Tumor oxygenation and radiosensitization by pentoxifylline and a perflubron emulsion carbogen breathing.

abstract：:The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated. The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR ex...

journal_title：International journal of oncology

authors： Murati A,Arnoulet C,Lafage-Pochitaloff M,Adélaide J,Derré M,Slama B,Delaval B,Popovici C,Vey N,Xerri L,Mozziconacci MJ,Boulat O,Sainty D,Birnbaum D,Chaffanet M

更新日期：2005-06-01 00:00:00

abstract：:Cytokine production in squamous cell carcinoma (SCC) of the head and neck may directly influence the clinical behavior of this aggressive neoplasm since cytokines act as autocrine/paracrine growth factors, as well as immunomodulators. In the present study, the cytokine profiles of 16 SCCs of the head and neck and matc...

journal_title：International journal of oncology

authors： Sabourin C,Wang Q,Mallery S,Nicholson R,Gopalakrishnan R,Lang J,Schuller D,Stoner G

更新日期：1996-01-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...

journal_title：International journal of oncology

authors： Fan X,Wei J,Xiong H,Liu X,Benichou S,Gao X,Liu L

更新日期：2015-10-01 00:00:00

abstract：:Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many types of cell lines and tissues have demonstrated the presence of SP cells, including colon cancer cell lines. This study aimed to identify cancer stem cells (CSCs) in the SP of the colon cancer cell line SW480. SP c...

journal_title：International journal of oncology

authors： Xiong B,Ma L,Hu X,Zhang C,Cheng Y

更新日期：2014-09-01 00:00:00

abstract：:Specific RE protein species modulated by autocrine TGF alpha are unknown. HCT116 cells transfected with TGF alpha antisense expression vector were compared with control HCT116 NEO for mitogenesis and modulation of high MW (130, 120 kD) and low MW (116, 110, 105 kD) RE species. Nutrients alone (N) induced maximal mitog...

journal_title：International journal of oncology

authors： Dobre C,Ziober B,Humphrey L,Brattain M

更新日期：1996-06-01 00:00:00

abstract：:Meningiomas are benign brain tumors thought to arise by multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cell cycle regulator proto-oncogene cyclin D1 has been implicated in the pathogenesis of several types of cancer. Northern blot analysis revealed expr...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-12-01 00:00:00

abstract：:The overall goal of the present study was to evaluate the chemotherapeutic and cancer‑protective properties of D‑erythro‑sphingosine (sphingosine) and C2‑ceramide using a human breast epithelial cell (HBEC) culture system, which represents multiple‑stages of breast carcinogenesis. The HBEC model includes Type I HBECs ...

journal_title：International journal of oncology

authors： Ahn EH,Yang H,Hsieh CY,Sun W,Chang CC,Schroeder JJ

更新日期：2019-02-01 00:00:00

abstract：:The p16INK4 gene, encoding a cyclin-dependent kinase inhibitor, is frequently methylated in colorectal cancer, and a side-specific methylation frequency was suggested. To clarify the frequency of real loss of tumor suppressor function dependent on anatomical localization, we investigated 43 primary colorectal carcinom...

journal_title：International journal of oncology

authors： Schneider-Stock R,Boltze C,Peters B,Höpfner T,Meyer F,Lippert H,Roessner A

更新日期：2003-10-01 00:00:00

abstract：:The interaction between the colon tumor cell surface and the endothelial cell layer is an important component of tumor intravasation, extravasation, and metastasis. Multiple studies suggest that tumor cells may bind to E-selectin expressed on endothelial cells during these processes. To identify possible E-selectin li...

journal_title：International journal of oncology

authors： Tomlinson J,Wang JL,Barsky SH,Lee MC,Bischoff J,Nguyen M

更新日期：2000-02-01 00:00:00

abstract：:Total body irradiation (TBI), given in low to moderate doses as a single modality, can enhance leukocyte populations and immune modifiers, resulting in slowed tumor progression. The aim of this study was to evaluate natural killer (NK) cell involvement in mediating the antitumor effect of TBI by depleting NK populatio...

journal_title：International journal of oncology

authors： Miller GM,Andres ML,Gridley DS

更新日期：2003-12-01 00:00:00

abstract：:Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects...

journal_title：International journal of oncology

authors： Drago-Ferrante R,Santulli A,Di Fiore R,Giuliano M,Calvaruso G,Tesoriere G,Vento R

更新日期：2008-10-01 00:00:00

abstract：:Although the incidence of brain metastasis in gastric cancer is relatively low, its prevalence may increase with improved therapy and longer survival tumors. The molecular mechanisms underlying brain metastases are not well understood. To gain insight into the mechanism of brain metastasis, we studied differences in m...

journal_title：International journal of oncology

authors： Minn YK,Lee DH,Hyung WJ,Kim JE,Choi J,Yang SH,Song H,Lim BJ,Kim SH

更新日期：2014-12-01 00:00:00

abstract：:We have reported that ONO-4007, a novel synthetic lipid A derivative with low toxic activities, produced large amount of tumor necrosis factor (TNF)-alpha selectively in the tumor tissues and brought about complete cures in about 60% of rats bearing TNF-alpha sensitive KDH-8 cells, which also secreted a large amount o...

journal_title：International journal of oncology

authors： Matsushita K,Kuramitsu Y,Ohiro Y,Kobayashi I,Watanabe T,Kobayashi M,Hosokawa M

更新日期：2003-08-01 00:00:00

abstract：:Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...

journal_title：International journal of oncology

authors： Choi EO,Park C,Hwang HJ,Hong SH,Kim GY,Cho EJ,Kim WJ,Choi YH

更新日期：2016-09-01 00:00:00

abstract：:Over the past few decades, there has been a tremendous increase in cancer biology data and treatment. Cancer research has opened exciting new areas of cellular and molecular biology. Month by month, new genes which regulate the carcinogenesis process are being discovered. The result is an incredible knowledge of cance...

journal_title：International journal of oncology

authors： Kanduc D,Bannasch P,Farber E

更新日期：1999-12-01 00:00:00

abstract：:Although the hematopoietic reconstituting ability of human umbilical cord blood cells (UCBC) is well documented, their antitumor cytotoxic potential has not been well studied. Therefore, UCBC were compared to normal peripheral blood stem cells (PBSC) and bone marrow (BM) stem cell harvests for cytomorphology, antitumo...

journal_title：International journal of oncology

authors： Joshi SS,Babushkina-Patz NN,Verbik DJ,Gross TG,Tarantolo SR,Kuszynski CA,Pirruccello SJ,Bishop MR,Kessinger A

更新日期：1998-10-01 00:00:00

abstract：:Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...

journal_title：International journal of oncology

authors： Umene K,Yanokura M,Banno K,Irie H,Adachi M,Iida M,Nakamura K,Nogami Y,Masuda K,Kobayashi Y,Tominaga E,Aoki D

更新日期：2015-04-01 00:00:00

abstract：:Surfactant proteins play important roles in lung surfactant function and innate immunity. The DNA methylation state of 11 CpG sites of surfactant protein (SP)-A1, -B, -C, and -D was determined using universal bead arrays. A total of 90 cancerous and non-cancerous tissues from 23 patients with adenocarcinoma and 22 wit...

journal_title：International journal of oncology

authors： Lin Z,Thomas NJ,Bibikova M,Seifart C,Wang Y,Guo X,Wang G,Vollmer E,Goldmann T,Garcia EW,Zhou L,Fan JB,Floros J

更新日期：2007-07-01 00:00:00

abstract：:The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy woul...

journal_title：International journal of oncology

authors： Pang Y,Liu J,Li X,Zhang Y,Zhang B,Zhang J,Du N,Xu C,Liang R,Ren H,Tang SC,Sun X

更新日期：2017-10-01 00:00:00

abstract：:A chromosomal break indicates a double-stranded DNA break of the chromatin fiber. Cytogenetic observations can enumerate chromosome breaks but cannot detect single-stranded DNA breaks (nicks). When a high frequency of chromosomal breaks occurs in a cell population, whether spontaneously occurred or mutagen induced, a ...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Liang J

更新日期：1993-06-01 00:00:00

abstract：:A promising family of anticancer agents, the camptothecins, is noted for their ability to induce apoptosis specifically in malignant cells. However, a major obstacle for successful cancer treatment by these and other chemotherapeutic agents is the intrinsic or acquired resistance to drug treatment. Resistance to 9NC6,...

journal_title：International journal of oncology

authors： Chatterjee D,Goldman M,Braastad CD,Darnowski J,Wyche JH,Pantazis P,Goodglick L

更新日期：2004-08-01 00:00:00

abstract：:Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...

journal_title：International journal of oncology

authors： Ratajczak-Wielgomas K,Grzegrzolka J,Piotrowska A,Matkowski R,Wojnar A,Rys J,Ugorski M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this devastating disease. In melanoma, both the Ras/Raf/MEK/ERK (MAPK) a...

journal_title：International journal of oncology

authors： Russo A,Ficili B,Candido S,Pezzino FM,Guarneri C,Biondi A,Travali S,McCubrey JA,Spandidos DA,Libra M

更新日期：2014-08-01 00:00:00

abstract：:Tumor necrosis factor‑associated apoptosis‑inducing ligand (TRAIL) is considered to be a potential therapeutic target for various types of cancer. However, colon cancer is difficult to treat due to its resistance to TRAIL. Therefore, various trials have been conducted to overcome TRAIL resistance in colon cancer. The ...

journal_title：International journal of oncology

authors： Kim B,Seo JH,Lee KY,Park B

更新日期：2020-03-01 00:00:00

abstract：:Enhanced Notch signaling contributes to uncontrolled cell growth and cell death resistance in cancer. Here, we demonstrate that in colorectal carcinoma cells the Notch1-dependent activation of cell cycle and proliferation is mediated by repression of the cyclin-dependent kinase inhibitor (CDKI) p27. The half-life of p...

journal_title：International journal of oncology

authors： Hristova NR,Tagscherer KE,Fassl A,Kopitz J,Roth W

更新日期：2013-12-01 00:00:00

abstract：:The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3, can induce differentiation in breast cancer cells; however, it is hypercalcemic in vivo. Therefore, development of non-calcemic analogs of vitamin D has received considerable attention. Recently, we synthesized an analog of vitamin D [1alpha(OH)D5] tha...

journal_title：International journal of oncology

authors： Mehta RR,Bratescu L,Graves JM,Green A,Mehta RG

更新日期：2000-01-01 00:00:00

abstract：:Abnormal activation of signal transducer and activator of transcription 3 (STAT3) serves a pivotal role in oral squamous cell carcinoma (OSCC) tumor cell invasion into normal tissues or distant organs. However the downstream regulatory network of STAT3 signaling remains unclear. The present study aimed to investigate ...

journal_title：International journal of oncology

authors： Wang Y,Guo W,Li Z,Wu Y,Jing C,Ren Y,Zhao M,Kong L,Zhang C,Dong J,Shuang Y,Sun S,Chen J,Wu C,Qiao Y,Qu X,Wang X,Zhang L,Jin R,Zhou X

更新日期：2018-04-01 00:00:00

abstract：:Three separate experiments, designed to minimize the DNA repair process following exposures to mutagens, were performed to determine whether DNA repair capability is the sole factor responsible for differential mutagen sensitivity. These experiments included (i) very short bleomycin pulse treatments (2, 5 and 10 min),...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Brock W,Liang J

更新日期：1995-01-01 00:00:00

abstract：:Seventy-two archival specimens of advanced gastric adenocarcinoma were analyzed by fluorescence in situ hybridization and immunohistochemistry for HER2 gene status. Gene amplification and concomitant protein overexpression were detected in 15.2% of cases. Intratumor topographical variability of HER2 amplification was ...

journal_title：International journal of oncology

authors： Risio M,De Rosa G,Sarotto I,Casorzo L,Capussotti L,Torchio B,Aglietta M,Chiecchio L

更新日期：2003-11-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...

journal_title：International journal of oncology

authors： Chen J,Schmitt A,Giannopoulos K,Chen B,Rojewski M,Döhner H,Bunjes D,Schmitt M

更新日期：2007-11-01 00:00:00