Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma.

abstract：:Cancer stem cells (CSCs) are known to influence chemoresistance, survival, relapse and metastasis. Aldehyde dehydrogenase (ALDH) functions as an epithelial CSC marker. In the present study, we investigated the involvement of ALDH in gastric CSC maintenance, chemoresistance and survival. Following screening for eight c...

journal_title：International journal of oncology

authors： Nishikawa S,Konno M,Hamabe A,Hasegawa S,Kano Y,Ohta K,Fukusumi T,Sakai D,Kudo T,Haraguchi N,Satoh T,Takiguchi S,Mori M,Doki Y,Ishii H

更新日期：2013-04-01 00:00:00

abstract：:Eukaryotic initiation factor 3c (eIF3C) is involved in the initiation of protein translation. Aberrant eIF3C expression has been reported in different types of human cancer. The present study aimed to assess the role of eIF3C in the malignant behavior of renal cell carcinoma in vitro and in vivo. eIF3C expression was ...

journal_title：International journal of oncology

authors： Fan M,Wang K,Wei X,Yao H,Chen Z,He X

更新日期：2019-12-01 00:00:00

abstract：:CD34 is commonly used as an endothelial cell marker of tumor vessels. However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed endothelial cells. In this study,...

journal_title：International journal of oncology

authors： Teranishi N,Naito Z,Ishiwata T,Tanaka N,Furukawa K,Seya T,Shinji S,Tajiri T

更新日期：2007-03-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:Despite recent advances in targeted therapies and immunotherapies metastatic melanoma remains only rarely curable. The objective of the present study was to identify novel therapeutic targets for metastatic melanoma. A library of 160 well-characterised and potent protein kinase inhibitors was screened in the BRAF muta...

journal_title：International journal of oncology

authors： Mahgoub T,Eustace AJ,Collins DM,Walsh N,O'Donovan N,Crown J

更新日期：2015-09-01 00:00:00

abstract：:This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...

journal_title：International journal of oncology

authors： Van den Neste E,Cardoen S,Offner F,Bontemps F

更新日期：2005-10-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is a low-grade lymphoid malignancy incurable with conventional modalities of chemotherapy. We aimed to examine the proapoptotic effects of a novel proteasome inhibitor, N,N'-di-(m-methylphenyi)-3,6- dimethyl-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboamide (ZGDH...

journal_title：International journal of oncology

authors： Qiu LN,Zhou YL,Wang ZN,Huang Q,Hu WX

更新日期：2012-08-01 00:00:00

abstract：:Approval of the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab by the FDA in 2004 reflected the success of this vascular targeting strategy in extending survival in patients with advanced cancers. However, consistent with previous reports that experimental tumors can grow or recur during VEGF bloc...

journal_title：International journal of oncology

authors： Huang J,Bae JO,Tsai JP,Kadenhe-Chiweshe A,Papa J,Lee A,Zeng S,Kornfeld ZN,Ullner P,Zaghloul N,Ioffe E,Nandor S,Burova E,Holash J,Thurston G,Rudge J,Yancopoulos GD,Yamashiro DJ,Kandel JJ

更新日期：2009-01-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted therapies due to lack of related receptors. These patients overexpress the epidermal growth factor receptor (EGFR), but are resistant to tyrosine kinase inhibitors (TKIs) and anti-EGFR therapies. Mechanisms suggested for...

journal_title：International journal of oncology

authors： Bellizzi A,Greco MR,Rubino R,Paradiso A,Forciniti S,Zeeberg K,Cardone RA,Reshkin SJ

更新日期：2015-03-01 00:00:00

abstract：:E-cadherins are homophilic adhesion molecules the expression of which is tightly linked to the invasiveness and the differentiated state of the cells. E-cadherin expression seems also inversely related to the expression of vimentin, an intermediate filament implicated in the metastatic potential of some cells. In brea...

journal_title：International journal of oncology

authors： Vandewalle B,Revillion F,Doutrelant P,Granier A,Lefebvre J

更新日期：1994-01-01 00:00:00

abstract：:Most malignant tumors have a defect in the Rb pathway that allows them to proliferate autonomously, unrestricted by the availability of mitogens and growth factors. This defect preconditions tumor cells to be less sensitive to inhibitors of growth factor receptors and/or signal transduction pathways that arrest normal...

journal_title：International journal of oncology

authors： Du L,Smolewski P,Bedner E,Traganos F,Darzynkiewicz Z

更新日期：2001-10-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) can stimulate tumor progression by both direct and indirect mechanisms. However, its influence on cell proliferation is still unclear. The present study characterized expression of subtypes of PGE2 receptors in oral squamous cell carcinomas, while also investigating the effects of EP3 and EP4 s...

journal_title：International journal of oncology

authors： Hoshikawa H,Goto R,Mori T,Mitani T,Mori N

更新日期：2009-03-01 00:00:00

abstract：:Loss of heterozygosity (LOH) or allelic deletion at various loci has been reported in the majority of human tumors. The frequently deleted targets are believed to be tumor suppressor genes. Recent studies have identified the APC and MCC genes at 5q21, as putative tumor suppressor genes. The APC and MCC genes have been...

journal_title：International journal of oncology

authors： Gao X,Zacharek A,Grignon D,Liu H,Sakr W,Porter A,Chen Y,Honn K

更新日期：1995-01-01 00:00:00

abstract：:As epidemiological data suggest ultraviolet (UV) radiation to be the major environmental factor for the development of melanoma, we screened this malignancy for UV-specific C right curved arrow T and CC right curved arrow TT DNA mutations as described in squamous and basal cell carcinomas of the skin. Mitochondrial (m...

journal_title：International journal of oncology

authors： Deichmann M,Kahle B,Benner A,Thome M,Helmke B,Näher H

更新日期：2004-01-01 00:00:00

abstract：:Polo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role in colorectal cancer (CRC) development remains unknown. The present study demonstrated that PLK4 protein expression was upregulated in CRC tissues compared with in normal tissues thr...

journal_title：International journal of oncology

authors： Liao Z,Zhang H,Fan P,Huang Q,Dong K,Qi Y,Song J,Chen L,Liang H,Chen X,Zhang Z,Zhang B

更新日期：2019-02-01 00:00:00

abstract：:Glioblastoma is the most malignant type of primary brain tumor that has been shown to contain a small population of cancer stem cells. Recent studies have suggested that cancer stem cells cause tumor recurrence based on their resistance to radiotherapy and chemotherapy. Although the highly invasive nature of glioblast...

journal_title：International journal of oncology

authors： Inoue A,Takahashi H,Harada H,Kohno S,Ohue S,Kobayashi K,Yano H,Tanaka J,Ohnishi T

更新日期：2010-11-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a malignant tumour of skeletal muscle origin which includes two major histological subtypes: alveolar rhabdomyosarcoma (ARMS), the more aggressive, and embryonal rhabdomyosarcoma (ERMS). In order to establish whether the higher metastatic potential of ARMS cells may depend on differential exp...

journal_title：International journal of oncology

authors： Onisto M,Slongo ML,Gregnanin L,Gastaldi T,Carli M,Rosolen A

更新日期：2005-09-01 00:00:00

abstract：:Hepatocellular carcinoma is the most frequent liver cancer and hepatitis B virus is included among the risk factors for the development of this type of neoplasia. Direct detection of this virus is difficult due to the lack of a simple tissue culture system for growing the virus. Amplification of HBV nucleic acid seque...

journal_title：International journal of oncology

authors： Haliassos A,Arvanitis D,Parliaras J,Spandidos D

更新日期：1992-07-01 00:00:00

abstract：:Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and...

journal_title：International journal of oncology

authors： Li JQ,Xu BJ,Shakhtour B,Deane N,Merchant N,Heslin MJ,Washington K,Coffey RJ,Beauchamp RD,Shyr Y,Billheimer D

更新日期：2007-07-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...

journal_title：International journal of oncology

authors： Yin F,Liu X,Li D,Wang Q,Zhang W,Li L

更新日期：2013-04-01 00:00:00

abstract：:Autologous bone marrow transplantation (ABMT) often produces durable remission in patients with intermediate-high grade non-Hodgkin's lymphoma (NHL). We present a retrospective review of 32 eligible newly diagnosed patients with NHL treated with conventional induction chemotherapy followed by ABMT consolidation therap...

journal_title：International journal of oncology

authors： Montuoro A,Lalle M,Ingletto D

更新日期：2000-10-01 00:00:00

abstract：:Photodynamic therapy (PDT) following lung-sparing extended pleurectomy for malignant pleural mesothelioma (MPM) has been investigated as a potential means to kill residual microscopic cells. High expression levels of folate receptor 1 (FOLR1) have been reported in MPM; therefore, targeting FOLR1 has been considered a ...

journal_title：International journal of oncology

authors： Kato T,Jin CS,Lee D,Ujiie H,Fujino K,Hu HP,Wada H,Wu L,Chen J,Weersink RA,Kanno H,Hatanaka Y,Hatanaka KC,Kaga K,Matsui Y,Matsuno Y,De Perrot M,Wilson BC,Zheng G,Yasufuku K

更新日期：2018-11-01 00:00:00

abstract：:The homeobox transcription factor orthodenticle homeobox 2 (OTX2) plays a critical role in very early neurogenesis, but can become oncogenic when aberrantly expressed later in life. We previously discovered its novel oncogenic role in the malignant childhood brain tumor medulloblastoma and hypothesize an oncogenic rol...

journal_title：International journal of oncology

authors： Li J,Di C,Jing J,Di Q,Nakhla J,Adamson DC

更新日期：2015-11-01 00:00:00

abstract：:Percutaneous nephrostomy (PN) will rapidly correct renal failure due to ureteral obstruction. Complications of the procedure are few and the procedure can be quickly accomplished on an outpatient basis using local anesthesia. A retrospective review of fifty patients who underwent PN led to derivation of a formula whic...

journal_title：International journal of oncology

authors： McKenna B,Chalas E,Ferretti J,Rothpearl A,Mann W

更新日期：1994-04-01 00:00:00

abstract：:Curcumin (diferulolylmethane), an active ingredient derived from the rhizome of the plant Curcuma longa, has anticancer activity in vitro and in vivo. Although curcumin possesses chemopreventive properties against several types of cancer, the molecular mechanisms by which it inhibits cell growth and induces apoptosis ...

journal_title：International journal of oncology

authors： Shankar S,Srivastava RK

更新日期：2007-04-01 00:00:00

abstract：:The p53-induced wig-1 gene encodes an unusual nuclear zinc finger protein with high sequence similarity between human, rat and mouse. Wig-1 belongs to a group of proteins with widely spaced zinc fingers that bind double stranded (ds) RNA. We show here that wig-1 is present in Gallus gallus (chicken), Silurana tropical...

journal_title：International journal of oncology

authors： Hellborg F,Wiman KG

更新日期：2004-06-01 00:00:00

abstract：:CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...

journal_title：International journal of oncology

authors： Sato K,Dang NH

更新日期：2003-03-01 00:00:00