DPC 4/SMAD 4 in non-pancreatic tumors with frequent LOH 18q21 and in hematological malignancies.

abstract：:Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 part...

journal_title：International journal of oncology

authors： Tomirotti M,Bernardo G,Epifani C,Biasioli R,Franchi R,Mensi F,Carnaghi P,Schieppati G,Scanni A

更新日期：1993-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...

journal_title：International journal of oncology

authors： Collet N,Théoleyre S,Rageul J,Mottier S,Jouan F,Rioux-Leclercq N,Fergelot P,Patard JJ,Masson D,Denis MG

更新日期：2011-03-01 00:00:00

abstract：:The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...

journal_title：International journal of oncology

authors： Ebert M,Yokoyama M,Kobrin M,Friess H,Buchler M,Korc M

更新日期：1994-12-01 00:00:00

abstract：:Retinoids, which include vitamin A (retinol) and its derivatives, have previously been investigated as potential chemopreventive and chemotherapeutic agents in bladder cancer. We examined mRNA expression of the retinoid receptors RARalpha, RARbeta2, RARgamma and RXRalpha, as well as two putative RARbeta2 target genes,...

journal_title：International journal of oncology

authors： Boorjian S,Scherr DS,Mongan NP,Zhuang Y,Nanus DM,Gudas LJ

更新日期：2005-04-01 00:00:00

abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

journal_title：International journal of oncology

authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

更新日期：2007-10-01 00:00:00

abstract：:The neuroepithelioma cell line CHP100 expresses low but detectable amounts of N-myc protein together with large amounts of c-myc protein. We have recently demonstrated that antisense inhibition of N-myc expression in CHP100 cells leads to decreased in vitro growth and alterations in cellular morphology without affecti...

journal_title：International journal of oncology

authors： Rosolen A,Frascella E,Toretsky J,Neckers L

更新日期：1995-01-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome. We have previously reported that inhibitors of histone deacetylas...

journal_title：International journal of oncology

authors： Torres J,Regan PL,Edo R,Leonhardt P,Jeng EI,Rappaport EF,Ikegaki N,Tang XX

更新日期：2010-10-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00

abstract：:The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent with high tumor-selective cytotoxicity. The congenital and acquired resistance of some cancer types including malignant melanoma and osteosarcoma impede the current TRAIL therapy of these cancers. Since fine...

journal_title：International journal of oncology

authors： Ohshima Y,Takata N,Suzuki-Karasaki M,Yoshida Y,Tokuhashi Y,Suzuki-Karasaki Y

更新日期：2017-10-01 00:00:00

abstract：:Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...

journal_title：International journal of oncology

authors： Gazitt Y,Lavia M,Erdos G

更新日期：1993-09-01 00:00:00

abstract：:Cancer stem cells (CSCs) in glioma are often responsible for relapse and resistance to therapy. The purpose of the present study was to confirm the self-renewal and migration inhibitory effects of tetrandrine (Tet), which is a compound extracted from the dried root of Stephania tetrandra S. Moore, toward glioma stem-l...

journal_title：International journal of oncology

authors： Zhang Y,Wen YL,Ma JW,Ye JC,Wang X,Huang JX,Meng CY,Xu XZ,Wang SX,Zhong XY

更新日期：2017-01-01 00:00:00

abstract：:Women from ethnic minority groups, including immigrants and refugees are reported to have low breast cancer (BC) screening rates. Active, culturally-sensitive outreach is vital for increasing participation of these women in BC screening programs. Women at high BC risk and who belong to an ethnic minority group are of ...

journal_title：International journal of oncology

authors： Belkić K,Cohen M,Wilczek B,Andersson S,Berman AH,Márquez M,Vukojević V,Mints M

更新日期：2015-09-01 00:00:00

abstract：:On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRR...

journal_title：International journal of oncology

authors： Fujitomo T,Daigo Y,Matsuda K,Ueda K,Nakamura Y

更新日期：2014-07-01 00:00:00

abstract：:Reduced expression of a cyclin-dependent kinase inhibitor, p27, has been reported to be associated with poor prognosis in several human cancers. The aim of this study was to investigate the potential role of p27 in ovarian cancer development and progression. Immunohistochemical expression of p27 was determined using 1...

journal_title：International journal of oncology

authors： Shigemasa K,Shiroyama Y,Sawasaki T,Fujii T,Nagai N,Parmley TH,O'Brien TJ,Ohama K

更新日期：2001-05-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:Postoperative adjuvant chemotherapy reportedly improves advanced colorectal cancer patients' survival, however, it is necessary to assess what regimens are useful. Doxifluridine (5'-DFUR) is an intermediate of capecitabine approved in Europe and USA to treat metastatic colorectal cancer. 5'-DFUR is metabolized to 5-fl...

journal_title：International journal of oncology

authors： Koda K,Miyazaki M,Sarashina H,Suwa T,Saito N,Suzuki M,Ogawa K,Watanabe S,Kodaira S,Nakazato H

更新日期：2003-07-01 00:00:00

abstract：:Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH) are Hedgehog family ligands, which play key roles in embryogenesis and carcinogenesis, especially in pancreatic cancer and gastric cancer. Drosophila Costal-2 (Cos2) is a Hedgehog signaling regulator, interacting with Smoothened (Smo), Cubitus inter...

journal_title：International journal of oncology

authors： Katoh Y,Katoh M

更新日期：2004-12-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 20...

journal_title：International journal of oncology

authors： Mattern J,Koomagi R,Volm M

更新日期：1995-05-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...

journal_title：International journal of oncology

authors： Zhang MH,Hu YD,Xu Y,Xiao Y,Luo Y,Song ZC,Zhou J

更新日期：2013-04-01 00:00:00

abstract：:Patients with pancreatic cancer frequently demonstrate symptoms such as weight-loss and muscle wasting and have clinical evidence of a systemic inflammatory response. Such effects may be mediated by pro-inflammatory cytokines derived from tumor cells. The production of interleukin-6 and -8 by pancreatic cancer cell li...

journal_title：International journal of oncology

authors： Wigmore SJ,Fearon KC,Sangster K,Maingay JP,Garden OJ,Ross JA

更新日期：2002-10-01 00:00:00

abstract：:Sialic acid-containing glycosphingolipids, gangliosides, are expressed at high levels in the nerve tissues and various tumor cells. Although a number of studies on the roles of gangliosides in the regulation of cell proliferation have been performed, the mechanisms for the regulation are not well understood. We establ...

journal_title：International journal of oncology

authors： Nishio M,Tajima O,Furukawa K,Urano T,Furukawa K

更新日期：2005-01-01 00:00:00

abstract：:Mutations in p53 are the most common genetic abnormality in cancers. Arsenic trioxide (ATO) is an effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia (APL) and is being tested in phase II studies in various types of cancers. We have shown that ATO is a potent inducer of apoptosis in mult...

journal_title：International journal of oncology

authors： Kircelli F,Akay C,Gazitt Y

更新日期：2007-04-01 00:00:00

abstract：:Shc protein is known to be related to cell proliferation and carcinogenesis. However, the involvement of Shc in hepatocellular carcinoma (HCC) remains unknown. In the present study, we report that p46 Shc is probably expressed in the nuclei of hepatocytes and/or cancer cells during the development of HCC in Long-Evans...

journal_title：International journal of oncology

authors： Yoshida S,Masaki T,Feng H,Yuji J,Miyauchi Y,Funaki T,Yoshiji H,Matsumoto K,Uchida N,Watanabe S,Kurokohchi K,Kuriyama S

更新日期：2004-10-01 00:00:00

abstract：:Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...

journal_title：International journal of oncology

authors： Lin C,Tsai SC,Tseng MT,Peng SF,Kuo SC,Lin MW,Hsu YM,Lee MR,Amagaya S,Huang WW,Wu TS,Yang JS

更新日期：2013-03-01 00:00:00

abstract：:Mutations of p53 tumor suppressor gene increase with tumor progression in colorectal cancers. In this study, we examined the expressions of p33ING1, p14ARF, MDM2 and p21WAF1 mRNA in 25 advanced colorectal cancers by quantitative RT-PCR method, and compared the expression levels of p33ING1, p14ARF, p21WAF1 and MDM2 in ...

journal_title：International journal of oncology

authors： Tachibana M,Kawamata H,Fujimori T,Omotehara F,Horiuchi H,Ohkura Y,Igarashi S,Kotake K,Kubota K

更新日期：2004-10-01 00:00:00

abstract：:Trophoblasts are derived from the normal placenta, and they infiltrate into the endometrium and the maternal blood vessels under strict control but, unlike malignant cells, never metastasize. To understand the proliferative characteristics of trophoblasts and its related disorders, we assessed telomerase activity in c...

journal_title：International journal of oncology

authors： Nishi H,Yahata N,Ohyashiki K,Isaka K,Shiraishi K,Ohyashiki JH,Toyama K,Takayama M

更新日期：1998-01-01 00:00:00

abstract：:Plakoglobin is a tumor suppressor gene in lung cancer; however, the mechanism by which it is downregulated in lung cancer is largely unknown. The aim of the present study was to investigate whether histone deacetylases (HDACs) regulate plakoglobin expression in lung cancer. The effects of overexpression or knockdown o...

journal_title：International journal of oncology

authors： Sang Y,Sun L,Wu Y,Yuan W,Liu Y,Li SW

更新日期：2019-03-01 00:00:00

abstract：:Human papillomavirus 16 (HPV-16) is strongly associated with the development of 50% of cervical cancers. The E6 and E7 proteins encoded by high-risk HPV types are associated with the immune evasion of cervical cancer cells, but the mechanism is poorly understood. The purpose of this study was to investigate whether ce...

journal_title：International journal of oncology

authors： Gao LJ,Gu PQ,Fan WM,Liu Z,Qiu F,Peng YZ,Guo XR

更新日期：2011-11-01 00:00:00

abstract：:Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...

journal_title：International journal of oncology

authors： Sartippour MR,Heber D,Zhang L,Beatty P,Elashoff D,Elashoff R,Go VL,Brooks MN

更新日期：2002-09-01 00:00:00