In vitro modulation of MCF-7 breast cancer cell growth by myoepithelial cells.

abstract：:Breast cancer cells can switch from estrogen receptor α (ER)- to human epidermal growth factor receptor (HER)-driven cell growth upon acquiring antiestrogen resistance. HER ligands are cleaved by metalloproteinases leading to release of active HER ligands, activation of HER receptors and consequently increased cell gr...

journal_title：International journal of oncology

authors： Kirkegaard T,Yde CW,Kveiborg M,Lykkesfeldt AE

更新日期：2014-07-01 00:00:00

abstract：:Most malignant tumors have a defect in the Rb pathway that allows them to proliferate autonomously, unrestricted by the availability of mitogens and growth factors. This defect preconditions tumor cells to be less sensitive to inhibitors of growth factor receptors and/or signal transduction pathways that arrest normal...

journal_title：International journal of oncology

authors： Du L,Smolewski P,Bedner E,Traganos F,Darzynkiewicz Z

更新日期：2001-10-01 00:00:00

abstract：:In this study we investigated the relationship between the development of either HSILs (high-grade squamous intraepithelial lesions) or invasive cancers of the uterine cervix and the p53 codon 72 polymorphisms consisting of arginine (Arg)- or proline (Pro)-encoded allele in Japanese populations. Furthermore, we determ...

journal_title：International journal of oncology

authors： Kawamata Y,Mitsuhashi A,Unno Y,Kado S,Shino Y,Uesugi K,Eguchi O,Ishii J,Seki K,Sekiya S,Shirasawa H

更新日期：2002-09-01 00:00:00

abstract：:Cervical lymph node metastasis is the most common recurrence pattern of head and neck squamous cell carcinoma (HNSCC), and it is usually treated with radiation therapy and/or neck dissection. There has long been a desire for markers useful in predicting radiosensitivity to enable assignment of patients with recurrent ...

journal_title：International journal of oncology

authors： Ito Y,Kamijo T,Yokose T,Kawashima M,Ogino T,Ikeda H,Hayashi R,Sasaki S,Ochiai A

更新日期：2001-12-01 00:00:00

abstract：:Oxygen tension measurements were made in three tumors: (i) the murine FSaII fibrosarcoma, (ii) the rat 9L gliosarcoma and (iii) the rat 13672 mammary adenocarcinoma using a pO2 histograph. Tumor oxygenation measurements were made while the animals breathed air or breathed carbogen (95% oxygen/5% carbon dioxide). Pento...

journal_title：International journal of oncology

authors： Teicher B,Sotomayor E,Robinson M,Dupuis N,Schwartz G,Frei E

更新日期：1993-01-01 00:00:00

abstract：:Dickkopf‑related protein 3 (DKK3), which is a member of the Dickkopf WNT signaling pathway inhibitor family, is considered to be a tumor suppressor, due to its reduced expression in cancer cells and its ability to induce apoptosis when overexpressed by adenovirus. However, our previous study demonstrated alternative f...

journal_title：International journal of oncology

authors： Katase N,Nishimatsu SI,Yamauchi A,Yamamura M,Fujita S

更新日期：2019-03-01 00:00:00

abstract：:Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...

journal_title：International journal of oncology

authors： Patel MR,Sadiq AA,Jay-Dixon J,Jirakulaporn T,Jacobson BA,Farassati F,Bitterman PB,Kratzke RA

更新日期：2012-02-01 00:00:00

abstract：:Aurora-A is involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and regards to an oncogene. Aurora-A is also known to bind to several other proteins affecting its up-regulation or down-regulation and localization. However, how these different binding signals work together to regulate Auro...

journal_title：International journal of oncology

authors： Lieu AS,Cheng TS,Chou CH,Wu CH,Hsu CY,Huang CY,Chang LK,Loh JK,Chang CS,Hsu CM,Howng SL,Hong YR

更新日期：2010-08-01 00:00:00

abstract：:Recent studies have demonstrated that natural antisense transcripts, which are complementary sequences to messenger RNA, have important cellular functions such as the stabilization and silencing of mRNA. However, the possible contribution of antisense transcripts in hepatocellular c...

journal_title：International journal of oncology

authors： Nagai K,Kohno K,Chiba M,Pak S,Murata S,Fukunaga K,Kobayashi A,Yasue H,Ohkohchi N

更新日期：2012-06-01 00:00:00

abstract：:Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...

journal_title：International journal of oncology

authors： Jatoi A,Foster NR,Egner JR,Burch PA,Stella PJ,Rubin J,Dakhil SR,Sargent DJ,Murphy BR,Alberts SR

更新日期：2010-03-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the most common cancers in the world. Previously, we found that the level of glucocorticoid receptor was significantly higher in hepatocellular carcinoma than in adjacent liver tissues. Moreover, in vitro and in vivo studies showed that glucocorticoid stimulated the growth of hepatom...

journal_title：International journal of oncology

authors： Uen YH,Ko PH,Yin PH,Liu TY,Chi CW,Lui WY

更新日期：2008-12-01 00:00:00

abstract：:Endoscopic examination with iodine staining has led to the easy detection of multiple superficial esophageal carcinoma (MSEC). The purpose of this study was to better understand the characteristics of MSEC. Of 49 patients with multiple esophageal carcinomas, 19 had superficial carcinoma. Multiple esophageal carcinomas...

journal_title：International journal of oncology

authors： Fujii T,Yamana H,Fujita H,Sueyoshi S,Nakashima A,Hayashi I,Nishi M,Kato S,Shirouzu K,Morimatsu M

更新日期：1998-02-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) are involved in cell growth, apoptosis and differentiation. This study aimed to investigate the effects of HDACI scriptaid on histone modification, demethylation, cell growth, cell cycle and apoptosis in the RKO colorectal cancer cell line and screening for scriptaid-induced gen...

journal_title：International journal of oncology

authors： Lee EJ,Lee BB,Kim SJ,Park YD,Park J,Kim DH

更新日期：2008-10-01 00:00:00

abstract：:Ophiopogonin B (OP-B), a saponin compound isolated from Radix Ophiopogon japonicus, was verified to inhibit cell proliferation in numerous non-small cell lung cancer (NSCLC) cells in our previous study. However, the precise mechanisms of action have remained unclear. In the present study, we mainly investigated the ef...

journal_title：International journal of oncology

authors： Chen M,Guo Y,Zhao R,Wang X,Jiang M,Fu H,Zhang X

更新日期：2016-07-01 00:00:00

abstract：:Neuroblastoma is the second most common extracranial malignant solid tumor that occurs in childhood, and metastasis is one of the major causes of death in neuroblastoma patients. The epithelial-mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. T...

journal_title：International journal of oncology

authors： Shao JB,Gao ZM,Huang WY,Lu ZB

更新日期：2017-05-01 00:00:00

abstract：:Lumican is a member of the small leucine-rich proteoglycan (SLRP) family and participates in the maintenance of tissue structures and tumor growth. Neuroendocrine cell tumors (NETs) including carcinoid tumors and NE cell carcinomas (NECs) possess numerous neuroendocrine (NE) granules, and differences between these tum...

journal_title：International journal of oncology

authors： Shinji S,Tajiri T,Ishiwata T,Seya T,Tanaka N,Naito Z

更新日期：2005-04-01 00:00:00

abstract：:Astrocytomas are intracranial malignancies for which invasive growth and high motility of tumour cells preclude total resection; the tumours usually recur in a more aggressive and, eventually, lethal form. Clinical outcome is highly variable and the accuracy of morphology-based prognostic statements is limited. In ord...

journal_title：International journal of oncology

authors： Beetz C,Bergner S,Brodoehl S,Brodhun M,Ewald C,Kalff R,Krüger J,Patt S,Kiehntopf M,Deufel T

更新日期：2006-11-01 00:00:00

abstract：:The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody ...

journal_title：International journal of oncology

authors： Ishikawa T,Furihata M,Ohtsuki Y,Ono H,Inoue A,Ogoshi S

更新日期：1997-11-01 00:00:00

abstract：:Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for di...

journal_title：International journal of oncology

authors： Iwamoto H,Kanda Y,Sejima T,Osaki M,Okada F,Takenaka A

更新日期：2014-01-01 00:00:00

abstract：:Mismatch repair (MMR) genes play a fundamental role in the correction of replication errors, leading to cancer development when mutated. In order to test the hypothesis that the MMR system was compromised in the initiation and progression of breast cancer, we used an in vitro-in vivo model for analyzing the mRNA level...

journal_title：International journal of oncology

authors： Balogh GA,Russo IH,Russo J

更新日期：2003-08-01 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer related deaths in men in the United States. Ciprofloxacin is a relatively non-toxic antibiotic that can be easily administered orally with large volume of distribution and good tissue penetration. Studies from others and our l...

journal_title：International journal of oncology

authors： El-Rayes BF,Grignon R,Aslam N,Aranha O,Sarkar FH

更新日期：2002-07-01 00:00:00

abstract：:Peripheral blood mononulear cells (PBMC) derived from 10 asymptomatic human T lymphotropic virus type I (HTLV-I) carriers were cultured for a short term (10-14 days) in the absence of exogenous antigens. In 5 carriers, when compared with 5 HTLV-I non-carriers an apparent increase in the proportion of CD8+ DR+ cells wa...

journal_title：International journal of oncology

authors： Yang H,Furukawa K,Shinzato O,Kamihira S,Moji K,Takemoto T,Shiku H

更新日期：1994-08-01 00:00:00

abstract：:The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...

journal_title：International journal of oncology

authors： Moriya S,Komatsu S,Yamasaki K,Kawai Y,Kokuba H,Hirota A,Che XF,Inazu M,Gotoh A,Hiramoto M,Miyazawa K

更新日期：2015-02-01 00:00:00

abstract：:Although radiation therapy is a powerful anticancer modality, radiation- induced stress response and gene expression with adaptive resistance may severely compromise the effectiveness of radiation. The function of rotundic acid (RA) on inducing apoptosis in the human breast cancer cell line MCF-7 has been investigated...

journal_title：International journal of oncology

authors： Wang ZF,Sun WY,Yu DH,Zhao Y,Xu HM,He YF,Li HJ

更新日期：2018-11-01 00:00:00

abstract：:A relevant animal model is critical for investigating the pathogenic mechanisms underlying hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC). Mice are not naturally infected by HBV, presumably due to the lack of HBV receptors on mouse hepatocytes. To bypass this entry step of HBV infection, we report gene...

journal_title：International journal of oncology

authors： Huang YH,Fang CC,Tsuneyama K,Chou HY,Pan WY,Shih YM,Wu PY,Chen Y,Leung PS,Gershwin ME,Tao MH

更新日期：2011-12-01 00:00:00

abstract：:Experimental studies have established that the sulfated glycosaminoglycans heparan sulfate and chondroitin sulfate act as co-receptors of cytokines and growth factors that drive the malignant cell phenotype and the remodelling of the surrounding tumor stroma. However, the clinical relevance of these studies remains il...

journal_title：International journal of oncology

authors： Svensson KJ,Christianson HC,Kucharzewska P,Fagerström V,Lundstedt L,Borgquist S,Jirström K,Belting M

更新日期：2011-12-01 00:00:00

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:BALB/c 3T3 cells transformed by 1,1,2,2-tetrachloroethane, the most toxic chloroethane, acquired a fully malignant phenotype. They were capable of growing in soft agar, were tumorigenic when injected in athymic mice and produced pulmonary nodules after i.v. injection. Untreated BALB/c 3T3 cells were weakly tumorigenic...

journal_title：International journal of oncology

authors： Colacci A,Albini A,Melchiori A,Nanni P,Nicoletti G,Noonan D,Parodi S,Grilli S

更新日期：1993-06-01 00:00:00

abstract：:A herbal preparation denoted PC SPES(R) is available in 'natural food' or 'health food' stores in the United States. This mixture (patent pending, US Serial number 08/697,920) consists of extracts from 8 different herbs, 7 originating from China and one from America, and is sold as a dietary supplement. Although sever...

journal_title：International journal of oncology

authors： Halicka H,Ardelt B,Juan G,Mittelman A,Chen S,Traganos F,Darzynkiewicz Z

更新日期：1997-09-01 00:00:00

abstract：:Globally, breast cancer in women is the leading cause of cancer death. This fact has generated an interest to obtain insight into breast tumorigenesis and also to develop drugs to control the disease. Ras is a proto-oncogene that is activated as a response to extracellular signals. As a member of the Ras GTPase superf...

journal_title：International journal of oncology

authors： Ponce-Cusi R,Calaf GM

更新日期：2016-02-01 00:00:00