Abstract:
:Autologous bone marrow transplantation (ABMT) often produces durable remission in patients with intermediate-high grade non-Hodgkin's lymphoma (NHL). We present a retrospective review of 32 eligible newly diagnosed patients with NHL treated with conventional induction chemotherapy followed by ABMT consolidation therapy. These patients were treated in our department between 1984-1994 and followed up for 5-172 months with a median time of 82 months. In our patients the status of disease at transplant was 30 complete remissions and 2 partial remissions. All patients received a CBV-like high-dose preparative regimen. At 136 months the probability of disease-free survival (DFS) and overall (OS) is 66% and 70% respectively. Seven patients died from the disease. There was one case of toxicity related death. Our aim was to achieve a status of minimal disease and then consolidate it with high-dose polychemotherapy regimen. This study confirms that a significant number of patients with aggressive responding NHL can achieve prolonged RFS and OS after ABMT. Our data document the importance of long-term follow-up in interpreting the results of ABMT in NHL.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Montuoro A,Lalle M,Ingletto Ddoi
10.3892/ijo.17.4.771keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
771-5issue
4eissn
1019-6439issn
1791-2423journal_volume
17pub_type
杂志文章abstract::Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5140
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journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-11-01 00:00:00
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doi:10.3892/ijo.15.6.1137
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
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更新日期:2015-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3510
更新日期:2016-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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pub_type: 杂志文章
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