Regulatory role of nucleophosmin during the differentiation of human liver cancer cells.

abstract：:Recent studies have reported that chemically synthesized small activating RNA (saRNA) targeting the promoter regions of a gene can activate its expression in different cell lines. This technique can be a powerful therapeutic method for diseases caused by complete inactivation or reduced expression of specific genes. E...

journal_title：International journal of oncology

authors： Wu Z,Li Y,Li Z,Liu Z,Qin Z,Li X,Ye Y,Bu L,Lin B,Wang Z,Jia G,Chen G

更新日期：2016-10-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00

abstract：:5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity induced by 5-FU alon...

journal_title：International journal of oncology

authors： Lamberti M,Porto S,Zappavigna S,Stiuso P,Tirino V,Desiderio V,Mele L,Caraglia M

更新日期：2015-05-01 00:00:00

abstract：:Upregulation of nuclear factor-κB (NF-κB) in colorectal carcinoma (CRC) accelerates tumor growth, whereas, irinotecan (CPT-11)-induced NF-κB activation reduces chemosensitivity and weakens the anti-colorectal cancer function itself, while proteasome inhibitors can inhibit NF-κB and improve the effect of chemotherapy. ...

journal_title：International journal of oncology

authors： Tang W,Su G,Li J,Liao J,Chen S,Huang C,Liu F,Chen Q,Ye Y

更新日期：2014-09-01 00:00:00

abstract：:Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (C...

journal_title：International journal of oncology

authors： Yu JH,Zheng JB,Qi J,Yang K,Wu YH,Wang K,Wang CB,Sun XJ

更新日期：2019-03-01 00:00:00

abstract：:A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared with culture in 10% serum. Addition of linoleic acid (LA; 18:2, n-6) to low serum medium partially restored nor...

journal_title：International journal of oncology

authors： Tillotson J,Darzynkiewicz Z,Cohen L,Ronai Z

更新日期：1993-07-01 00:00:00

abstract：:Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...

journal_title：International journal of oncology

authors： Gazitt Y,Lavia M,Erdos G

更新日期：1993-09-01 00:00:00

abstract：:Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer. Anti-cancer effects are due to the virus ability: i) to replicate in and kill tumor cells, leading finally to their selective elimination; and ...

journal_title：International journal of oncology

authors： Fournier P,Wilden H,Schirrmacher V

更新日期：2012-01-01 00:00:00

abstract：:Regulation of cytoplasmic p21CIP/WAF1 (p21) is of great clinical significance in molecular oncology due to its identification as an antiapoptotic factor, a poor survival predictor as well as a drug-resistance inducer. A retrospective study of the immunohistochemical (IHC) profiles of 128 human primary breast cancers s...

journal_title：International journal of oncology

authors： Ping B,He X,Xia W,Lee DF,Wei Y,Yu D,Mills G,Shi D,Hung MC

更新日期：2006-11-01 00:00:00

abstract：:Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor p...

journal_title：International journal of oncology

authors： Shan L,Zhao M,Lu Y,Ning H,Yang S,Song Y,Chai W,Shi X

更新日期：2019-07-01 00:00:00

abstract：:Transcriptional silencing of the DNA repair protein, O6-methylguanine-DNA methyltransferase (MGMT), occurs only in malignant or transformed cell lines, and such MGMT-deficient cells are hypersensitive to chemotherapeutic alkylating agents such as 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide. Previous...

journal_title：International journal of oncology

authors： Danam RP,Howell SR,Remack JS,Brent TP

更新日期：2001-06-01 00:00:00

abstract：:Patients with esophageal carcinoma (ESCA) have a poor prognosis and high mortality rate. Although standard therapies have had effect, there is an urgent requirement to develop novel options, as increasing drug tolerance has been identified in clinical practice. In the present study, differentially expressed genes (DEG...

journal_title：International journal of oncology

authors： Chen YT,Xie JY,Sun Q,Mo WJ

更新日期：2019-01-01 00:00:00

abstract：:Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...

journal_title：International journal of oncology

authors： Konduri S,Lakka SS,Tasiou A,Yanamandra N,Gondi CS,Dinh DH,Olivero WC,Gujrati M,Rao JS

更新日期：2001-09-01 00:00:00

abstract：:The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy woul...

journal_title：International journal of oncology

authors： Pang Y,Liu J,Li X,Zhang Y,Zhang B,Zhang J,Du N,Xu C,Liang R,Ren H,Tang SC,Sun X

更新日期：2017-10-01 00:00:00

abstract：:Cancer antigens RAK-p120, p42, and p25, which exhibit biological, immunological and molecular similarity to the proteins expressed by Human Immunodeficiency Virus 1 (HIV-1), were found in 47 of 47 tested cases of serous adenocarcinoma of the ovary, and 45 of 45 tested cases of squamous carcinoma of the cervix. Normal ...

journal_title：International journal of oncology

authors： Rakowiczszulczynska E,Roszak A,Mackiewicz A,Markowska J,McIntosh D,Karczewska A,Godlewski D,Snyder W,Leary D,Smith M

更新日期：1996-10-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

journal_title：International journal of oncology

authors： Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

更新日期：2016-08-01 00:00:00

abstract：:Pro‑inflammatory (M1) macrophages have key roles in atherogenesis. As β‑glucan has been demonstrated to exert pro‑inflammatory effects, the present study examined whether β‑glucan exerts atherogenic effects via converting macrophages into M1 phenotype. The results from reverse transcription‑quantitative polymerase cha...

journal_title：International journal of oncology

authors： Li X,Luo H,Ye Y,Chen X,Zou Y,Duan J,Xiang D

更新日期：2019-01-01 00:00:00

abstract：:This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, which was originally gefitinib...

journal_title：International journal of oncology

authors： Terai H,Soejima K,Yasuda H,Sato T,Naoki K,Ikemura S,Arai D,Ohgino K,Ishioka K,Hamamoto J,Kanai Y,Betsuyaku T

更新日期：2015-01-01 00:00:00

abstract：:CXC chemokines have a major influence on the angiogenesis, growth and metastatic potential of pancreatic ductal adenocarcinoma. CXCL16 is a unique transmembrane CXC chemokine, which is shed by members of the disintegrins and metalloproteases (ADAMs), in particular by ADAM10 and ADAM17. In our study, we evaluated expre...

journal_title：International journal of oncology

authors： Wente MN,Gaida MM,Mayer C,Michalski CW,Haag N,Giese T,Felix K,Bergmann F,Giese NA,Friess H

更新日期：2008-08-01 00:00:00

abstract：:Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease. Polysaccharide-K® (PSK), an extract of the mushroom Trametes versicolor, has immunomodulatory and tumor suppressive a...

journal_title：International journal of oncology

authors： Wenner CA,Martzen MR,Lu H,Verneris MR,Wang H,Slaton JW

更新日期：2012-04-01 00:00:00

abstract：:Ganoderma lucidum (Curt.:Fr.) P. Karst, a medicinal fungus, has been widely used in Asian countries for centuries to prevent or treat a variety of diseases, including cancer. However, the mechanisms responsible for the effects of G. lucidum on cancer cells remain to be elucidated. We have previously shown that ethyl a...

journal_title：International journal of oncology

authors： Zaidman BZ,Wasser SP,Nevo E,Mahajna J

更新日期：2007-10-01 00:00:00

abstract：:Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‑TKI), is widely applied as a first‑line treatment for non‑small cell lung cancer (NSCLC) and greatly improves the clinical outcomes of patients. However, acquired resistance to EGFR‑TKIs remains a major clinical challenge. Here, we identifi...

journal_title：International journal of oncology

authors： Cheng L,Gou L,Wei T,Zhang J

更新日期：2020-09-01 00:00:00

abstract：:Resistance may be classified as active (or competitive) (due to excess amount of a factor) vs passive (or non-competitive) (due to a deficiency of a factor). Passive resistance may be important in human solid tumors. In passive resistance, the dose-response curve may be shallow, or may flatten at a relatively low dose...

journal_title：International journal of oncology

authors： Stewart DJ,Goel R,Gertler SZ,Huan S,Tomiak EM,Yau J,Cripps C,Evans WK

更新日期：1999-10-01 00:00:00

abstract：:The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers. However, the function and molecular mechanisms of CXCR7 in human colorectal cancer (CRC) are still undefined. In the present study, sixty-eight cases of CRC tissues and corresponding adjac...

journal_title：International journal of oncology

authors： Li XX,Zheng HT,Huang LY,Shi DB,Peng JJ,Liang L,Cai SJ

更新日期：2014-10-01 00:00:00

abstract：:High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA ...

journal_title：International journal of oncology

authors： Schwarm FP,Uhle F,Schänzer A,Acker T,Stein M,Reinges MH,Weischer C,Weigand MA,Uhl E,Kolodziej MA

更新日期：2016-04-01 00:00:00

abstract：:p57KIP2, the second class of KIP family protein, is one of the negative regulators of the cell cycle. To elucidate the role of p57KIP2 in colorectal normal mucosa and cancer, we examined the expression of p57KIP2 protein in 110 pairs of colorectal non-tumor and cancer tissues. Immunohistochemical analysis showed that ...

journal_title：International journal of oncology

authors： Noura S,Yamamoto H,Sekimoto M,Takemasa I,Miyake Y,Ikenaga M,Matsuura N,Monden M

更新日期：2001-07-01 00:00:00

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:We investigated the clinical significance of the expression levels of matrix metalloproteinase 9 (MMP-9) in renal cell carcinoma (RCC). In addition, we validated the efficacy of pyrrole imidazole polyamide (PIP) targeting MMP-9 on inhibiting proliferation and invasion of RCC. We evaluated the expression levels of MMP-...

journal_title：International journal of oncology

authors： Sato A,Nagase H,Obinata D,Fujiwara K,Fukuda N,Soma M,Yamaguchi K,Kawata N,Takahashi S

更新日期：2013-11-01 00:00:00

abstract：:MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...

journal_title：International journal of oncology

authors： Kim EA,Kim TG,Sung EG,Song IH,Kim JY,Doh KO,Lee TJ

更新日期：2017-03-01 00:00:00

abstract：:The tumour suppressor gene hypermethylated in cancer 1 (HIC1) is a transcriptional repressor, which functionally cooperates with p53. Loss of HIC1 function is associated with the development of various tumor entities. The aim of this study was to elucidate the relevance of CpG islan...

journal_title：International journal of oncology

authors： Eggers H,Steffens S,Grosshennig A,Becker JU,Hennenlotter J,Stenzl A,Merseburger AS,Kuczyk MA,Serth J

更新日期：2012-05-01 00:00:00