Abstract:
:MicroRNA (miRNA)-126 (miR-126) was reported to be downregulated and to act as a tumor suppressor in cancers of the lung, cervix, bladder and prostate. However, the functions of miR-126 in gastric cancer appear to be diverse and are largely unknown. MiR-126 was reported to act as a tumor suppressor by targeting the Crk gene, or as an oncogene by targeting the SOX2 gene in gastric cancer. We identified that the expression of miR-126 was decreased in gastric cancer cell lines and tissues. PLK2, a tumor suppressor gene, was directly regulated by miR-126 in SGC-7901 cells. Overexpression of miR-126 not only suppressed the growth and clone formation of SGC-7901 cells, but also induced apoptosis in vitro, whereas inhibition of miR-126 slightly promoted SGC-7901 cell proliferation. The cell cycle was not affected by miR-126. Moreover, miR-126 suppressed tumor growth in vivo in a xenograft model. PLK2, PI3KR2 and Crk were regulated by miR-126 in SGC-7901 cells. We infer that the functions of miR-126 in gastric cancer depend on synergistic targeting balance between oncogenes and anti-oncogenes. Our study indicates that miR-126 is a tumor suppressor, which in the future may become a therapeutic target for gastric cancer.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Liu LY,Wang W,Zhao LY,Guo B,Yang J,Zhao XG,Hou N,Ni L,Wang AY,Song TS,Huang C,Xu JRdoi
10.3892/ijo.2014.2516subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1257-65issue
3eissn
1019-6439issn
1791-2423journal_volume
45pub_type
杂志文章abstract::Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1133
更新日期:2011-11-01 00:00:00
abstract::Resveratrol and other polyphenols have anti-carcinogenic and anti-tumorigenic activities in various carcinomas. However, such studies are limited in endometrial cancer. We hypothesize that resveratrol suppresses cancer growth through modulation of cell cycle and cell growth regulatory genes. To test this hypothesis, w...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy-based gastric carcinoma (GC) treatments, hence, biologically based therapies are urgently needed. Gastrin (GAS), a key gastrointestinal (GI) hormone, was found to be involved in tumor formation, progression, and metastasis. In this ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.3983
更新日期:2017-06-01 00:00:00
abstract::It has been reported that XAF1 expression in gastric cancer is negatively correlated with p53. Our purpose was to clarify the regulatory mechanism of p53 on XAF1 expression. The effects of overexpressed wild-type and mutant p53 on XAF1 expression were evaluated. Binding capacity of core XAF1 promoter sequence to the r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000584
更新日期:2010-04-01 00:00:00
abstract::The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated tumor cells (DTCs) homing to the BM has yet to be defined. MicroRNAs (miRNA) play key roles in cellular...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1112
更新日期:2011-11-01 00:00:00
abstract::Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tum...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.3.585
更新日期:2001-09-01 00:00:00
abstract::Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 part...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.3.2.213
更新日期:1993-08-01 00:00:00
abstract::Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract::Integrin alpha 6 is believed to be involved in malignant biological development. High tumor/normal (T/N) ratio of integrin alpha 6 was observed in intestinal type tumors in gastric carcinoma. In an immunohistochemical study, an intense and continuous staining was seen at the basement layer in the intestinal type tumor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.5.959
更新日期:1997-11-01 00:00:00
abstract::Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2021.5169
更新日期:2021-01-11 00:00:00
abstract::Thyroid cancer is a common endocrine cancer, of which papillary thyroid cancer (PTC) is the most common type. Neuregulin 1 (NRG1), a glycoprotein mediating cell‑cell signaling, plays vital roles in cellular activities; however, its role in PTC progression remains poorly understood. In this study, we performed immunohi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4426
更新日期:2018-08-01 00:00:00
abstract::Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.4.669
更新日期:1993-04-01 00:00:00
abstract::We have established a new human alphafetoprotein (AFP)-producing gallbladder carcinoma (GBC) cell line, termed KMG-C, from a 67-year-old Japanese male. KMG-C and its reconstituted tumors in nude mice showed the morphological features of an adenocarcinoma. Functionally, KMG-C secreted AFP, carcinoembryonic antigen, and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.6.1179
更新日期:1996-06-01 00:00:00
abstract::We previously reported in a retrospective study that CEA-based RT-PCR was useful for predicting the prognosis of patients with node-negative colorectal cancer. RT-PCR is well established for laboratory use, but many issues remain to be resolved prior to its clinical application. In addition to the false positive rate ...
journal_title:International journal of oncology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-09-01 00:00:00
abstract::The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::Cutaneous melanoma is an aggressive cancer with a poor prognosis for patients with advanced disease. The identification of several key molecular pathways implicated in the pathogenesis of melanoma has led to the development of novel therapies for this devastating disease. In melanoma, both the Ras/Raf/MEK/ERK (MAPK) a...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2014.2481
更新日期:2014-08-01 00:00:00
abstract::According to the current concept of carcinogenesis, neoplastic transformation consists of multistep accumulations of adverse genetic and epigenetic events. Recent advances in molecular genetics have demonstrated aberrations of oncogenes and tumor-suppressor genes in a variety of human cancers. The loss of wild-type p5...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.6.1209
更新日期:1995-06-01 00:00:00
abstract::Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. However, the effects of SAL on metastatic capacity of HT1080 human fibrosarcoma cells have not been elucidated. We investigated the effect of SAL on migration an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3448
更新日期:2016-06-01 00:00:00
abstract::Gene amplification is frequently found in human glioblastoma but the mechanisms driving amplifications remain to be elucidated. Hypoxia as hallmark of glioblastoma is known to be involved in the induction of fragile sites that are central to gene amplification. We analyzed the potential of hypoxia (pO2 0%) and mini hy...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2568
更新日期:2014-10-01 00:00:00
abstract::Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2445
更新日期:2014-08-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000545
更新日期:2010-03-01 00:00:00
abstract::Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000720
更新日期:2010-09-01 00:00:00
abstract::We established new two protein-free culture subclones from murine well-characterized Ehrlich ascites carcinoma and P815 mastocytoma using intermittent protein-free culture performed previously for a protein-free subclone of fibrosarcoma (Gc-4 PF). The Ehrlich protein-free subclone (Ehrlich PF) grew much more slowly th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.1.4.481
更新日期:1992-09-01 00:00:00
abstract::Induction chemotherapy provides an excellent model for evaluation of potential predictive factors. We studied expression of SBR grade, estrogen (ER) and progesterone (PR) receptors, HER2, Ki67 and P53 on core biopsies before and after chemotherapy in a series of 115 patients, who received anthracycline-based induction...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4223
更新日期:2018-02-01 00:00:00
abstract::Many traditional healing plants successfully passed several hundred years of empirical testing against specific diseases and thereby demonstrating that they are well tolerated in humans. Although quite a few ethno-pharmacological plants are applied against a variety of conditions there are still numerous plants that h...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000239
更新日期:2009-04-01 00:00:00