High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer.

abstract：:Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...

journal_title：International journal of oncology

authors： Michaelidou K,Tzovaras A,Missitzis I,Ardavanis A,Scorilas A

更新日期：2013-05-01 00:00:00

abstract：:After the publication of the article, the authors noted that they had made the following errors. In Fig. 5B, total PDK1 is incorrect in the published paper. The corrected version of Fig. 5B is shown below. Also in Fig. 6B, the DMSO-treated group and the brassinin (400 µM)-treated group are incorrect, and the corrected...

journal_title：International journal of oncology

authors： Izutani Y,Yogosawa S,Sowa Y,Sakai T

更新日期：2016-03-01 00:00:00

abstract：:Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...

journal_title：International journal of oncology

authors： Uchiyama T,Takahashi H,Endo H,Sugiyama M,Sakai E,Hosono K,Nagashima Y,Inayama Y,Wada K,Hippo Y,Nakajima A

更新日期：2011-10-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hal...

journal_title：International journal of oncology

authors： Pak SH,Joung YH,Park JH,Lim EJ,Darvin P,Na YM,Hong DY,Lee B,Hwang TS,Park T,Ye SK,Moon ES,Cho BW,Park KD,Lee HK,Chung IM,Yang YM

更新日期：2012-07-01 00:00:00

abstract：:The inhibitor of oxidative phosphorylation, 2,4-dinitrophenol (DNP), abrogates etoposide cytotoxicity in murine leukemia L1210 cells without affecting the quantity of drug-induced DNA lesions. Cell cycle arrest and events associated with cell death were followed in etoposide treated L1210 cells under conditions in whi...

journal_title：International journal of oncology

authors： Lock R,Thompson B,Stribinskiene L

更新日期：1996-02-01 00:00:00

abstract：:Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 part...

journal_title：International journal of oncology

authors： Tomirotti M,Bernardo G,Epifani C,Biasioli R,Franchi R,Mensi F,Carnaghi P,Schieppati G,Scanni A

更新日期：1993-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) represent a class of small non-coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been described for several human malignancies. Herein, we show that miR-145 is down-regulated in human cancer cell line MCF-7 when compared...

journal_title：International journal of oncology

authors： Wang S,Bian C,Yang Z,Bo Y,Li J,Zeng L,Zhou H,Zhao RC

更新日期：2009-05-01 00:00:00

abstract：:Oxygen tension measurements were made in three tumors: (i) the murine FSaII fibrosarcoma, (ii) the rat 9L gliosarcoma and (iii) the rat 13672 mammary adenocarcinoma using a pO2 histograph. Tumor oxygenation measurements were made while the animals breathed air or breathed carbogen (95% oxygen/5% carbon dioxide). Pento...

journal_title：International journal of oncology

authors： Teicher B,Sotomayor E,Robinson M,Dupuis N,Schwartz G,Frei E

更新日期：1993-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is known to be resistant to chemotherapy. Survivin, a member of the inhibitor of apoptosis proteins, is overexpressed in most cancers but is absent in most normal adult tissue. The aim of this study was to investigate whether expression of survivin contributes to resistance to cisplatin-...

journal_title：International journal of oncology

authors： Asechi H,Hatano E,Nitta T,Tada M,Iwaisako K,Tamaki N,Nagata H,Narita M,Yanagida A,Ikai I,Uemoto S

更新日期：2010-07-01 00:00:00

abstract：:Wilms' tumor is one of the most common malignant tumors of the abdomen in children. However, there is currently no recognized specific biomarker for the clinical diagnosis and prognosis of this tumor. Lipid metabolism is involved in membrane synthesis and oxidation in tumor cells. This process plays an important role ...

journal_title：International journal of oncology

authors： Wang X,Du G,Wu Y,Zhang Y,Guo F,Liu W,Wu R

更新日期：2020-02-01 00:00:00

abstract：:The molecular mechanism playing a role in the development of benign prostate hypertrophy (BPH) and prostate cancer (PC) is not well defined. We performed microarray analysis to assess the gene expression change in BPH and PC, and performed network analysis. Normal prostate, BPH and PC tissues were obtained from patien...

journal_title：International journal of oncology

authors： Endo T,Uzawa K,Suzuki H,Tanzawa H,Ichikawa T

更新日期：2009-09-01 00:00:00

abstract：:We examined the relationships among nuclear DNA content, tumor origin, nuclear size, and prognosis in squamous cell lung cancer. Central tumors had significantly higher DNA aneuploidy (83%, p<0.01) and DNA indices (1.65+/-0.40, p<0.01) than did peripheral tumors (40%, 1.29+/-0.37, respectively). All six women in the s...

journal_title：International journal of oncology

authors： Miyamoto H,Isobe H,Akita H,Ishiguro A,Endo T,Inoue S,Kawakami Y

更新日期：1992-08-01 00:00:00

abstract：:CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...

journal_title：International journal of oncology

authors： Sato K,Dang NH

更新日期：2003-03-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...

journal_title：International journal of oncology

authors： Jiao F,Hu H,Yuan C,Jin Z,Guo Z,Wang L,Wang L

更新日期：2014-10-01 00:00:00

abstract：:Antisense oligonucleotides have been investigated as anticancer agents administered alone or in combination with conventional chemotherapeutics. In the present study, we demonstrated synergistic effects between anti-MDM2 antisense oligonucleotides and the clinically used anticancer agent irinotecan, using nude mouse m...

journal_title：International journal of oncology

authors： Wang H,Wang S,Nan L,Yu D,Agrawal S,Zhang R

更新日期：2002-04-01 00:00:00

abstract：:Highly aggressive murine B16 melanoma was engineered to secrete IFN-alpha constitutively. Cells expressing IFN-alpha were injected into syngeneic C57BL/6 mice and the mice were monitored for tumor development. Secretion of IFN-alpha by B16 melanoma cells completely abrogated their tumorigenicity in syngeneic mice. LFN...

journal_title：International journal of oncology

authors： Sarkar S,Flores I,Ron Y,Derosa C,Ozzello L,Pestka S

更新日期：1995-07-01 00:00:00

abstract：:Of 108 Wistar/Ma rats perinatally injected with Snyder-Theilen feline sarcoma virus, 75 developed tumors within 60 days (group A), and 25 after more than 117 days (group B). Metastases were detected in 59.1% and 11.8% in group A and B respectively. Antibody to v-fes gene product was found to occur before tumor develop...

journal_title：International journal of oncology

authors： Lu S,Miyauchi M,Maruyama K

更新日期：1997-03-01 00:00:00

abstract：:It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferati...

journal_title：International journal of oncology

authors： Zhang C,Xu W,Pan W,Wang N,Li G,Fan X,Xu X,Shen S,Das UN

更新日期：2013-05-01 00:00:00

abstract：:Benzyl isothiocyanate (BITC) is known for its pharmacological properties against malignant neoplasm, including bladder cancer (BC). The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR‑99a‑5p in BITC‑treated BC cells. A quantitative polymerase chain reaction (...

journal_title：International journal of oncology

authors： Lin JF,Tsai TF,Lin YC,Chen HE,Chou KY,Hwang TI

更新日期：2019-06-01 00:00:00

abstract：:We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal gastric mucosa. The production of HSP90 increased in eight gastric carcinoma cell lines. Gelsolin content was down-regulated in seven gastric carcinoma cell lines. Furthermore, the production of GST-pi increased in a poorly dif...

journal_title：International journal of oncology

authors： Moriya S,Yanagihara K,Fujita H,Kuzumaki N

更新日期：1994-12-01 00:00:00

abstract：:The effects of different substrate stiffness were investigated on epithelial-mesenchymal transition (EMT) of cervical cancer cell lines and the role of miR-106b and its target protein DAB2 therein. Cervical cancer cell lines HeLa and SiHa were cultured on artificial substrates with different stiffness prepared using d...

journal_title：International journal of oncology

authors： Piao J,You K,Guo Y,Zhang Y,Li Z,Geng L

更新日期：2017-06-01 00:00:00

abstract：:Neuroblastoma is a paediatric solid tumor characterized by recurrent genomic abnormalities of prognostic importance. One of the most commonly observed abnormalities is deletion of the short arm of chromosome 1 and reduced expression of cancer related genes in this chromosomal arm. The long isoform of the retinoblastom...

journal_title：International journal of oncology

authors： Geli J,Kiss N,Kogner P,Larsson C

更新日期：2010-11-01 00:00:00

abstract：:The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative ...

journal_title：International journal of oncology

authors： Bai XZ,Masters JR,O'Donoghue N,Kirby R,Pan LX,Young M,Stafford M,Parkinson MC

更新日期：1999-04-01 00:00:00

abstract：:Structural maintenance of chromosome 1 alpha (SMC1A) gene has been reported to be related to tumor development in some types of human cancers. However, the misregulation of SMC1A and its functions in castration-resistant prostate cancer (CRPC) have not been well understood. In the present study, we found that SMC1A wa...

journal_title：International journal of oncology

authors： Pan XW,Gan SS,Ye JQ,Fan YH,Hong Υ,Chu CM,Gao Y,Li L,Liu X,Chen L,Huang Y,Xu H,Ren JZ,Yin L,Qu FJ,Huang H,Cui XG,Xu DF

更新日期：2016-11-01 00:00:00

abstract：:An endocrine disrupting chemical (EDC) is a global health concern. In this study, we examined the effects of genistein (GEN) on bisphenol A (BPA) or 17β-estradiol (E2)-induced cell growth and gene alterations of BG-1 ovarian cancer cells expressing estrogen receptors (ERs). In an in...

journal_title：International journal of oncology

authors： Hwang KA,Kang NH,Yi BR,Lee HR,Park MA,Choi KC

更新日期：2013-02-01 00:00:00

abstract：:Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypoxia is involved in ...

journal_title：International journal of oncology

authors： Kogita A,Togashi Y,Hayashi H,Sogabe S,Terashima M,De Velasco MA,Sakai K,Fujita Y,Tomida S,Takeyama Y,Okuno K,Nakagawa K,Nishio K

更新日期：2014-10-01 00:00:00

abstract：:Following the publication of this article, an interested reader drew to our attention that Fig. 1C contained an important flaw. The Figure shows a western blot for LCN2, DR4, DR5, and actin, and it was noted that the identical bands shown for actin were also featured in a paper by the same authors published in 2017 [L...

journal_title：International journal of oncology

authors： Kim SL,Min IS,Park YR,Lee ST,Kim SW

更新日期：2019-05-01 00:00:00

abstract：:Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...

journal_title：International journal of oncology

authors： Nowak A,Grzegrzółka J,Kmiecik A,Piotrowska A,Matkowski R,Dzięgiel P

更新日期：2018-02-01 00:00:00