Abstract:
:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotension and anaphylactoid reactions were self-limited and manageable. Three pts are long-term survivors between 79-130+ months after 3F8 treatment without additional systemic therapy and no delayed neurological complications. The potential benefits of 3F8 when added to chemoradio-therapy warrant further investigation.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Cheung NK,Kushner BH,Yeh SD,Larson SMdoi
10.3892/ijo.12.6.1299subject
Has Abstractpub_date
1998-06-01 00:00:00pages
1299-306issue
6eissn
1019-6439issn
1791-2423journal_volume
12pub_type
临床试验,杂志文章abstract::Cell lines established from the TH-MYCN transgenic murine model of neuroblastoma are a valuable preclinical, immunocompetent, syngeneic model of neuroblastoma, for which knowledge of their p53 pathway status is important. In this study, the Trp53 status and functional response to Nutlin-3 and ionising radiation (IR) w...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4261
更新日期:2018-03-01 00:00:00
abstract::The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.5.1109
更新日期:1997-11-01 00:00:00
abstract::The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 was clearly demonstrated in two independent PLAG1 transgenic mouse founders, in which PLAG1 expression could be targeted to different tissues usin...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract::We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.6.1151
更新日期:2000-12-01 00:00:00
abstract::Globally, breast cancer in women is the leading cause of cancer death. This fact has generated an interest to obtain insight into breast tumorigenesis and also to develop drugs to control the disease. Ras is a proto-oncogene that is activated as a response to extracellular signals. As a member of the Ras GTPase superf...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3298
更新日期:2016-02-01 00:00:00
abstract::Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2806
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abstract::Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.3.519
更新日期:2001-09-01 00:00:00
abstract::Polo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role in colorectal cancer (CRC) development remains unknown. The present study demonstrated that PLK4 protein expression was upregulated in CRC tissues compared with in normal tissues thr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4659
更新日期:2019-02-01 00:00:00
abstract::Overexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents. Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB). The human gene for cMOAT ( journal_title:International journal of oncology pub_type: 杂志文章 doi:10.3892/ijo.15.3.559 更新日期:1999-09-01 00:00:00
abstract::Acquired drug resistance to chemotherapy is a major problem in the treatment of cancer. After primary surgical intervention, followed by chemotherapy treatments, the majority of patients develop disease recurrence. This is due to tumor cell heterogeneity and genetic instability. In contrast to tumor cells, proliferati...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2005-08-01 00:00:00
abstract::Thermal ablation of solid tumors using conductive interstitial thermal therapy (CITT) produces coagulative necrosis in the center of ablation. Local changes in homeostasis for surviving tumor and systemic changes in circulation and distant organs must be understood and monitored in order to prevent tumor re-growth and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2185
更新日期:2014-02-01 00:00:00
abstract::This study suggests that speckle-type POZ protein (SPOP) may be a tumor suppressor gene and its prognostic value in human glioma. Real-time quantitative RT-PCR (qRT‑PCR), western blotting, and immunohistochemical staining were used to examine SPOP expression in glioma tissues and normal brain (NB) tissues. The relatio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2729
更新日期:2015-01-01 00:00:00
abstract::The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-randomized trial in h...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:10.3892/ijo.16.6.1227
更新日期:2000-06-01 00:00:00
abstract::The two-kringle domain of tissue-type plasminogen activator (TK1-2) has been identified as a novel angiogenesis inhibitor. In the previous study, purified Pichia-derived TK1-2 has been shown to suppress in vivo growth of human lung and colon cancer cells. Here, we demonstrate that E. coli-derived non-glycosylated TK1-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-02-01 00:00:00
abstract::Human mammary and thyroid tumors as well as peripheral blood cells of the same patients were examined for the amplification of oncogene fins and the expression of its product. Of the 7 mammary tumors analyzed, amplification of fms was observed in 6 (86%) mammary tumor DNAs, while no amplification was seen in 5 thyroid...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.4.769
更新日期:1994-10-01 00:00:00
abstract::Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not wel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2647
更新日期:2014-12-01 00:00:00
abstract::A camptothecin (CPT) formulation that can be easily administered, is less toxic, and has greater antitumor effect is needed. In this study, a water-soluble CPT derivative was obtained by direct coupling of CPT to poly(L-glutamic acid) (PG) through the C20(S)-hydroxyl group. CPT was released from the resulting conjugat...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.18.2.331
更新日期:2001-02-01 00:00:00
abstract::Regulation of cytoplasmic p21CIP/WAF1 (p21) is of great clinical significance in molecular oncology due to its identification as an antiapoptotic factor, a poor survival predictor as well as a drug-resistance inducer. A retrospective study of the immunohistochemical (IHC) profiles of 128 human primary breast cancers s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::Human malignant neuroblastoma is characterized by poor differentiation and uncontrolled proliferation of immature neuroblasts. Retinoids such as all-trans-retinoic acid (ATRA), 13-cis-retinoic acid (13-CRA), and N-(4-hydroxyphenyl) retinamide (4-HPR) at low doses are capable of inducing differentiation, while flavonoi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000201
更新日期:2009-03-01 00:00:00
abstract::Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1599
更新日期:2012-11-01 00:00:00
abstract::We have previously demonstrated the multipotent nature of human umbilical cord blood stem cells (hUCB). In this study, we have attempted to show the use of hUCB in glioma therapy. We used hUCB enriched in CD44 and CD133 cells for our studies and observed that glioma cells co-cultured with hUCB undergo apoptosis. To pr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000599
更新日期:2010-05-01 00:00:00
abstract::Gene amplification is frequently found in human glioblastoma but the mechanisms driving amplifications remain to be elucidated. Hypoxia as hallmark of glioblastoma is known to be involved in the induction of fragile sites that are central to gene amplification. We analyzed the potential of hypoxia (pO2 0%) and mini hy...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract::Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to hepatocellular carcinoma (HCC) is currently unknown. The aim of this study was t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3398
更新日期:2016-04-01 00:00:00
abstract::Fanconi anemia complementation group D2 (FANCD2) is involved in the key steps of the Fanconi anemia (FA) pathway, which plays a role in the repair of DNA crosslink damage. However, the role of FANCD2 during radiotherapy for head and neck squamous cell carcinoma (HNSCC) is unclear. In this study, the HNSCC cell line HS...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2017-03-07 00:00:00
abstract::Expression of E-cadherin in esophageal carcinoma was studied immunohistochemically in 65 patients using an anti-human E-cadherin monoclonal antibody (HECD-1). In normal esophageal epithelium, E-cadherin was strongly expressed on cell-cell boundaries. On the contrary, a reduced E-cadherin expression (Rd-type) was frequ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Natural antisense transcripts (NATs) constitute a class of non-coding RNAs that have emerged as important regulators of gene expression. However, involvement of NATs in colorectal cancer (CRC) development has not been reported to date. In the present study, the up- and down-regulation of NATs were investigated in huma...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
abstract::Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.7.6.1339
更新日期:1995-12-01 00:00:00
abstract::Following the publication of this article, the authors noted that there was an error in Fig. 4. The lines representing the two groups were indicated incorrectly in all graphs in Fig. 4. A corrected version of Fig. 4 is presented below. Furthermore, we regret any inconvenience this error may have caused. [the original ...
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abstract::Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer. Anti-cancer effects are due to the virus ability: i) to replicate in and kill tumor cells, leading finally to their selective elimination; and ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::Polypyrimidine tract-binding protein 1 (PTBP1), a heterogeneous nuclear ribonucleoprotein, is a multi-functional RNA-binding protein. PTBP1 participates in a number of biological processes, including maintaining cell structure and motility, immunity, protein metabolism and the cell cycle. The present study aimed to in...
journal_title:International journal of oncology
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更新日期:2018-05-01 00:00:00