The role of gC1qR in regulating survival of human papillomavirus 16 oncogene-transfected cervical cancer cells.

abstract：:Expression and functions of interleukin (IL)-8, a pro-inflammatory cytokine with angiogenesis action, was examined in 23 surgically resected hepatocellular carcinoma (HCC) specimens and 7 HCC cell lines. In all HCC tissues, IL-8 expression was confirmed with reverse-transcription polymerase chain reaction method and e...

journal_title：International journal of oncology

authors： Akiba J,Yano H,Ogasawara S,Higaki K,Kojiro M

更新日期：2001-02-01 00:00:00

abstract：:Overexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents. Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB). The human gene for cMOAT (

journal_title：International journal of oncology

authors： Minemura M,Tanimura H,Tabor E

更新日期：1999-09-01 00:00:00

abstract：:The microtubule associated tumor suppressor gene 1 (MTUS1) is a recently published tumor suppressor gene, which has also been shown to act as an early component in the growth inhibitory signaling cascade of the angiotensin II type 2 receptor (AT2R). In this study we report the generation of MTUS1 knock-out (KO) mice, ...

journal_title：International journal of oncology

authors： Zuern C,Krenacs L,Starke S,Heimrich J,Palmetshofer A,Holtmann B,Sendtner M,Fischer T,Galle J,Wanner C,Seibold S

更新日期：2012-04-01 00:00:00

abstract：:Cordycepin (3'-deoxyadenosine), a major bioactive compound of Cordyceps militaris, has many pharmacological actions, such as anti-inflammatory and anticancer activities. In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in L...

journal_title：International journal of oncology

authors： Jeong JW,Jin CY,Park C,Han MH,Kim GY,Moon SK,Kim CG,Jeong YK,Kim WJ,Lee JD,Choi YH

更新日期：2012-05-01 00:00:00

abstract：:Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 ...

journal_title：International journal of oncology

authors： Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht U

更新日期：2010-04-01 00:00:00

abstract：:Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...

journal_title：International journal of oncology

authors： Zhang MH,Hu YD,Xu Y,Xiao Y,Luo Y,Song ZC,Zhou J

更新日期：2013-04-01 00:00:00

abstract：:The intensity of post-treatment melanoma patient follow-up varies widely among physicians. We investigated whether physician age accounts for the observed variation in surveillance intensity among plastic surgeons. A custom-designed questionnaire was mailed to USA and non-USA surgeons, all of whom were members of the ...

journal_title：International journal of oncology

authors： Margenthaler JA,Virgo KS,Johnson DY,Sugarbaker EM,Handler BS,Johnson FE

更新日期：2001-07-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...

journal_title：International journal of oncology

authors： Tait L,Dawson P,Wolman S,Galea K,Miller F

更新日期：1996-08-01 00:00:00

abstract：:Telomeres, repeated DNA sequences (T2AG3)n that guard the ends of chromosomes, serve as a checkpoint for cell-cycle progression and regulate cell senescence and apoptosis. Loss of the telomeric repeats promotes genomic instability, which is the hallmark of most cancer cells. Whether this loss differs among tumor cells...

journal_title：International journal of oncology

authors： Multani AS,Ozen M,Sen S,Mandal AK,Price JE,Fan D,Radinsky R,Ali-Osman F,Von Eschenbach AC,Fidler IJ,Pathak S

更新日期：1999-09-01 00:00:00

abstract：:Patients with esophageal carcinoma (ESCA) have a poor prognosis and high mortality rate. Although standard therapies have had effect, there is an urgent requirement to develop novel options, as increasing drug tolerance has been identified in clinical practice. In the present study, differentially expressed genes (DEG...

journal_title：International journal of oncology

authors： Chen YT,Xie JY,Sun Q,Mo WJ

更新日期：2019-01-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...

journal_title：International journal of oncology

authors： Jiao F,Hu H,Yuan C,Jin Z,Guo Z,Wang L,Wang L

更新日期：2014-10-01 00:00:00

abstract：:Induction of differentiation in a variety of model systems is accompanied by cell cycle exit and inhibition of Cdk2 kinase activity. We asked whether inhibition of Cdk2 activity is sufficient to allow differentiation to occur in a non-small cell lung cancer cell line. Treatment of NCI-H358 with flavopiridol, an inhibi...

journal_title：International journal of oncology

authors： Lee HR,Chang TH,Tebalt MJ 3rd,Senderowicz AM,Szabo E

更新日期：1999-07-01 00:00:00

abstract：:IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-...

journal_title：International journal of oncology

authors： Deforzh E,Vargas TR,Kropp J,Vandamme M,Pinna G,Polesskaya A

更新日期：2016-12-01 00:00:00

abstract：:Specific chromosomal abnormalities, such as del(7q), t(12;14), 12 trisomy, or the rearrangement of 6p, are seen in approximately 30% of uterine leiomyomas despite their benign status. We investigated the association between the shrinkage of uterine leiomyomas treated with a GnRH agonist and the interstitial deletion o...

journal_title：International journal of oncology

authors： Takahashi K,Kawamura N,Tsujimura A,Ichimura T,Ito F,Ishiko O,Ogita S

更新日期：2001-06-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy-based gastric carcinoma (GC) treatments, hence, biologically based therapies are urgently needed. Gastrin (GAS), a key gastrointestinal (GI) hormone, was found to be involved in tumor formation, progression, and metastasis. In this ...

journal_title：International journal of oncology

authors： Zhuang K,Zhang L,Zhang X,Tang H,Zhang J,Yan Y,Han K,Guo H

更新日期：2017-06-01 00:00:00

abstract：:Pemetrexed (PEM) is a novel, multitargeted, antifolate, antineoplastic agent for the treatment of non-small cell lung cancer and malignant pleural mesothelioma. Additional effects of nitric oxide (NO) donors on the chemosensitivity of cancers have been reported. However, the effects of an NO donor on PEM-induced cytot...

journal_title：International journal of oncology

authors： Nagai H,Yasuda H,Hatachi Y,Xue D,Sasaki T,Yamaya M,Sakamori Y,Togashi Y,Masago K,Ito I,Kim YH,Mio T,Mishima M

更新日期：2012-07-01 00:00:00

abstract：:Although CD138 expression is a hallmark of plasma cells and myeloma cells, reduced CD138 expression is occasionally found. However, the mechanisms underlying CD138 downregulation in myeloma cells remain unclear. Previous reports suggest that the bone marrow microenvironment may contribute to CD138 downregulation. Amon...

journal_title：International journal of oncology

authors： Kawano Y,Kikukawa Y,Fujiwara S,Wada N,Okuno Y,Mitsuya H,Hata H

更新日期：2013-12-01 00:00:00

abstract：:Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of hypericin aggregates present in the delivery vehicle on the biodistribution of the compound, we compared the in vivo tissue accumulation after administering hypericin...

journal_title：International journal of oncology

authors： Van De Putte M,Roskams T,Bormans G,Verbruggen A,De Witte PA

更新日期：2006-03-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a key growth factor linked to promoting cancer progression and angiogenesis. The present study identifies repulsive guidance molecule b (RGMb), a bone morphogenetic protein (BMP) co-receptor, as a gene whose expression is regulated by HGF and explores the potential of RGMb to contribu...

journal_title：International journal of oncology

authors： Sanders AJ,Ye L,Li J,Mason MD,Jiang WG

更新日期：2014-09-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:Chemokine-mediated activation of G protein-coupled receptors CXCR1/2 promotes tumor growth, invasion, inflammation and metastasis. Repertaxin, a CXCR1/2 small-molecule inhibitor, has been shown to attenuate many of these tumor-associated processes. The present study aimed to investigate the effects of repertaxin alone...

journal_title：International journal of oncology

authors： Wang J,Hu W,Wang K,Yu J,Luo B,Luo G,Wang W,Wang H,Li J,Wen J

更新日期：2016-04-01 00:00:00

abstract：:RhKGF is developed for prevention and treatment of chemotherapy- and radiation-induced epithelial damage in cancer patients. Little information exists on growth modulation of malignant cells by KGF. We have tested the anchorage-independent clonal growth of 35 human tumor and 22 lymphoma and leukemia cell lines in semi...

journal_title：International journal of oncology

authors： Oelmann E,Haghgu S,Kulimova E,Mesters RM,Kienast J,Herbst H,Schmitmann C,Kolkmeyer A,Serve H,Berdel WE

更新日期：2004-10-01 00:00:00

abstract：:MicroRNA (miRNA)-126 (miR-126) was reported to be downregulated and to act as a tumor suppressor in cancers of the lung, cervix, bladder and prostate. However, the functions of miR-126 in gastric cancer appear to be diverse and are largely unknown. MiR-126 was reported to act as a tumor suppressor by targeting the Crk...

journal_title：International journal of oncology

authors： Liu LY,Wang W,Zhao LY,Guo B,Yang J,Zhao XG,Hou N,Ni L,Wang AY,Song TS,Huang C,Xu JR

更新日期：2014-09-01 00:00:00

abstract：:Two mouse HPV16-transformed cell lines, viz. MK16 cells, which induce metastasizing tumors, and TC-1 cells, which induce non-metastasizing tumors were transduced with the gene for mouse endostatin. Two clones constitutively expressing endostatin were isolated from each of them. They were denoted ME3 and ME9, and TE2 a...

journal_title：International journal of oncology

authors： Lakatosova-Andelova M,Duskova M,Lucansky V,Paral P,Vonka V

更新日期：2009-07-01 00:00:00

abstract：:Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. ...

journal_title：International journal of oncology

authors： Kubo T,Sugita T,Shimose S,Nitta Y,Ikuta Y,Murakami T

更新日期：2000-08-01 00:00:00

abstract：:Toxicity of polyphenols against rat 3Y1 fibroblasts and the cells transformed by human adenovirus (Ad12-3Y1), its EIA gene (EIA-3Y1), or simian virus 40 (SV-3Y1) was examined. Among the diphenol compounds examined, pyrocatechol (o-diphenol) and hydroquinone (p-diphenol) showed selective toxicity against Ad12-3Y1 and E...

journal_title：International journal of oncology

authors： Yamada K,Mitsui T,Okuda A,Kimura G,Sugano M

更新日期：1993-01-01 00:00:00

abstract：:The aim of this study was to assess pivotal factors determining the oxygenation status of malignant tumors, and, for comparison, of normal tissues. For this purpose, microvascular patterns, blood flow data, O2 consumption rates and O2 extractions were correlated to the median pO2 values of isografted rodent and xenogr...

journal_title：International journal of oncology

authors： Vaupel P,Thews O,Kelleher DK,Konerding MA

更新日期：2003-04-01 00:00:00

abstract：:The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers. However, the function and molecular mechanisms of CXCR7 in human colorectal cancer (CRC) are still undefined. In the present study, sixty-eight cases of CRC tissues and corresponding adjac...

journal_title：International journal of oncology

authors： Li XX,Zheng HT,Huang LY,Shi DB,Peng JJ,Liang L,Cai SJ

更新日期：2014-10-01 00:00:00