Hormone-dependent human tumors express the fms gene-product.

abstract：:Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, the antitumor mechanism of metformin in several types of cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal ...

journal_title：International journal of oncology

authors： Miyoshi H,Kato K,Iwama H,Maeda E,Sakamoto T,Fujita K,Toyota Y,Tani J,Nomura T,Mimura S,Kobayashi M,Morishita A,Kobara H,Mori H,Yoneyama H,Deguchi A,Himoto T,Kurokohchi K,Okano K,Suzuki Y,Murao K,Masaki T

更新日期：2014-07-01 00:00:00

abstract：:Paeonol, a potent antioxidant isolated from cortex moutan, possesses athero‑protective activity, yet the detailed mechanisms are not fully investigated. This study was conducted to explore the role of paeonol and its underlying mechanisms in RAW264.7 macrophages and apolipoprotein E‑deficient (ApoE(‑/‑)) mice. Paeonol...

journal_title：International journal of oncology

authors： Li X,Zhou Y,Yu C,Yang H,Zhang C,Ye Y,Xiao S

更新日期：2015-02-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, dr...

journal_title：International journal of oncology

authors： Suzuki Y,Inoue T,Murai M,Suzuki-Karasaki M,Ochiai T,Ra C

更新日期：2012-08-01 00:00:00

abstract：:The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...

journal_title：International journal of oncology

authors： Goh HS,Elnatan J,Low CH,Smith DR

更新日期：1999-09-01 00:00:00

abstract：:Interleukin-2 (IL-2) which has no cross-resistance with chemotherapy, has given responses in tumors resistant to chemotherapy, and shown to be more effective when tumor burden is low. 13-cis retinoic acid (RA) has immunomodulatory properties, potentially synergistic with IL-2. The objective of this pilot phase II stud...

journal_title：International journal of oncology

authors： Recchia F,De Filippis S,Rosselli M,Saggio G,Fumagalli L,Rea S

更新日期：2002-06-01 00:00:00

abstract：:Carnosic acid is a phenolic diterpene with anti-inflammation, anticancer, anti-bacterial, anti-diabetic, as well as neuroprotective properties, which is generated by many species from Lamiaceae family. Fisetin (3,3',4',7-tetrahydroxyflavone), a naturally flavonoid is abundantly produced in different vegetables and fru...

journal_title：International journal of oncology

authors： Shi B,Wang LF,Meng WS,Chen L,Meng ZL

更新日期：2017-06-01 00:00:00

abstract：:The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...

journal_title：International journal of oncology

authors： Fabricius EM,Kruse-Boitschenko U,Schneeweiss U,Wildner GP,Hoffmeister B,Raguse JD

更新日期：2011-11-01 00:00:00

abstract：:Evidence from the literature widely supports the efficacy of screening for colorectal cancer (CRC) in reducing mortality. A blood-based assay, potentially, represents a more accessible early detection tool for the identification of circulating tumour cells originating from a primary tumour site in the body. The presen...

journal_title：International journal of oncology

authors： Lauriola M,Ugolini G,Rosati G,Zanotti S,Montroni I,Manaresi A,Zattoni D,Rivetti S,Mattei G,Coppola D,Strippoli P,Taffurelli M,Solmi R

更新日期：2010-08-01 00:00:00

abstract：:In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cel...

journal_title：International journal of oncology

authors： Yanase S,Nomura J,Matsumura Y,Nagai K,Kinoshita M,Nakanishi H,Ohnishi Y,Tokuda T,Tagawa T

更新日期：2005-07-01 00:00:00

abstract：:The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes. Pituitary adenomas are a group of tumors arising from the pituitary gland: they may be subdivided in...

journal_title：International journal of oncology

authors： Spoletini M,Taurone S,Tombolini M,Minni A,Altissimi G,Wierzbicki V,Giangaspero F,Parnigotto PP,Artico M,Bardella L,Agostinelli E,Pastore FS

更新日期：2017-10-01 00:00:00

abstract：:An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

journal_title：International journal of oncology

authors： Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

更新日期：2011-07-01 00:00:00

abstract：:Selectivity of the anticancer agent PB-100 for malignant cells, already demonstrated using cell growth and viability evaluation, is now confirmed by microscopic observations. PB-100 is easily detected inside cells by its yellow color under visible light and by its blue fluorescence; it may be measured in isolated nucl...

journal_title：International journal of oncology

authors： Beljanski M,Crochet S

更新日期：1995-07-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a key growth factor linked to promoting cancer progression and angiogenesis. The present study identifies repulsive guidance molecule b (RGMb), a bone morphogenetic protein (BMP) co-receptor, as a gene whose expression is regulated by HGF and explores the potential of RGMb to contribu...

journal_title：International journal of oncology

authors： Sanders AJ,Ye L,Li J,Mason MD,Jiang WG

更新日期：2014-09-01 00:00:00

abstract：:The aim of the present study was to assess whether (-)-epigallocatechin 3-gallate (EGCG) via epigenetic modifications, regulates Raf kinase inhibitor protein (RKIP) expression and invasive metastatic activity in AsPC-1 pancreatic adenocarcinoma cells. Basal levels of RKIP were examined in various human pancreatic canc...

journal_title：International journal of oncology

authors： Kim SO,Kim MR

更新日期：2013-01-01 00:00:00

abstract：:Fatigue is one of the most common complaints of people with cancer. It affects the majority of patients actively undergoing cancer related therapies, but also a meaningful number of those who successfully completed therapy and are disease-free and potentially cured at the end of the treatments. In cancer setting, fati...

journal_title：International journal of oncology

authors： Tavio M,Milan I,Tirelli U

更新日期：2002-11-01 00:00:00

abstract：:The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy woul...

journal_title：International journal of oncology

authors： Pang Y,Liu J,Li X,Zhang Y,Zhang B,Zhang J,Du N,Xu C,Liang R,Ren H,Tang SC,Sun X

更新日期：2017-10-01 00:00:00

abstract：:Over-expression of p21Waf-1 was performed in 5 human glioma cell lines (U251MG, U87MG, T98G, NMC-G1, and KALS-1). p53 gene status was examined by PCR-SSCP and direct sequence method. The endogenous p21Waf-1 expression was evaluated by RT-PCR. Adenovirus-mediated over-expression of p21Waf-1 inhibited the proliferation ...

journal_title：International journal of oncology

authors： Terasaki M,Kato S,Sugita Y,Shigemori M,Morimatsu M

更新日期：1999-01-01 00:00:00

abstract：:Specific RE protein species modulated by autocrine TGF alpha are unknown. HCT116 cells transfected with TGF alpha antisense expression vector were compared with control HCT116 NEO for mitogenesis and modulation of high MW (130, 120 kD) and low MW (116, 110, 105 kD) RE species. Nutrients alone (N) induced maximal mitog...

journal_title：International journal of oncology

authors： Dobre C,Ziober B,Humphrey L,Brattain M

更新日期：1996-06-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade is a critical component in the regulation of cell survival and proliferation decisions. In breast carcinoma cells, activation of the p38-MAPK member of this family occurs in response to pro-inflammatory cytokines and cellular stress. The involvement of p38-MAPK in th...

journal_title：International journal of oncology

authors： Weldon CB,Parker AP,Patten D,Elliott S,Tang Y,Frigo DE,Dugan CM,Coakley EL,Butler NN,Clayton JL,Alam J,Curiel TJ,Beckman BS,Jaffe BM,Burow ME

更新日期：2004-06-01 00:00:00

abstract：:RhKGF is developed for prevention and treatment of chemotherapy- and radiation-induced epithelial damage in cancer patients. Little information exists on growth modulation of malignant cells by KGF. We have tested the anchorage-independent clonal growth of 35 human tumor and 22 lymphoma and leukemia cell lines in semi...

journal_title：International journal of oncology

authors： Oelmann E,Haghgu S,Kulimova E,Mesters RM,Kienast J,Herbst H,Schmitmann C,Kolkmeyer A,Serve H,Berdel WE

更新日期：2004-10-01 00:00:00

abstract：:SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta‑analysis based on multiple...

journal_title：International journal of oncology

authors： Liu AG,Zhong JC,Chen G,He RQ,He YQ,Ma J,Yang LH,Wu XJ,Huang JT,Li JJ,Mo WJ,Qin XG

更新日期：2020-07-01 00:00:00

abstract：:Fcγ receptors (FcγRs) on effector cells are of importance for mediating antibody-dependent cellular cytotoxicity (ADCC). FcγRIIIa158valine (V)/phenylalanine (F) and FcγRIIa131histidine (H)/arginine(R) polymorphisms have been shown to relate to prognosis in antibody-treated patients. The aim of the present study was to...

journal_title：International journal of oncology

authors： Wang B,Kokhaei P,Mellstedt H,Liljefors M

更新日期：2010-12-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:Early-onset breast cancer is one of the most common malignancies and causes of death among young women, and its incidence is increasing. In the present study, we aimed to investigate the epigenetic modifications of the breast cancer type 1 susceptibility gene (BRCA1) in breast tissues and blood cells derived from wome...

journal_title：International journal of oncology

authors： Al-Moghrabi N,Al-Qasem AJ,Aboussekhra A

更新日期：2011-07-01 00:00:00

abstract：:TGF-β-induced epithelial-mesenchymal transition (EMT) plays an important role in tumor progression. We assessed whether the TGF-β-induced EMT contributed to vasculogenic mimicry (VM) formation in glioma, we established an SHG44 cell line stably transfected with TGF-β cDNA loaded lentivirus. SB203580 was employed to in...

journal_title：International journal of oncology

authors： Ling G,Ji Q,Ye W,Ma D,Wang Y

更新日期：2016-12-01 00:00:00

abstract：:Protein disulfide‑isomerase A3 (PDIA3) is a chaperone protein that modulates folding of newly synthesized glycoproteins and responds to endoplasmic reticulum (ER) stress. Previous studies reported that increased expression of PDIA3 in hepatocellular carcinoma (HCC) is a marker for poor prognosis. However, the mechanis...

journal_title：International journal of oncology

authors： Kondo R,Ishino K,Wada R,Takata H,Peng WX,Kudo M,Kure S,Kaneya Y,Taniai N,Yoshida H,Naito Z

更新日期：2019-04-01 00:00:00

abstract：:Five retinoblastoma tumours from patients treated in the King Khaled Eye Specialist Hospital in Riyadh were analysed for mutations in the RB1 gene using single strand conformation polymorphism analysis and mutations were found in all of them. In one tumour the mutation in exon 11 was homozygous demonstrating the role ...

journal_title：International journal of oncology

authors： Su G,Senft S,Cowell J

更新日期：1995-03-01 00:00:00

abstract：:Mismatch repair (MMR) genes play a fundamental role in the correction of replication errors, leading to cancer development when mutated. In order to test the hypothesis that the MMR system was compromised in the initiation and progression of breast cancer, we used an in vitro-in vivo model for analyzing the mRNA level...

journal_title：International journal of oncology

authors： Balogh GA,Russo IH,Russo J

更新日期：2003-08-01 00:00:00

abstract：:A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the eff...

journal_title：International journal of oncology

authors： Chiao JW,Xu W,Yang YM,Kancherla R,Seiter K,Ahmed T,Mittelman A

更新日期：1999-10-01 00:00:00

abstract：:Clinical trials using antiangiogenic drugs revealed their potential against cancer. Unfortunately, a large percentage of patients does not yet benefit from this therapeutic approach highlighting the need of diagnostic tools to non-invasively evaluate and monitor response to therapy. It would also allow to predict whic...

journal_title：International journal of oncology

authors： Taurone S,Galli F,Signore A,Agostinelli E,Dierckx RA,Minni A,Pucci M,Artico M

更新日期：2016-08-01 00:00:00