Identification and characterization of TMEM24 family genes in silico.

abstract：:Signet ring cell gastric cancer (SRCGC) has very poor prognosis worldwide, and studying its molecular characteristics is urgent for improving the outcome. However, few well-characterized SRCGC cell lines are available for research. Therefore, we established a novel cell line GCSR1, from a Chinese male SRCGC patient. C...

journal_title：International journal of oncology

authors： Xu X,Qian LJ,Su XY,He KF,Jin KT,Gu LH,Feng JG,Li GL,Zhou Q,Xu ZZ,Wang HH,Zhang J,Cao J,Teng LS

更新日期：2015-01-01 00:00:00

abstract：:Lymph node metastasis of breast cancer is a clinical marker of poor prognosis. Yet, there exist no therapies targeting mechanisms of intravasation into lymphatics. Herein we report on an effect of the antidyslipidemic drug fenofibrate with vasoprotective activity, which attenuates breast cancer intravasation in vitro,...

journal_title：International journal of oncology

authors： Nguyen CH,Huttary N,Atanasov AG,Chatuphonprasert W,Brenner S,Fristiohady A,Hong J,Stadler S,Holzner S,Milovanovic D,Dirsch VM,Kopp B,Saiko P,Krenn L,Jäger W,Krupitza G

更新日期：2017-05-01 00:00:00

abstract：:Point mutations in the K-ras gene are observed at a high incidence in human pancreatic carcinomas. These alterations can be used as potential targets for specific ribozyme-mediated reversal of the malignant phenotype. We designed an anti-K-ras ribozyme against codon 12 of the mutant K-ras gene transcripts (GGT right c...

journal_title：International journal of oncology

authors： Kijima H,Yamazaki H,Nakamura M,Scanlon KJ,Osamura RY,Ueyama Y

更新日期：2004-03-01 00:00:00

abstract：:Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and p...

journal_title：International journal of oncology

authors： Haneji T,Hirashima K,Teramachi J,Morimoto H

更新日期：2013-06-01 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone (GH-RH) inhibit growth of various human cancers including osteosarcomas and Ewing's sarcomas, xenografted into nude mice or cultured in vitro. The antiproliferative effect of GH-RH antagonists could be mediated, in part, through the splice variants (SVs) of receptors for...

journal_title：International journal of oncology

authors： Halmos G,Schally AV,Bernardino AL,Varga JL

更新日期：2006-08-01 00:00:00

abstract：:We performed interventional treatments on 50 patients with hepatocellular carcinoma (HCC) and analyzed the relationship between these treatments and the exacerbation of liver function after treatment. The different treatments included transcatheter arterial embolization (TAE), percutaneous ethanol injection therapy (P...

journal_title：International journal of oncology

authors： Okano H,Shiraki K,Inoue H,Deguchi M,Sugimoto K,Sakai T,Ohmori S,Murata K,Nakano T,Yamakado K,Takeda K

更新日期：2001-12-01 00:00:00

abstract：:Clinicopathological assessment of the functional relationship between the HER2 oncogene and tumor-associated fatty acid synthase (FASN) is largely precluded because immunohistochemical and/or mRNA studies should be performed in biopsies from breast cancer patients. We here sought to determine whether serum FASN (sFASN...

journal_title：International journal of oncology

authors： Vazquez-Martin A,Fernandez-Real JM,Oliveras-Ferraros C,Navarrete JM,Martin-Castillo B,Del Barco S,Brunet J,Menendez JA

更新日期：2009-12-01 00:00:00

abstract：:Meningiomas are the most commonly occurring intracranial tumors and account for approximately 15-20% of central nervous system tumors. Patients whose tumors recur after surgery and radiation therapy have limited therapeutic options. It has also been reported recently that radiation triggers DNA repair, cell survival a...

journal_title：International journal of oncology

authors： Gupta R,Rao Gogineni V,Nalla AK,Chetty C,Klopfenstein JD,Tsung AJ,Mohanam S,Rao JS

更新日期：2011-04-01 00:00:00

abstract：:The support mechanisms that are involved in lymph-node metastasis of oral squamous cell carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. In this study, we examined...

journal_title：International journal of oncology

authors： Ishikawa T,Nakashiro K,Hara S,Klosek SK,Li C,Shintani S,Hamakawa H

更新日期：2006-01-01 00:00:00

abstract：:Cordycepin is the main functional component of Cordyceps militaris, which has been widely used in oriental traditional medicine. This compound has been shown to possess many pharmacological properties, such as enhancing the body's immune function, and anti-inflammatory, anti-aging and anticancer effects. In the presen...

journal_title：International journal of oncology

authors： Lee HH,Park C,Jeong JW,Kim MJ,Seo MJ,Kang BW,Park JU,Kim GY,Choi BT,Choi YH,Jeong YK

更新日期：2013-03-01 00:00:00

abstract：:The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...

journal_title：International journal of oncology

authors： Chow LS,Wang X,Kwong DL,Sham JS,Tsao SW,Nicholls JM

更新日期：2000-07-01 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...

journal_title：International journal of oncology

authors： Koizumi K,Alonso S,Miyaki Y,Okada S,Ogura H,Shiiya N,Konishi F,Taya T,Perucho M,Suzuki K

更新日期：2012-04-01 00:00:00

abstract：:A multi stage extraction procedure which gives the possibility to analyze both water soluble and lipid components stemming from the same specimen has been developed in our laboratory. Metabolites from brain cancer biopsies have been compared to metabolites in normal human brain, developing mouse brain and primary mous...

journal_title：International journal of oncology

authors： Sonnewald U,Westergaard N,Isern E,Muller T,Schousboe A,Petersen S,Unsgard G

更新日期：1993-04-01 00:00:00

abstract：:We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration o...

journal_title：International journal of oncology

authors： Yatsunami J,Aoki S,Fukuno Y,Kikuchi Y,Kawashima M,Hayashi SI

更新日期：2000-12-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically where one of the mechanisms responsible for the invasion into facial bones occurs via the activation of osteoclasts. Copper has been demonstrated to play a key role in skeletal remodeling. However, the role of copper in cancer-assoc...

journal_title：International journal of oncology

authors： Morisawa A,Okui T,Shimo T,Ibaragi S,Okusha Y,Ono M,Nguyen TTH,Hassan NMM,Sasaki A

更新日期：2018-03-01 00:00:00

abstract：:The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...

journal_title：International journal of oncology

authors： Lohmeyer M,Mason S,Gullick W

更新日期：1997-04-01 00:00:00

abstract：:Lymphoid hyperplasia of lacrimal gland may be difficult to be differentiated from lymphomas on the basis of morphology and immunohistochemistry. The results of this study indicate that polymerase chain reaction should be employed for confirming the diagnosis of lymphoma in cases with histological and immunophenotypica...

journal_title：International journal of oncology

authors： Leoncini L,Funto I,Lazzi S,Pacenti L,Polito E,Bartolomei A,Leccisotti A,Cintorino M,Tosi P

更新日期：1993-11-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha). High incidence of lymphoma development in this transgenic mouse model system was similar to lymphoma development in p53 knockout mice. In an effort to understand the molecular basis of lymphomagenesis...

journal_title：International journal of oncology

authors： Haidar MA,Manshouri T,Keating MJ,Kantarjian HM,Freireich EJ,Mehta K,Albitar M

更新日期：2000-03-01 00:00:00

abstract：:Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7 cDNA expressed in esophageal cancer. The FZD7...

journal_title：International journal of oncology

authors： Kirikoshi H,Sekihara H,Katoh M

更新日期：2001-07-01 00:00:00

abstract：:Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptio...

journal_title：International journal of oncology

authors： Alqahtani T,Kumarasamy VM,Huczyński A,Sun D

更新日期：2020-01-01 00:00:00

abstract：:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotensio...

journal_title：International journal of oncology

authors： Cheung NK,Kushner BH,Yeh SD,Larson SM

更新日期：1998-06-01 00:00:00

abstract：:Changes in the promoter methylation of hTERT, the gene that encodes telomerase, a ribonucleoprotein responsible for replacing telomeric repeats, have been demonstrated in differentiating cells where hTERT is inhibited, suggesting epigenetic regulation of hTERT. All-trans retinoic acid (ATRA) induces differentiation in...

journal_title：International journal of oncology

authors： Love WK,Berletch JB,Andrews LG,Tollefsbol TO

更新日期：2008-03-01 00:00:00

abstract：:This retrospective study looks at the differences between adolescents (15-19 years) and young adults (20-25 years), diagnosed with Hodgkin lymphoma and treated at the same adult institution. Outcome according to risk category was evaluated, and although there were no significant differences in the whole cohort, or low...

journal_title：International journal of oncology

authors： Herbertson RA,Evans LS,Hutchinson J,Horsman J,Hancock BW

更新日期：2008-07-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:Antisense oligonucleotides have been investigated as anticancer agents administered alone or in combination with conventional chemotherapeutics. In the present study, we demonstrated synergistic effects between anti-MDM2 antisense oligonucleotides and the clinically used anticancer agent irinotecan, using nude mouse m...

journal_title：International journal of oncology

authors： Wang H,Wang S,Nan L,Yu D,Agrawal S,Zhang R

更新日期：2002-04-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types. However, the clinical significance of TNFAIP3 expression and function in esophageal...

journal_title：International journal of oncology

authors： Hadisaputri YE,Miyazaki T,Yokobori T,Sohda M,Sakai M,Ozawa D,Hara K,Honjo H,Kumakura Y,Kuwano H

更新日期：2017-03-01 00:00:00

abstract：:Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...

journal_title：International journal of oncology

authors： Ahmad SS,Glatzle J,Bajaeifer K,Bühler S,Lehmann T,Königsrainer I,Vollmer JP,Sipos B,Ahmad SS,Northoff H,Königsrainer A,Zieker D

更新日期：2013-08-01 00:00:00

abstract：:Autologous bone marrow transplantation (ABMT) often produces durable remission in patients with intermediate-high grade non-Hodgkin's lymphoma (NHL). We present a retrospective review of 32 eligible newly diagnosed patients with NHL treated with conventional induction chemotherapy followed by ABMT consolidation therap...

journal_title：International journal of oncology

authors： Montuoro A,Lalle M,Ingletto D

更新日期：2000-10-01 00:00:00