,Stafford M,Parkinson MC

更新日期：1999-04-01 00:00:00

abstract：:The retinoic acid receptor (RAR) beta gene is located in a region on chromosome 3p, which is frequently deleted in renal cell carcinoma. Since retinoic acid (RA) can inhibit cell proliferation and tumor formation, loss of RAR beta might contribute to oncogenesis of the kidney. This prompted us to examine RAR beta expr...

journal_title：International journal of oncology

authors： Vanderleede B,Opdenoordt T,Vandenbrink C,Ebert T,Vandersaag P

更新日期：1995-02-01 00:00:00

abstract：:The DNA topoisomerase I inhibitor beta-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of beta-lapachone on the growth of human prostate epithelial cells. Upon treatment with beta-lapachon...

journal_title：International journal of oncology

authors： Choi YH,Kim MJ,Lee SY,Lee YN,Chi GY,Eom HS,Kim ND,Choi BT

更新日期：2002-12-01 00:00:00

abstract：:We have previously isolated a drug-resistant, [PC3(R)], variant of human prostate PC3 cell line, which showed significant resistance (>10-fold) to adriamycin. No known mechanisms of drug resistance were found; however, resistant cells expressed more bcl2, c-myc, and ms oncogenes compared to the sensitive cells. In thi...

journal_title：International journal of oncology

authors： Sinha B,Song K

更新日期：1997-10-01 00:00:00

abstract：:Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‑TKI), is widely applied as a first‑line treatment for non‑small cell lung cancer (NSCLC) and greatly improves the clinical outcomes of patients. However, acquired resistance to EGFR‑TKIs remains a major clinical challenge. Here, we identifi...

journal_title：International journal of oncology

authors： Cheng L,Gou L,Wei T,Zhang J

更新日期：2020-09-01 00:00:00

abstract：:Curcumin shows growth-inhibition against tumor cells through multi-target mechanisms. Nevertheless, the poor stability and pharmacokinetics considerably limit its clinical functions. Increased effort has been put into the chemical alteration of curcumin to find potential analogues with improved bioavailability and ant...

journal_title：International journal of oncology

authors： Pan Y,Liu G,Xiao J,Su B,Zhou F,Wei Y

更新日期：2016-05-01 00:00:00

abstract：:In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to...

journal_title：International journal of oncology

authors： Gupta S

更新日期：2003-01-01 00:00:00