Abstract:
:Peptide hormone relaxin produced in normal and cancer prostate cells can stimulate prostate cancer progression. Suppression of relaxin or relaxin receptor RXFP1 expression inhibited prostate cancer both in vitro and in vivo. RXFP1 is a G protein-coupled receptor with the extracellular low density lipoprotein A (LDL-A) module located at the N-terminus. The LDL-A module exhibits a competitive inhibition effect on the RXFP1 function and might be used to suppress relaxin signaling. In this study, we investigated the effect of LDL-A overexpression on prostate cancer cells. PC3 cells expressing the RXFP1-LDL-A module had a decreased proliferation, soft agar colony formation, adhesion, invasion in vitro, and grew at a slower rate than control cells as tumors in xenograft models in mice. Expression analysis revealed that the RXFP1-LDL-A expression in PC3 cells inhibited Akt phosphorylation and MMP2 activation, and led to the down-regulation of several genes previously implicated in tumorigenesis, such as MMP28, S100P, IGFBP2, MUC1 and S100A4. These results indicate that the inhibition of RXFP1 by peptide based on the LDL-A module of this receptor may be a potential approach for prostate cancer suppression.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Feng S,Agoulnik AIdoi
10.3892/ijo.2011.1159subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1559-65issue
6eissn
1019-6439issn
1791-2423journal_volume
39pub_type
杂志文章abstract::Previously we demonstrated that a mutated human prolactin (hPRL) with a single amino acid substitution at position 129 (hPRL-G129R) was able to inhibit human breast cancer cell proliferation via the induction of apoptosis. In this study, we report the in vivo anti-tumor effects of hPRL-G129R in nude mice bearing human...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.20.4.813
更新日期:2002-04-01 00:00:00
abstract::We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::The signal transducer and activator of transcription 3 (STAT3) factor plays an important role in the tumorigenicity of cancer stem cells. The purpose of this study was to investigate the inhibitory mechanism of this pathway acting through the tumor suppressor von Hippel-Lindau (VHL) protein in glioma cancer stem cells...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1773
更新日期:2013-03-01 00:00:00
abstract::Irvalec® (elisidepsin trifluoroacetate, PM02734) is a novel marine-derived cyclic peptide belonging to the Kahaladide family of compounds, currently in clinical trials with preliminary evidence of antitumor activity. Previous studies have shown a correlation between elisidepsin sens...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1425
更新日期:2012-07-01 00:00:00
abstract::Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2833
更新日期:2015-03-01 00:00:00
abstract::Inflammatory abnormalities have been implicated in the pathogenesis of various human diseases, including cancer. Interleukin-1 receptor antagonist (IL1RN) is a potent anti-inflammatory molecule that modulates the biological activity of the proinflammatory cytokine, interleukin-1. The aim of this study was to examine t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2917
更新日期:2015-05-01 00:00:00
abstract::Licochalcone A (LCA) is a natural product derived from the roots of Glycyrrhiza inflata exhibiting a wide range of bioactivities such as antitumor, anti-oxidant and anti-bacterial effects. Malignant pleural mesothelioma (MPM) is an extremely aggressive type of cancer with a poor prognosis because of its rapid progress...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2839
更新日期:2015-03-01 00:00:00
abstract::Recently, a novel candidate tumor suppressor gene, DPC 4/SMAD 4, has been implicated in the development of pancreatic cancers. Its location at human chromosome 18q21 prompted us to investigate this gene in a large series of primary tumors located outside the gastrointestinal tract which have been associated with loss ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::Dickkopf‑related protein 3 (DKK3), which is a member of the Dickkopf WNT signaling pathway inhibitor family, is considered to be a tumor suppressor, due to its reduced expression in cancer cells and its ability to induce apoptosis when overexpressed by adenovirus. However, our previous study demonstrated alternative f...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4667
更新日期:2019-03-01 00:00:00
abstract::Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.4.677
更新日期:1997-04-01 00:00:00
abstract::The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::It has previously been suggested that some tumours may elaborate substances which can suppress the functional activity of lymphokine activated killer (LAK) cells. We have investigated the effects of secreted products from the colorectal cancer cell line LoVo on the pattern of expression of T lymphocyte subsets and nat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.4.763
更新日期:1993-10-01 00:00:00
abstract::Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Hepatocellular carcinoma is one of the most common cancers in the world. Previously, we found that the level of glucocorticoid receptor was significantly higher in hepatocellular carcinoma than in adjacent liver tissues. Moreover, in vitro and in vivo studies showed that glucocorticoid stimulated the growth of hepatom...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer related deaths in men in the United States. Ciprofloxacin is a relatively non-toxic antibiotic that can be easily administered orally with large volume of distribution and good tissue penetration. Studies from others and our l...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.12.5.1199
更新日期:1998-05-01 00:00:00
abstract::Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4654
更新日期:2019-02-01 00:00:00
abstract::Understanding the link between chemoresistance and cancer progression may identify future targeted therapy for breast cancer. One of the mechanisms by which chemoresistance is attained in cancer cells is mediated through the expression of multidrug resistance proteins (MRPs). Acquiring drug resistance has been correla...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3534
更新日期:2016-08-01 00:00:00
abstract::Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying development of multidrug-resistance in NB we established two neuroblastoma cell sublines resistant to vincristine (UKF-NB-3rVCR10) and doxorubicin (UKF-NB-3rDOX20...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.7.6.1339
更新日期:1995-12-01 00:00:00
abstract::Thirty patients who underwent hepatectomy for the treatment of hepatocellular carcinoma (HCC) were examined for expression of HLA class I antigens on HCC cells by flow cytometry. The expression was found significantly lower in cases of stage IV compared with those of stage I or stage II (p<0.05), and in cases of intra...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.6.1243
更新日期:1996-06-01 00:00:00
abstract::Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000535
更新日期:2010-03-01 00:00:00
abstract::Cytogenetic analyses of peripheral blood cells of breast cancer patients unveiled in one case a grossly enlarged G-band in one copy of chromosome 16 (16qh+), which scored also strongly positive in C-banding. Fluorescence in situ hybridization with both a total chromosome 16 library and with probe pHuR195 detecting loc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.347
更新日期:1994-02-01 00:00:00
abstract::To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.481
更新日期:1994-02-01 00:00:00
abstract::Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
abstract::Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hal...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1450
更新日期:2012-07-01 00:00:00
abstract::Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1105
更新日期:2011-10-01 00:00:00
abstract::CD34 is commonly used as an endothelial cell marker of tumor vessels. However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed endothelial cells. In this study,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2980
更新日期:2015-07-01 00:00:00